Immunostimulatory nanoparticles and related compositions, methods and systems

Hoeprich, Paul D; Fischer, Nicholas O; Blanchette, Craig; Mason, Peter W

Title: Immunostimulatory nanoparticles and related compositions, methods and systems

Patent · Tue Nov 18 00:00:00 EST 2014

OSTI ID:1163992

Hoeprich, Paul D; Fischer, Nicholas O; Blanchette, Craig; Mason, Peter W

Provided herein are immunostimulatory nanolipoprotein particles and related compositions methods and systems.

View Patent

Cite

Export

Save

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Number(s):: 8,889,623

Application Number:: 12/604,362

OSTI ID:: 1163992

Country of Publication:: United States

Language:: English

References (109)

Muramyldipeptide derivatives Shiba, Tetsuo; Kotani, Shozo; Yamamura, Yuichi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4317771 US Patent Document 4,317,771	patent	March 1982
Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated Schneider, Michel; Tournier, Herve; Hyacinthe, Roland https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5393530 US Patent Document 5,393,530	patent	February 1995
Membrane scaffold proteins Sligar, Stephen G.; Bayburt, Timothy H. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7048949 US Patent Document 7,048,949	patent	May 2006
Membrane scaffold proteins Sligar, Stephen G.; Bayburt, Timothy H.; Schuler, Mary A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7083958 US Patent Document 7,083,958	patent	August 2006
Copper-catalysed ligation of azides and acetylenes Sharpless, K. Barry; Fokin, Valery; Rostovtsev, Vsevold A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7375234 US Patent Document 7,375,234	patent	May 2008
Membrane scaffold proteins Sligar, Stephen; Bayburt, Timothy; Schuler, Mary https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050182243 US Patent Application 11/033489; 20050182243	patent-application	August 2005
Nanoparticle-Based vaccine delivery system containing adjuvant Mumper, Russell; Cui, Zhengrong https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060189554 US Patent Application 10/528817; 20060189554	patent-application	August 2006
Membrane scaffold proteins and tethered membrane proteins Sligar, Stephen; Bayburt, Timothy https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060211092 US Patent Application 11/439458; 20060211092	patent-application	September 2006
In Vitro Protein Synthesis Systems For Membrane Proteins That Include Adolipoproteins And Phospholipid-Adolipoprotein Particles Kudlicki, Wieslaw; Fletcher, Julia; Katzen, Federico https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070117179 US Patent Application 11/535960; 20070117179	patent-application	May 2007
Nanoparticle-based vaccine delivery system containing adjuvant Mumper, Russell; Cui, Zhengrong https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080124350 US Patent Application 12/010468; 20080124350	patent-application	May 2008
Methods and Systems for Monitoring Production of a Target Protein In a Nanolipoprotein Particle Coleman, Matthew A.; Hoeprich, Paul D.; Arroyo, Erin S. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090136937 US Patent Application 12/118530; 20090136937	patent-application	May 2009
Nanolipoprotein Particles and Related Compositions, Methods and Systems Hoeprich, Paul D.; Fischer, Nicholas O.; Mason, Peter W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090311276 US Patent Application 12/469533; 20090311276	patent-application	December 2009
Methods and Systems for Producing Nanolipoprotein Particles Coleman, Matthew A.; Hoeprich, Paul D.; Segelke, Brent W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110059549 US Patent Application 12/118396; 20110059549	patent-application	March 2011
