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Title: Apparatus and method of dissociating ions in a multipole ion guide

Patent ·
OSTI ID:1137094
; ; ; ;

A method of dissociating ions in a multipole ion guide is disclosed. A stream of charged ions is supplied to the ion guide. A main RF field is applied to the ion guide to confine the ions through the ion guide. An excitation RF field is applied to one pair of rods of the ion guide. The ions undergo dissociation when the applied excitation RF field is resonant with a secular frequency of the ions. The multipole ion guide is, but not limited to, a quadrupole, a hexapole, and an octopole.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
8,772,711
Application Number:
14/011,529
OSTI ID:
1137094
Country of Publication:
United States
Language:
English

References (13)

Method of and apparatus for selective collision-induced dissociation of ions in a quadrupole ion guide patent January 2003
Mass spectrometry with multipole ion guides patent June 2004
High-Q pulsed fragmentation in ion traps patent September 2005
Mass spectrometry with segmented RF multiple ion guides in various pressure regions patent April 2006
Mass spectrometry with segmented RF multiple ion guides in various pressure regions patent December 2010
High performance micro-fabricated electrostatic quadrupole lens patent-application August 2008
The focusing of an ion beam from a quadrupole mass filter using an electrostatic octopole lens journal October 1978
High amplitude short time excitation: A method to form and detect low mass product ions in a quadrupole ion trap mass spectrometer journal January 2006
MS3 using the collision cell of a tandem mass spectrometer system journal January 2002
A new technique for decomposition of selected ions in molecule ion reactor coupled with ortho-time-of-flight mass spectrometry journal October 1997
Proteomics on an Orbitrap Benchtop Mass Spectrometer Using All-ion Fragmentation journal July 2010
Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis journal January 2012
Establishing low-energy sequential decomposition pathways of leucine enkephalin and its N- and C-terminus fragments using multiple-resonance CID in quadrupolar ion guide journal December 2004

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