skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Method and apparatus for fluid dispersion

Patent ·
OSTI ID:1174207

A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.

Research Organization:
Harvard Univ., Cambridge, MA (United States); University of Toronto, Toronto, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-00ER45852
Assignee:
President and Fellows of Harvard College (Cambridge, MA); The Governing Council of the Univ. of Toronto (Toronto, CA)
Patent Number(s):
8,986,628
Application Number:
13/679,190
OSTI ID:
1174207
Resource Relation:
Patent File Date: 2012 Nov 16
Country of Publication:
United States
Language:
English

References (175)

Continuous manufacturing method for microspheres and apparatus patent January 2001
Method and apparatus for fluid dispersion patent December 2012
Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting journal January 2004
Microfabricated elastomeric valve and pump systems patent June 2002
Emulsions: basic principles journal January 1999
One-Dimensional Simulation of the Breakup of Capillary jets of Conducting Liquids. Application to E.H.D. Spraying journal August 1999
Quantitative DNA fiber mapping patent December 1998
Microfabricated crossflow devices and methods patent November 2007
Miniaturising the laboratory in emulsion droplets journal September 2006
Stabilization of liquid nutritional products and method of making patent October 1997
Micro-flow system for particle separation and analysis patent August 2002
Micro/Nano Encapsulation via Electrified Coaxial Liquid Jets journal March 2002
Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device journal April 2001
Effective Formation of Silicone-in-Fluorocarbon-in-Water Double Emulsions: Studies on Droplet Morphology and Stability journal September 2002
Controlled protein delivery from biodegradable tyrosine-containing poly(anhydride-co-imide) microspheres journal July 1997
Device for mixing two fluids having different temperatures patent September 1995
Multiple emulsions comprising a hydrophobic continuous phase patent November 1999
Interfacial Tension Driven Monodispersed Droplet Formation from Microfabricated Channel Array journal September 2001
Apparatus and method for forming films patent August 1999
Microfabricated crossflow devices and methods patent-application May 2002
Solid immersion lens structures and methods for producing solid immersion lens structures patent October 2001
Perfectly Monodisperse Microbubbling by Capillary Flow Focusing journal December 2001
Microfabricated cell sorter for chemical and biological materials patent April 2003
Stabilized capillary microjet and devices and methods for producing same patent September 2000
Method and statistical micromixer for mixing at least two liquids patent August 2005
High throughput screening assay systems in microscale fluidic devices patent October 2003
Man-made cell-like compartments for molecular evolution journal July 1998
Dewetting Instability during the Formation of Polymersomes from Block-Copolymer-Stabilized Double Emulsions journal May 2006
High throughput screening assay systems in microscale fluidic devices patent July 2001
Process for manipulating microscopic, dielectric particles and a device therefor patent November 2000
Generation of Polymerosomes from Double-Emulsions journal September 2005
Cross-linked water-swellable polymer particles patent November 1977
Electrocoalesce-separators for the separation of aqueous drops from a flowing dielectric viscous liquid journal October 2002
Focusing of microparticles in microfluidic systems patent January 2003
Methods and apparatus for dispersing a fluent material utilizing an electron beam patent January 1995
High throughput screening assay systems in microscale fluidic devices patent August 1999
Solid immersion lens structures and methods for producing solid immersion lens structures patent May 2003
Encapsulation of Bovine Serum Albumin in Temperature-Programmed“Shell-in-Shell” Structures journal November 2003
Fuel injection nozzle and method of use patent February 2001
Microfluidic Control Using Colloidal Devices journal June 2002
Stabilized capillary microjet and devices and methods for producing same patent June 2002
Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter journal January 2003
Transdermal delivery of glucose through hairless rat skin in vitro: effect of multiple and simple emulsions journal September 1998
Dispensing device and method for forming material patent June 2001
Method and apparatus for fluid dispersion patent May 2010
Electrospray ion source for mass spectroscopy patent April 2007
Coaxial jets generated from electrified Taylor cones. Scaling laws journal May 2003
Capillary transport device having speed and meniscus control means patent October 1986
Controlled fission of droplet emulsion in bifurcating microfluidic channels
  • IEEE International Solid-State Sensors and Actuators Conference, TRANSDUCERS '03. 12th International Conference on Solid-State Sensors, Actuators and Microsystems. Digest of Technical Papers (Cat. No.03TH8664) https://doi.org/10.1109/SENSOR.2003.1215245
conference January 2003
Controlled formulation of monodisperse double emulsions in a multiple-phase microfluidic system journal January 2005
Method and apparatus for dispersing a gas into a liquid patent June 1990
Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream patent September 2004