In Vitro Protein Synthesis Systems for Membrane Proteins that Include Adolipoproteins and Phospholipid Adolipoprotein Particles Kudlicki, Wieslaw; Fletcher, Julia; Katzen, Ferderico https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110195450 US Patent Application 12/848017; 20110195450	patent-application	August 2011
Modulation of human erg K⁺ channel gating by activation of a G protein-coupled receptor and protein kinase C Barros, Francisco; Gómez-Varela, David; Viloria, Cristina G. The Journal of Physiology, Vol. 511, Issue 2, p. 333-346 https://doi.org/10.1111/j.1469-7793.1998.333bh.x	journal	September 1998
Assembly of single bacteriorhodopsin trimers in bilayer nanodiscs Bayburt, Timothy H.; Grinkova, Yelena V.; Sligar, Stephen G. Archives of Biochemistry and Biophysics, Vol. 450, Issue 2, p. 215-222 https://doi.org/10.1016/j.abb.2006.03.013	journal	June 2006
Reconstitution and Imaging of a Membrane Protein in a Nanometer-Size Phospholipid Bilayer Bayburt, Timothy H.; Carlson, Joseph W.; Sligar, Stephen G. Journal of Structural Biology, Vol. 123, Issue 1 https://doi.org/10.1006/jsbi.1998.4007	journal	September 1998
Self-assembly of single integral membrane proteins into soluble nanoscale phospholipid bilayers Bayburt, Timothy H.; Sligar, Stephen G. Protein Science, Vol. 12, Issue 11, p. 2476-2481 https://doi.org/10.1110/ps.03267503	journal	November 2003
Self-Assembly of Discoidal Phospholipid Bilayer Nanoparticles with Membrane Scaffold Proteins Bayburt, Timothy H.; Grinkova, Yelena V.; Sligar, Stephen G. Nano Letters, Vol. 2, Issue 8, p. 853-856 https://doi.org/10.1021/nl025623k	journal	August 2002
Bacterial Rhodopsin: Evidence for a New Type of Phototrophy in the Sea Beja, O.; Aravind, L.; Koonin, Eugene V. Science, Vol. 289, Issue 5486, p. 1902-1906 https://doi.org/10.1126/science.289.5486.1902	journal	September 2000
Specific targeting of a lipophilic prodrug of iododeoxyuridine to parenchymal liver cells using lactosylated reconstituted high density lipoprotein particles Bijsterbosch, Martin K.; van de Bilt, Hendrika; van Berkel, Theo J. C. Biochemical Pharmacology, Vol. 52, Issue 1, p. 113-121 https://doi.org/10.1016/0006-2952(96)00170-0	journal	July 1996
Specific Interaction and Two-Dimensional Crystallization of Histidine Tagged Yeast RNA Polymerase I on Nickel-Chelating Lipids Bischler, Nicolas; Balavoine, Fabrice; Milkereit, Philipp Biophysical Journal, Vol. 74, Issue 3, p. 1522-1532 https://doi.org/10.1016/S0006-3495(98)77864-6	journal	March 1998
Atomic force microscopy differentiates discrete size distributions between membrane protein containing and empty nanolipoprotein particles Blanchette, Craig D.; Cappuccio, Jenny A.; Kuhn, Edward A. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1788, Issue 3, p. 724-731 https://doi.org/10.1016/j.bbamem.2008.11.019	journal	March 2009
Characterization and Purification of Polydisperse Reconstituted Lipoproteins and Nanolipoprotein Particles Blanchette, Craig; Segelke, Brent; Fischer, Nicholas International Journal of Molecular Sciences, Vol. 10, Issue 7 https://doi.org/10.3390/ijms10072958	journal	July 2009
Quantifying size distributions of nanolipoprotein particles with single-particle analysis and molecular dynamic simulations Blanchette, Craig D.; Law, Richard; Benner, W. Henry Journal of Lipid Research, Vol. 49, Issue 7 https://doi.org/10.1194/jlr.M700586-JLR200	journal	April 2008
Do Recombinant Receptor Assays Provide Affinity and Provide Estimates? Bockaert, JoËL; Brand, CÉLine; Journot, Laurent Annals of the New York Academy of Sciences, Vol. 812, Issue 1 Receptor Clas https://doi.org/10.1111/j.1749-6632.1997.tb48146.x	journal	May 1997
