Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production

Jessen, Holly Jean; Liao, Hans H; Gort, Steven John; Selifonova, Olga V

Title: Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production

Patent · Tue Nov 18 00:00:00 EST 2014

OSTI ID:1164042

Jessen, Holly Jean; Liao, Hans H; Gort, Steven John; Selifonova, Olga V

The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing such enzymes, as well as methods of their use, for example to produce malonyl semialdehyde and downstream products thereof, such as 3-hydroxypropionic acid and derivatives thereof.

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Research Organization:: Cargill, Incorporated, Wayzata, MN (United States)

Sponsoring Organization:: USDOE

Assignee:: Cargill, Incorporated (Wayzata, MN)

Patent Number(s):: 8,889,391

Application Number:: 13/230,217

OSTI ID:: 1164042

Country of Publication:: United States

Language:: English

References (16)

Polynucleotides Omura, Satoshi; Ikeda, Haruo; Ishikawa, Jun https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7630836 US Patent Document 7,630,836	patent	December 2009
Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production Jessen, Holly Jean; Liao, Hans H.; Gort, Steven John https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8030045 US Patent Document 8,030,045	patent	October 2011
Novel polynucleotides Omura, Satoshi; Ikeda, Haruo; Ishikawa, Jun https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030119018 US Patent Application 10/156761; 20030119018	patent-application	June 2003
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) Bentley, S. D.; Chater, K. F.; Cerdeño-Tárraga, A. -M. Nature, Vol. 417, Issue 6885 https://doi.org/10.1038/417141a	journal	May 2002
Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids Broun, Pierre; Shanklin, John; Whittle, Ed Science, Vol. 282, Issue 5392, p. 1315-1317 https://doi.org/10.1126/science.282.5392.1315	journal	November 1998
Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design Chica, Roberto A.; Doucet, Nicolas; Pelletier, Joelle N. Current Opinion in Biotechnology, Vol. 16, Issue 4, p. 378-384 https://doi.org/10.1016/j.copbio.2005.06.004	journal	August 2005
Practical limits of function prediction Devos, Damien; Valencia, Alfonso Proteins: Structure, Function, and Genetics, Vol. 41, Issue 1, p. 98-107 https://doi.org/10.1002/1097-0134(20001001)41:1<98::AID-PROT120>3.0.CO;2-S	journal	January 2000
Protein tolerance to random amino acid change Guo, H. H.; Choe, J.; Loeb, L. A. Proceedings of the National Academy of Sciences, Vol. 101, Issue 25, p. 9205-9210 https://doi.org/10.1073/pnas.0403255101	journal	June 2004
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis Ikeda, Haruo; Ishikawa, Jun; Hanamoto, Akiharu Nature Biotechnology, Vol. 21, Issue 5 https://doi.org/10.1038/nbt820	journal	April 2003
A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity Kimchi-Sarfaty, C.; Oh, J. M.; Kim, I.-W. Science, Vol. 315, Issue 5811, p. 525-528 https://doi.org/10.1126/science.1135308	journal	January 2007
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse McLeod, M. P.; Warren, R. L.; Hsiao, W. W. L. Proceedings of the National Academy of Sciences, Vol. 103, Issue 42, p. 15582-15587 https://doi.org/10.1073/pnas.0607048103	journal	October 2006
Human Catechol-O-Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure Nackley, A. G.; Shabalina, S. A.; Tchivileva, I. E. Science, Vol. 314, Issue 5807, p. 1930-1933 https://doi.org/10.1126/science.1131262	journal	December 2006
Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer Sauna, Z. E.; Kimchi-Sarfaty, C.; Ambudkar, S. V. Cancer Research, Vol. 67, Issue 20, p. 9609-9612 https://doi.org/10.1158/0008-5472.CAN-07-2377	journal	October 2007
Melamine Deaminase and Atrazine Chlorohydrolase: 98 Percent Identical but Functionally Different Seffernick, J. L.; de Souza, M. L.; Sadowsky, M. J. Journal of Bacteriology, Vol. 183, Issue 8, p. 2405-2410 https://doi.org/10.1128/JB.183.8.2405-2410.2001	journal	April 2001
Developments in Directed Evolution for Improving Enzyme Functions Sen, S.; Venkata Dasu, V.; Mandal, B. Applied Biochemistry and Biotechnology, Vol. 143, Issue 3, p. 212-223 https://doi.org/10.1007/s12010-007-8003-4	journal	August 2007
Conversion of a β-Ketoacyl Synthase to a Malonyl Decarboxylase by Replacement of the Active-Site Cysteine with Glutamine Witkowski, Andrzej; Joshi, Anil K.; Lindqvist, Ylva Biochemistry, Vol. 38, Issue 36, p. 11643-11650 https://doi.org/10.1021/bi990993h	journal	September 1999

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