Capturing a Photoexcited Molecular Structure Through Time-Domain X-ray Absorption Fine Structure journal April 2001
Capillary array and related methods patent August 2003
Device and method for creating spherical particles of uniform size patent March 2001
Liquid atomization process patent September 2000
Electrostatic spray module patent May 2001
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays journal April 1999
High-throughput screening assay systems in microscale fluidic devices patent August 2002
Secretions of proteins by encapsulated cells patent October 2004
On the stability of ascorbic acid in emulsified systems for topical and cosmetic use journal October 1999
Optical sorting method patent-application August 2002
Solid immersion lens structures and methods for producing solid immersion lens structures patent August 2003
Monodisperse Emulsion Generation via Drop Break Off in a Coflowing Stream journal January 2000
Apparatus for particles patent January 1989
Production of lipospheres as carriers for bioactive compounds journal June 2002
Fluid separation device patent March 2011
Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles journal November 2002
In Vitro Evolution In Microfluidic Systems patent-application April 2006
Apparatus for producing a spray of droplets of a liquid patent May 1989
Electrostatic and hydrodynamic separation of aqueous drops in a flowing viscous oil journal September 2002
Induction of asymmetry in vesicles patent April 1993
In vitro evolution in microfluidic systems patent June 2011
Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network patent-application September 2005
Control of concentration and volume gradients in microfluidic droplet arrays for protein crystallization screening conference January 2004
An Axisymmetric Flow-Focusing Microfluidic Device journal April 2005
Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber patent March 2001
Liquid atomization procedure patent June 2001
Process for producing emulsion and microcapsules and apparatus therefor patent September 2007
Method and device for production of components for microfabrication patent September 2002
Electronic control of fluidic species patent July 2014
A Microfluidic Approach for Screening Submicroliter Volumes against Multiple Reagents by Using Preformed Arrays of Nanoliter Plugs in a Three-Phase Liquid/Liquid/Gas Flow journal April 2005
Stabilized capillary microjet and devices and methods for producing same patent May 2001
Optimization of Shear Driven Droplet Generation in a Microfluidic Device conference January 2003
Electric Control of Droplets in Microfluidic Devices journal April 2006
Hydrodynamic focusing devices patent October 2006
Formation of microstamped patterns on surfaces and derivative articles patent April 1996
Directed evolution of polymerase function by compartmentalized self-replication journal March 2001
Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber patent May 2002
Microfluidic systems including three-dimensionally arrayed channel networks patent November 2003
PLGA microspheres containing plasmid DNA: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization journal January 1999
Single channel continuous flow system patent August 1989
Method for electrically producing dispersions of a nonconductive fluid in a conductive medium patent June 1998
Apparatus and method for determining luminosity of hydrocarbon fuels patent September 1989
Method and Apparatus for Forming Multiple Emulsions patent-application May 2009
High throughput screening assay systems in microscale fluidic devices patent April 2000
Generation of monodisperse gel emulsions in a microfluidic device journal January 2006
W/O/W multiple emulsions of insulin containing a protease inhibitor and an absorption enhancer: biological activity after oral administration to normal and diabetic rats journal June 1998
Enhanced food products patent June 2001
Generation of Steady Liquid Microthreads and Micron-Sized Monodisperse Sprays in Gas Streams journal January 1998
Multiplex analysis of DNA patent September 1992
Microfluidic devices and methods of use thereof patent-application January 2008
Method and device for production of components for microfabrication patent February 2001
Device and method for creating dry particles patent January 2001
Process and apparatus for the production of nanofibers patent February 2003
A microfabricated fluorescence-activated cell sorter journal November 1999
Method of forming articles including waveguides via capillary micromolding and microtransfer molding patent March 2002
Chemical amplification based on fluid partitioning in an immiscible liquid patent September 2010
Capacitance cytometry: Measuring biological cells one by one journal September 2000
Low emulsifier multiple emulsions patent December 2003
Controllable delivery of non-viral DNA from porous scaffolds journal January 2003
Seamless capsule and method of manufacturing the same patent March 1999
Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber patent May 2003
Fuel injection nozzle and method of use patent April 2003
Fuel injection nozzle and method of use patent May 2002
Compartmentalised screening by microfluidic control patent-application April 2007
Controlled Production of Monodisperse Double Emulsions by Two-Step Droplet Breakup in Microfluidic Devices journal November 2004
High speed particle sorter using a field emission electrode patent July 1981