Nanodiscs separate chemoreceptor oligomeric states and reveal their signaling properties Boldog, T.; Grimme, S.; Li, M. Proceedings of the National Academy of Sciences, Vol. 103, Issue 31, p. 11509-11514 https://doi.org/10.1073/pnas.0604988103	journal	July 2006
Nanodiscs for Immobilization of Lipid Bilayers and Membrane Receptors: Kinetic Analysis of Cholera Toxin Binding to a Glycolipid Receptor Borch, Jonas; Torta, Federico; Sligar, Stephen G. Analytical Chemistry, Vol. 80, Issue 16, p. 6245-6252 https://doi.org/10.1021/ac8000644	journal	August 2008
Chemoselective Attachment of Biologically Active Proteins to Surfaces by Expressed Protein Ligation and Its Application for “Protein Chip” Fabrication Camarero, Julio A.; Kwon, Youngeun; Coleman, Matthew A. Journal of the American Chemical Society, Vol. 126, Issue 45, p. 14730-14731 https://doi.org/10.1021/ja0456611	journal	November 2004
Cell-free Co-expression of Functional Membrane Proteins and Apolipoprotein, Forming Soluble Nanolipoprotein Particles Cappuccio, Jenny A.; Blanchette, Craig D.; Sulchek, Todd A. Molecular & Cellular Proteomics, Vol. 7, Issue 11 https://doi.org/10.1074/mcp.M800191-MCP200	journal	July 2008
CpG oligodeoxynucleotides as DNA adjuvants in vertebrates and their applications in immunotherapy Chaung, Hso-Chi International Immunopharmacology, Vol. 6, Issue 10, p. 1586-1596 https://doi.org/10.1016/j.intimp.2006.06.001	journal	October 2006
Progress towards the easier use of P450 enzymes Chefson, Amandine; Auclair, Karine Molecular BioSystems, Vol. 2, Issue 10 https://doi.org/10.1039/B607001A	journal	January 2006
Attaching histidine-tagged peptides and proteins to lipid-based carriers through use of metal-ion-chelating lipids Chikh, Ghania G.; Li, Wai Ming; Schutze-Redelmeier, Marie-Paule Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1567, p. 204-212 https://doi.org/10.1016/S0005-2736(02)00618-1	journal	December 2002
Stability of pressure-extruded liposomes made from archaeobacterial ether lipids Choquet, C. G.; Patel, G. B.; Sprott, G. D. Applied Microbiology and Biotechnology, Vol. 42, Issue 2-3, p. 375-384 https://doi.org/10.1007/BF00902745	journal	November 1994
Different Apolipoproteins Impact Nanolipoprotein Particle Formation Chromy, Brett A.; Arroyo, Erin; Blanchette, Craig D. Journal of the American Chemical Society, Vol. 129, Issue 46, p. 14348-14354 https://doi.org/10.1021/ja074753y	journal	November 2007
Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo Dalpke, Alexander H.; Zimmermann, Stefan; Albrecht, Inka Immunology, Vol. 106, Issue 1 https://doi.org/10.1046/j.1365-2567.2002.01410.x	journal	May 2002
Surface changes induced by osmotic shrinkage on large unilamellar vesicles Disalvo, E. A.; Campos, A. M.; Abuin, E. Chemistry and Physics of Lipids, Vol. 84, Issue 1, p. 35-45 https://doi.org/10.1016/S0009-3084(96)02617-5	journal	November 1996
Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ET _B receptor, NADPH oxidase and caveolin-1 Dong, Feng; Zhang, Xiaochun; Wold, Loren E. British Journal of Pharmacology, Vol. 145, Issue 3 https://doi.org/10.1038/sj.bjp.0706193	journal	June 2005
Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice Dumartin, B.; Jaber, M.; Gonon, F. Proceedings of the National Academy of Sciences, Vol. 97, Issue 4, p. 1879-1884 https://doi.org/10.1073/pnas.97.4.1879	journal	February 2000
Immobilization of Active Hydrogenases by Encapsulation in Polymeric Porous Gels Elgren, Timothy E.; Zadvorny, Oleg A.; Brecht, Eric Nano Letters, Vol. 5, Issue 10, p. 2085-2087 https://doi.org/10.1021/nl0512224	journal	October 2005
