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Title: Catheter based mid-infrared reflectance and reflectance generated absorption spectroscopy

Patent ·
OSTI ID:1107628

A method of characterizing conditions in a tissue, by (a) providing a catheter that has a light source that emits light in selected wavenumbers within the range of mid-IR spectrum; (b) directing the light from the catheter to an area of tissue at a location inside a blood vessel of a subject; (c) collecting light reflected from the location and generating a reflectance spectra; and (d) comparing the reflectance spectra to a reference spectra of normal tissue, whereby a location having an increased number of absorbance peaks at said selected wavenumbers indicates a tissue inside the blood vessel containing a physiological marker for atherosclerosis.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
8,571,640
Application Number:
10/582,422
OSTI ID:
1107628
Country of Publication:
United States
Language:
English

References (7)

Systems and methods of molecular spectroscopy to provide for the diagnosis of tissue patent February 2004
Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy patent March 1994
Catheter for laser angiosurgery patent April 1990
Luminal diagnostics employing spectral analysis patent October 2000
Mid-infrared reflectivity of experimental atheromas journal January 2008
Multichannel gas analyzer and method of use patent March 1989
Near infrared diagnostic method and instrument patent March 1993

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