Device and method for creating spherical particles of uniform size patent October 2002
Moving microdroplets patent October 2000
Combinatorial synthesis system patent January 2003
Drug-releasing scaffolds fabricated from drug-loaded microspheres journal November 2001
Microfluidic sorting device patent June 2006
Microfluidic switch for embryo and cell sorting
  • Chen, C. C.; Zappe, S.; Sahin, O.
  • IEEE International Solid-State Sensors and Actuators Conference, TRANSDUCERS '03. 12th International Conference on Solid-State Sensors, Actuators and Microsystems. Digest of Technical Papers (Cat. No.03TH8664) https://doi.org/10.1109/sensor.2003.1215559
conference January 2003
Apparatus for forming liquid droplets having a mechanically fixed inner microtube patent February 1999
Preparation of a stable double emulsion (W1/O/W2): role of the interfacial films on the stability of the system journal December 2002
Method and apparatus for analysis and sorting of polynucleotides based on size patent April 2001
Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber patent October 2001
A Microfluidic System for Controlling Reaction Networks in Time journal February 2003
Preparation of Silica Particles Encapsulating Retinol Using O/W/O Multiple Emulsions journal August 2001
Degradation of porous poly(anhydride-co-imide) microspheres and implications for controlled macromolecule delivery journal January 1998
Formation of dispersions using “flow focusing” in microchannels journal January 2003
Motion, deformation and break-up of aqueous drops in oils under high electric field strengths journal April 2003
Man-made enzymes — from design to in vitro compartmentalisation journal August 2000
Generation of Monodisperse Particles by Using Microfluidics: Control over Size, Shape, and Composition journal January 2005
Application of advanced cytometric and molecular technologies to minimal residual disease monitoring conference April 2000
Method for spray combination of liquids and apparatus therefor patent April 1985
Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same patent September 2000
High throughput screening assay systems in microscale fluidic devices patent May 2003
Research News journal December 2002
Microfluidic devices for controlled viscous shearing and formation of amphiphilic vesicles patent-application February 2005
Narrow spray angle liquid fuel atomizers for combustion patent April 1997
Dielectrophoretic manipulation of drops for high-speed microfluidic sorting devices journal January 2006
The behaviour of a liquid–liquid interface and drop-interface coalescence under the influence of an electric field journal March 2003
Comparative study on sustained release of human growth hormone from semi-crystalline poly(l-lactic acid) and amorphous poly(d,l-lactic-co-glycolic acid) microspheres: morphological effect on protein release journal July 2004
High throughput screening assay systems in microscale fluidic devices patent October 2001
Insulin-loaded biodegradable PLGA microcapsules: initial burst release controlled by hydrophilic additives journal June 2002
Optimization of Droplet Generation by Controlling PDMS Surface Hydrophobicity conference January 2004
Microfluidic flow transducer based on the measurement of electrical admittance journal January 2004
Apparatus for manipulating droplets patent October 2012
Emulsions and Techniques for Formation patent-application January 2009
Electrostatic enhancement of coalescence of water droplets in oil: a review of the technology journal January 2002
Fuel injection nozzle and method of use patent August 2002
Single-molecule PCR using water-in-oil emulsion journal April 2003
pH-sensitive microsphere delivery increases oral bioavailability of calcitonin journal July 2004
Preparation of pharmaceutical or cosmetic dispersions patent February 1991
High throughput screening assay systems in microscale fluidic devices patent May 2003
Eye surgical instrument patent September 1976
Double emulsions stabilized by new molecular recognition hybrids of natural polymers journal October 2002
High throughput screening assay systems in microscale fluidic devices patent June 2002
Flow cytometry for high throughput screening patent May 2005
In vitro sorting method patent December 2002
Microlensing particles and applications patent September 2003
Microfluidic chromatography patent June 2004
Emulsion Liquid Membranes for Wastewater Treatment: Equilibrium Models for Some Typical Metal-Extractant Systems journal June 1994
High throughput screening assay systems in microscale fluidic devices patent November 2000
Focusing of microparticles in microfluidic systems patent July 2003
Microchip Device for Performing Enzyme Assays journal September 1997
Distribution of Macropores in Silica Particles Prepared by Using Multiple Emulsions journal October 2002
Monodisperse Double Emulsions Generated from a Microcapillary Device journal April 2005
High throughput screening assay systems in microscale fluidic devices patent August 2001
Measurement of the Number of Molecules of a Single mRNA Species in a Complex mRNA Preparation journal April 2003
Stabilized capillary microjet and devices and methods for producing same patent March 2002
Chemical amplification based on fluid partitioning patent May 2006
Fabrication of linear colloidal structures for microfluidic applications journal August 2002

Related Subjects