Immobilization of His-Tagged Proteins on Nickel-Chelating Nanolipoprotein Particles Fischer, Nicholas O.; Blanchette, Craig D.; Chromy, Brett A. Bioconjugate Chemistry, Vol. 20, Issue 3 https://doi.org/10.1021/bc8003155	journal	March 2009
Conjugation to Nickel-Chelating Nanolipoprotein Particles Increases the Potency and Efficacy of Subunit Vaccines to Prevent West Nile Encephalitis Fischer, Nicholas O.; Infante, Ernesto; Ishikawa, Tomohiro Bioconjugate Chemistry, Vol. 21, Issue 6, p. 1018-1022 https://doi.org/10.1021/bc100083d	journal	June 2010
Carboxyl-Terminal Domain of Human Apolipoprotein E: Expression, Purification, and Crystallization Forstner, Michael; Peters-Libeu, Clare; Contreras-Forrest, Emeline Protein Expression and Purification, Vol. 17, Issue 2 https://doi.org/10.1006/prep.1999.1144	journal	November 1999
The shape of things to come: The Shape of Things To Come Drucker, Peter F. Leader to Leader, Vol. 1996, Issue 1 https://doi.org/10.1002/ltl.40619960306	journal	June 1996
Electron microscopic study on reassembly of plasma high density apoprotein with various lipids Forte, T. M.; Nichols, A. V.; Gong, E. L. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 248, Issue 2, p. 381-386 https://doi.org/10.1016/0005-2760(71)90026-9	journal	November 1971
Charge‐reduced nano electrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses Bacher, Gerold; Szymanski, Wladyslaw W.; Kaufman, Stanley L. Journal of Mass Spectrometry, Vol. 36, Issue 9, p. 1038-1052 https://doi.org/10.1002/jms.208	journal	September 2001
Negative and positive ion matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry and positive ion nano‐electrospray ionization quadrupole ion trap mass spectrometry of peptidoglycan fragments isolated from various Bacillus species Bacher, Gerold; Körner, Roman; Atrih, Abdelmadjid Journal of Mass Spectrometry, Vol. 36, Issue 2, p. 124-139 https://doi.org/10.1002/jms.109	journal	February 2001
Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only Giannini, S.; Hanon, E.; Moris, P. Vaccine, Vol. 24, Issue 33-34 https://doi.org/10.1016/j.vaccine.2006.06.005	journal	August 2006
Hydrogen Production under Aerobic Conditions by Membrane-Bound Hydrogenases from Ralstonia Species Goldet, Gabrielle; Wait, Annemarie F.; Cracknell, James A. Journal of the American Chemical Society, Vol. 130, Issue 33 https://doi.org/10.1021/ja8027668	journal	August 2008
Adjuvants for human vaccines—current status, problems and future prospects Gupta, Rajesh K.; Siber, George R. Vaccine, Vol. 13, Issue 14, p. 1263-1276 https://doi.org/10.1016/0264-410X(95)00011-O	journal	January 1995
Complex of Human Apolipoprotein C-1 with Phospholipid: Thermodynamic or Kinetic Stability? ^† Gursky, Olga; Gantz, Donald L. Biochemistry, Vol. 41, Issue 23 https://doi.org/10.1021/bi025588w	journal	June 2002
Pharmaceutical analysis of synthetic lipid A-based vaccine adjuvants in poly (d,l-lactic-co-glycolic acid) nanoparticle formulations Hamdy, Samar; Haddadi, Azita; Somayaji, Vishwa Journal of Pharmaceutical and Biomedical Analysis, Vol. 44, Issue 4, p. 914-923 https://doi.org/10.1016/j.jpba.2007.03.010	journal	August 2007
Corticotropin Releasing Factor (CRF) Receptor Signaling in the Central Nervous System: New Molecular Targets Hauger, Richard; Risbrough, Victoria; Brauns, Olaf CNS & Neurological Disorders - Drug Targets, Vol. 5, Issue 4 https://doi.org/10.2174/187152706777950684	journal	August 2006
Energy-Converting [NiFe] Hydrogenases from Archaea and Extremophiles: Ancestors of Complex I Hedderich, Reiner Journal of Bioenergetics and Biomembranes, Vol. 36, Issue 1 https://doi.org/10.1023/B:JOBB.0000019599.43969.33	journal	February 2004
