Multifunctional recombinant phycobiliprotein-based fluorescent constructs and phycobilisome display
Patent
·
OSTI ID:1174586
The invention provides multifunctional fusion constructs which are rapidly incorporated into a macromolecular structure such as a phycobilisome such that the fusion proteins are separated from one another and unable to self-associate. The invention provides methods and compositions for displaying a functional polypeptide domain on an oligomeric phycobiliprotein, including fusion proteins comprising a functional displayed domain and a functional phycobiliprotein domain incorporated in a functional oligomeric phycobiliprotein. The fusion proteins provide novel specific labeling reagents.
- Research Organization:
- Univ. of California, Oakland, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG-91ER61125
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Number(s):
- 6,649,376
- Application Number:
- 09/469,194
- OSTI ID:
- 1174586
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:1174586