skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods for making nucleotide probes for sequencing and synthesis

Patent ·
OSTI ID:1140127
; ;

Compositions and methods for making a plurality of probes for analyzing a plurality of nucleic acid samples are provided. Compositions and methods for analyzing a plurality of nucleic acid samples to obtain sequence information in each nucleic acid sample are also provided.

Research Organization:
Harvard College, Cambridge, MA (USA).
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-02ER63445
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Number(s):
8,771,950
Application Number:
12/187,460
OSTI ID:
1140127
Country of Publication:
United States
Language:
English

References (45)

Process for amplifying, detecting, and/or-cloning nucleic acid sequences patent July 1987
Process for amplifying nucleic acid sequences patent July 1987
Process for amplifying, detecting, and/or cloning nucleic acid sequences patent January 1989
Detection of specific sequences in nucleic acids patent November 1989
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme patent October 1990
Homogeneous assay system using the nuclease activity of a nucleic acid polymerase patent May 1993
Nucleic acid sequence amplification methods patent March 1995
Method to detect mutations in a nucleic acid using a hybridization-ligation procedure patent February 1999
Circularizing nucleic acid probe able to interlock with a target sequence through catenation patent February 1999
Monitoring amplification of DNA during PCR patent January 2001
Rolling circle replication reporter systems patent February 2001
Nucleic acid ligand inhibitors to DNA polymerases patent February 2001
Nucleic acid detecting reagent patent May 2001
Allele detection using primer extension with sequence-coded identity tags patent September 2001
Methods for reducing the complexity of DNA sequences patent September 2001
Method for producing a tobacco filter material patent February 2002
Replica amplification of nucleic acid arrays patent August 2002
Replica amplification of nucleic acid arrays patent November 2002
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays patent January 2003
Replica amplification of nucleic acid arrays patent January 2003
Identification of alleles patent March 2004
Direct multiplex characterization of genomic DNA patent February 2005
Nucleic acid detection methods using universal priming patent-application January 2003
Multiplex PCR patent-application June 2003
Nucleic acid memory device patent-application December 2003
Direct Multiplex Characterization of Genomic DNA patent-application May 2004
DNA polymerase blends and uses thereof patent-application October 2004
Monitoring for and detecting microbes used in bioterrorism patent-application December 2004
Methods and compositions for whole genome amplification and genotyping patent-application February 2005
Method of oligonucleotide synthesis patent-application July 2005
Nucleic acid hybridization methods patent-application August 2005
Parallel gene analysis with allele-specific padlock probes and tag microarrays journal September 2003
Sequencing genomes from single cells by polymerase cloning journal May 2006
Highly multiplexed molecular inversion probe genotyping: Over 10,000 targeted SNPs genotyped in a single tube assay journal January 2005
Cell-free cloning using φ29 DNA polymerase journal November 2005
Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery journal October 2005
The mechanisms of DNA topoisomerases journal April 1995
Allelic Variation in Human Gene Expression journal August 2002
Accurate multiplex gene synthesis from programmable DNA microchips journal December 2004
Toward genome-wide SNP genotyping journal June 2005
Mutation detection by solid phase primer extension journal January 1996
Multiplexed genotyping with sequence-tagged molecular inversion probes journal May 2003
Mutation detection and single-molecule counting using isothermal rolling-circleamplification journal July 1998
Universal DNA microarray method for multiplex detection of low abundance point mutations journal September 1999
Circle-to-circle amplification for precise and sensitive DNA analysis journal March 2004

Cited By (1)

Methods for making nucleotide probes for sequencing and synthesis patent July 2014

Similar Records

Related Subjects

60 APPLIED LIFE SCIENCES