Click Chemistry, A Powerful Tool for Pharmaceutical Sciences Hein, Christopher D.; Liu, Xin-Ming; Wang, Dong Pharmaceutical Research, Vol. 25, Issue 10 https://doi.org/10.1007/s11095-008-9616-1	journal	May 2008
Influence of liposome charge and composition on their interaction with human blood serum proteins Hernández-Caselles, Trinidad; Villalaín, José; Gómez-Fernández, Juan C. Molecular and Cellular Biochemistry, Vol. 120, Issue 2, p. 119-126 https://doi.org/10.1007/BF00926084	journal	January 1993
Fabrication of biomolecule–copolymer hybrid nanovesicles as energy conversion systems Ho, Dean; Chu, Benjamin; Lee, Hyeseung Nanotechnology, Vol. 16, Issue 12 https://doi.org/10.1088/0957-4484/16/12/066	journal	November 2005
G-Protein-Coupled Receptor Microarrays for Multiplexed Compound Screening Hong, Yulong; Webb, Brian L.; Pai, Sadashiva Journal of Biomolecular Screening, Vol. 11, Issue 4 https://doi.org/10.1177/1087057106287139	journal	June 2006
Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin Huleatt, James W.; Nakaar, Valerian; Desai, Priyanka Vaccine, Vol. 26, Issue 2, p. 201-214 https://doi.org/10.1016/j.vaccine.2007.10.062	journal	January 2008
Indium-111 Labeling of Low Density Lipoproteins with the DTPA−Bis(stearylamide): Evaluation as a Potential Radiopharmaceutical for Tumor Localization Jasanada, François; Urizzi, Pascale; Souchard, Jean-Pierre Bioconjugate Chemistry, Vol. 7, Issue 1 https://doi.org/10.1021/bc950073l	journal	January 1996
Thermotolerant Hydrogenases: Biological Diversity, Properties, and Biotechnological Applications Eberly, Jed O.; Ely, Roger L. Critical Reviews in Microbiology, Vol. 34, Issue 3-4 https://doi.org/10.1080/10408410802240893	journal	January 2008
Functional Cell-free Synthesis of a Seven Helix Membrane Protein: In situ Insertion of Bacteriorhodopsin into Liposomes Kalmbach, Rolf; Chizhov, Igor; Schumacher, Miria C. Journal of Molecular Biology, Vol. 371, Issue 3, p. 639-648 https://doi.org/10.1016/j.jmb.2007.05.087	journal	August 2007
Insertion of Membrane Proteins into Discoidal Membranes Using a Cell-Free Protein Expression Approach Katzen, Federico; Fletcher, Julia E.; Yang, Jian-Ping Journal of Proteome Research, Vol. 7, Issue 8 https://doi.org/10.1021/pr800265f	journal	August 2008
Cell-free expression as an emerging technique for the large scale production of integral membrane protein Klammt, Christian; Schwarz, Daniel; Lohr, Frank FEBS Journal, Vol. 273, Issue 18, p. 4141-4153 https://doi.org/10.1111/j.1742-4658.2006.05432.x	journal	September 2006
Evaluation of detergents for the soluble expression of α-helical and β-barrel-type integral membrane proteins by a preparative scale individual cell-free expression system Klammt, Christian; Schwarz, Daniel; Fendler, Klaus FEBS Journal, Vol. 272, Issue 23, p. 6024-6038 https://doi.org/10.1111/j.1742-4658.2005.05002.x	journal	November 2005
High level cell-free expression and specific labeling of integral membrane proteins Klammt, Christian; Lohr, Frank; Schafer, Birgit European Journal of Biochemistry, Vol. 271, Issue 3, p. 568-580 https://doi.org/10.1111/j.1432-1033.2003.03959.x	journal	February 2004
The growing impact of click chemistry on drug discovery Kolb, Hartmuth C.; Sharpless, K. Barry Drug Discovery Today, Vol. 8, Issue 24, p. 1128-1137 https://doi.org/10.1016/S1359-6446(03)02933-7	journal	December 2003
Steric stabilization of phospholipid vesicles by block copolymers Vesicle flocculation and osmotic swelling caused by monovalent and divalent cations Kostarelos, Kostas; Luckham, Paul F.; Tadros, Tharwat F. Journal of the Chemical Society, Faraday Transactions, Vol. 94, Issue 15 https://doi.org/10.1039/A801134F	journal	January 1998
A novel approach for biohydrogen production Kovacs, K.; Maroti, G.; Rakhely, G. International Journal of Hydrogen Energy, Vol. 31, Issue 11, p. 1460-1468 https://doi.org/10.1016/j.ijhydene.2006.06.011	journal	September 2006
Two-Dimensional Crystallization of Histidine-Tagged, HIV-1 Reverse Transcriptase Promoted by a Novel Nickel-Chelating Lipid Kubalek, Elizabeth W.; Le Grice, Stuart F. J.; Brown, Patrick O. Journal of Structural Biology, Vol. 113, Issue 2 https://doi.org/10.1006/jsbi.1994.1039	journal	September 1994
Novel applications of liposomes Lasic, D. Trends in Biotechnology, Vol. 16, Issue 7 https://doi.org/10.1016/S0167-7799(98)01220-7	journal	July 1998
Mechanical properties and stability measurement of cholesterol-containing liposome on mica by atomic force microscopy Liang, Xuemei; Mao, Guangzhao; Ng, K. Y. Simon Journal of Colloid and Interface Science, Vol. 278, Issue 1, p. 53-62 https://doi.org/10.1016/j.jcis.2004.05.042	journal	October 2004
Conformational Reorganization of the Four-helix Bundle of Human Apolipoprotein E in Binding to Phospholipid Lu, Bin; Morrow, Julie A.; Weisgraber, Karl H. Journal of Biological Chemistry, Vol. 275, Issue 27, p. 20775-20781 https://doi.org/10.1074/jbc.M003508200	journal	May 2000
Large-scale profiling of protein palmitoylation in mammalian cells Martin, Brent R.; Cravatt, Benjamin F. Nature Methods, Vol. 6, Issue 2, p. 135-138 https://doi.org/10.1038/nmeth.1293	journal	January 2009
The Vaccine Adjuvant Monophosphoryl Lipid A as a TRIF-Biased Agonist of TLR4 Mata-Haro, V.; Cekic, C.; Martin, M. Science, Vol. 316, Issue 5831, p. 1628-1632 https://doi.org/10.1126/science.1138963	journal	June 2007
[FeFe] hydrogenases and their evolution: a genomic perspective Meyer, J. Cellular and Molecular Life Sciences, Vol. 64, Issue 9, p. 1063-1084 https://doi.org/10.1007/s00018-007-6477-4	journal	March 2007
Functional Characterization of Apolipoprotein E Isoforms Overexpressed in Escherichia coli Morrow, Julie A.; Arnold, Kay S.; Weisgraber, Karl H. Protein Expression and Purification, Vol. 16, Issue 2 https://doi.org/10.1006/prep.1999.1069	journal	July 1999
Applications of Phospholipid Bilayer Nanodiscs in the Study of Membranes and Membrane Proteins ^† Nath, Abhinav; Atkins, William M.; Sligar, Stephen G. Biochemistry, Vol. 46, Issue 8 https://doi.org/10.1021/bi602371n	journal	February 2007
A Potent Adjuvant Monophosphoryl Lipid A Triggers Various Immune Responses, but Not Secretion of IL-1β or Activation of Caspase-1 Okemoto, Kazuo; Kawasaki, Kiyoshi; Hanada, Kentaro The Journal of Immunology, Vol. 176, Issue 2 https://doi.org/10.4049/jimmunol.176.2.1203	journal	January 2006
The Difference a Se Makes? Oxygen-Tolerant Hydrogen Production by the [NiFeSe]-Hydrogenase from Desulfomicrobium baculatum Parkin, Alison; Goldet, Gabrielle; Cavazza, Christine Journal of the American Chemical Society, Vol. 130, Issue 40 https://doi.org/10.1021/ja803657d	journal	October 2008
In-depth analysis of the membrane and cytosolic proteome of red blood cells Pasini, Erica M.; Kirkegaard, Morten; Mortensen, Peter Blood, Vol. 108, Issue 3 https://doi.org/10.1182/blood-2005-11-007799	journal	August 2006
Preparation and Characterization of Nickel Nanoparticles for Binding to His-tag Proteins and Antigens Patel, Jigna D.; O’Carra, Ronan; Jones, Julia Pharmaceutical Research, Vol. 24, Issue 2 https://doi.org/10.1007/s11095-006-9154-7	journal	December 2006
Taking toll: lipid A mimetics as adjuvants and immunomodulators Persing, David H.; Coler, Rhea N.; Lacy, Michael J. Trends in Microbiology, Vol. 10, Issue 10, p. s32-s37 https://doi.org/10.1016/S0966-842X(02)02426-5	journal	October 2002
Topology prediction of membrane proteins Argos, Patrick; Persson, Bengt Protein Science, Vol. 5, Issue 2 https://doi.org/10.1002/pro.5560050221	journal	February 1996
Noncytopathic Replication of Venezuelan Equine Encephalitis Virus and Eastern Equine Encephalitis Virus Replicons in Mammalian Cells Petrakova, O.; Volkova, E.; Gorchakov, R. Journal of Virology, Vol. 79, Issue 12 https://doi.org/10.1128/JVI.79.12.7597-7608.2005	journal	May 2005
The Effects of Deleting the Mouse Neurotensin Receptor NTR1 on Central and Peripheral Responses to Neurotensin Pettibone, Douglas J.; Hess, J. Fred; Hey, Patricia J. Journal of Pharmacology and Experimental Therapeutics, Vol. 300, Issue 1 https://doi.org/10.1124/jpet.300.1.305	journal	January 2002
Comparison of Multiplexed Techniques for Detection of Bacterial and Viral Proteins Rao, Rupa S.; Visuri, Steven R.; McBride, Mary T. Journal of Proteome Research, Vol. 3, Issue 4, p. 736-742 https://doi.org/10.1021/pr034130t	journal	August 2004
Two-Dimensional Streptavidin Crystals on Giant Lipid Bilayer Vesicles Ratanabanangkoon, Pasut; Gropper, Michael; Merkel, Rudolf Langmuir, Vol. 18, Issue 11, p. 4270-4276 https://doi.org/10.1021/la025568v	journal	May 2002
Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor Ren, X.-R.; Reiter, E.; Ahn, S. Proceedings of the National Academy of Sciences, Vol. 102, Issue 5, p. 1448-1453 https://doi.org/10.1073/pnas.0409534102	journal	January 2005
Generation of immunoliposomes using recombinant single-chain Fv fragments bound to Ni-NTA-liposomes Rüger, Ronny; Müller, Dafne; Fahr, Alfred Journal of Drug Targeting, Vol. 13, Issue 7 https://doi.org/10.1080/10611860500353328	journal	August 2005
In vitro characterization of binding and stability of single-chain Fv Ni-NTA-liposomes Rüger, Ronny; Müller, Dafne; Fahr, Alfred Journal of Drug Targeting, Vol. 14, Issue 8 https://doi.org/10.1080/10611860600864018	journal	January 2006
Chemistry: The photon trap Sanderson, Katharine Nature, Vol. 452, Issue 7186 https://doi.org/10.1038/452400a	journal	March 2008
A simple energy-conserving system: Proton reduction coupled to proton translocation Sapra, R.; Bagramyan, K.; Adams, M. W. W. Proceedings of the National Academy of Sciences, Vol. 100, Issue 13, p. 7545-7550 https://doi.org/10.1073/pnas.1331436100	journal	June 2003
Synthesis and Characterization of Chelator-Lipids for Reversible Immobilization of Engineered Proteins at Self-Assembled Lipid Interfaces Schmitt, Lutz; Dietrich, Christian; Tampe, Robert Journal of the American Chemical Society, Vol. 116, Issue 19, p. 8485-8491 https://doi.org/10.1021/ja00098a008	journal	September 1994
Molecular Dynamics Simulations of Discoidal Bilayers Assembled from Truncated Human Lipoproteins Shih, Amy Y.; Denisov, Ilia G.; Phillips, James C. Biophysical Journal, Vol. 88, Issue 1 https://doi.org/10.1529/biophysj.104.046896	journal	January 2005
Membrane-Mimetic Films of Asymmetric Phosphatidylcholine Lipid Bolaamphiphiles Sun, Xue-Long; Biswas, Nilanjana; Kai, Toshitsugu Langmuir, Vol. 22, Issue 3 https://doi.org/10.1021/la052125t	journal	January 2006
Overview of tag protein fusions: from molecular and biochemical fundamentals to commercial systems Terpe, K. Applied Microbiology and Biotechnology, Vol. 60, Issue 5, p. 523-533 https://doi.org/10.1007/s00253-002-1158-6	journal	January 2003
Peptide stabilized amphotericin B nanodisks Tufteland, Megan; Pesavento, Joseph B.; Bermingham, Rachelle L. Peptides, Vol. 28, Issue 4, p. 741-746 https://doi.org/10.1016/j.peptides.2007.01.007	journal	April 2007
Induction of tumor necrosis factor-α in solid tumor region by the orally administered synthetic muramyl dipeptide analogue, romurtide Ueda, Hiroshi; Yamazaki, Masatoshi International Immunopharmacology, Vol. 1, Issue 1, p. 97-104 https://doi.org/10.1016/S1567-5769(00)00017-5	journal	January 2001
Vaccine manufacturing: challenges and solutions Ulmer, Jeffrey B.; Valley, Ulrich; Rappuoli, Rino Nature Biotechnology, Vol. 24, Issue 11 https://doi.org/10.1038/nbt1261	journal	November 2006
Occurrence, Classification, and Biological Function of Hydrogenases: An Overview Vignais, Paulette M.; Billoud, Bernard Chemical Reviews, Vol. 107, Issue 10, p. 4206-4272 https://doi.org/10.1021/cr050196r	journal	October 2007
Investigating and Exploiting the Electrocatalytic Properties of Hydrogenases Vincent, Kylie A.; Parkin, Alison; Armstrong, Fraser A. Chemical Reviews, Vol. 107, Issue 10, p. 4366-4413 https://doi.org/10.1021/cr050191u	journal	October 2007
From The Cover: Electrocatalytic hydrogen oxidation by an enzyme at high carbon monoxide or oxygen levels Vincent, K. A.; Cracknell, J. A.; Lenz, O. Proceedings of the National Academy of Sciences, Vol. 102, Issue 47, p. 16951-16954 https://doi.org/10.1073/pnas.0504499102	journal	October 2005
CpG DNA induces stronger immune responses with less toxicity than other adjuvants Weeratna, Risini D.; McCluskie, Michael J.; Xu, Yu Vaccine, Vol. 18, Issue 17, p. 1755-1762 https://doi.org/10.1016/S0264-410X(99)00526-5	journal	March 2000
Construction and characterization of a second-generation pseudoinfectious West Nile virus vaccine propagated using a new cultivation system Widman, Douglas G.; Ishikawa, Tomohiro; Fayzulin, Rafik Vaccine, Vol. 26, Issue 22, p. 2762-2771 https://doi.org/10.1016/j.vaccine.2008.03.009	journal	May 2008
In vitro hydrogen production by glucose dehydrogenase and hydrogenase Woodward, Jonathan; Mattingly, Susan M.; Danson, Michael Nature Biotechnology, Vol. 14, Issue 7, p. 872-874 https://doi.org/10.1038/nbt0796-872	journal	July 1996
Enzymatic production of biohydrogen: Biotechnology Woodward, Jonathan; Orr, Mark; Cordray, Kimberley Nature, Vol. 405, Issue 6790, p. 1014-1015 https://doi.org/10.1038/35016633	journal	June 2000
High yield cell-free production of integral membrane proteins without refolding or detergents Wuu, Jessica J.; Swartz, James R. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1778, Issue 5, p. 1237-1250 https://doi.org/10.1016/j.bbamem.2008.01.023	journal	May 2008
Immunostimulatory DNA as adjuvant: efficacy of phosphodiester CpG oligonucleotides is enhanced by 3′ sequence modifications Zimmermann, Stefan; Heeg, Klaus; Dalpke, Alexander Vaccine, Vol. 21, Issue 9-10, p. 990-995 https://doi.org/10.1016/S0264-410X(02)00550-9	journal	February 2003

Similar Records

Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems

Patent · Tue Mar 23 00:00:00 EDT 2021 · OSTI ID:1163992

Rieder, Aida Elizabeth; De Los Santos, Teresa B.; Rodriguez, Luis Miguel; +3 more

MOMP telonanoparticles, and related compositions, methods and systems

Patent · Tue Dec 28 00:00:00 EST 2021 · OSTI ID:1163992

Coleman, Matthew A.; Fischer, Nicholas O.; Rasley, Amy; +2 more

Genetically engineered foot and mouth disease virus and related proteins, polynucleotides, compositions, methods and systems

Patent · Tue Nov 14 00:00:00 EST 2023 · OSTI ID:1163992

Rieder, Aida E.; De Los Santos, Teresa B.; Rodriguez, Luis L.; +3 more

Related Subjects

60 APPLIED LIFE SCIENCES
77 NANOSCIENCE AND NANOTECHNOLOGY

Title: Immunostimulatory nanoparticles and related compositions, methods and systems

Citation Formats

References (109)

Similar Records

Related Subjects