Labeled ALPHA4BETA2 ligands and methods therefor

Mukherjee, Jogeshwar; Pichika, Ramaiah; Potkin, Steven; Leslie, Frances; Chattopadhyay, Sankha

Title: Labeled ALPHA4BETA2 ligands and methods therefor

Patent · Tue Feb 19 00:00:00 EST 2013

OSTI ID:1082891

Mukherjee, Jogeshwar; Pichika, Ramaiah; Potkin, Steven; Leslie, Frances; Chattopadhyay, Sankha

Contemplated compositions and methods are employed to bind in vitro and in vivo to an .alpha.4.beta.2 nicotinic acetylcholine receptor in a highly selective manner. Where such compounds are labeled, compositions and methods employing such compounds can be used for PET and SPECT analysis. Alternatively, and/or additionally contemplated compounds can be used as antagonists, partial agonists or agonists in the treatment of diseases or conditions associated with .alpha.4.beta..beta.2 dysfunction.

View Patent

Cite

Export

Save

Research Organization:: DOESC (USDOE Office of Science (SC) (United States))

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-03ER63598

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,378,109

Application Number:: 11/721,145

OSTI ID:: 1082891

Country of Publication:: United States

Language:: English

References (9)

3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release Abreo, Melwyn; Gunn, David; Lin, Nan-Horng https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5948793 US Patent Document 5,948,793	patent	September 1999
Nicotine derivatives that enhance cognitive function Lin, Nan-Horng https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5278176 US Patent Document 5,278,176	patent	January 1994
3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission Lin, Nan-Horng; He, Yun; Holladay, Mark W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5629325 US Patent Document 5,629,325	patent	May 1997
Heterocyclic ether compounds useful in controlling neurotransmitter release Lin, Nan-Horng; Holladay, Mark W.; Abreo, Melwyn https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5914328 US Patent Document 5,914,328	patent	June 1999
Development of ligands for in vivo imaging of cerebral nicotinic receptors Sihver, Wiebke; Nordberg, Agneta; Långström, Bengt Behavioural Brain Research, Vol. 113, Issue 1-2 https://doi.org/10.1016/S0166-4328(00)00209-6	journal	August 2000
Structure−Activity Studies on 2-Methyl-3-(2( S )-pyrrolidinylmethoxy)pyridine (ABT-089): An Orally Bioavailable 3-Pyridyl Ether Nicotinic Acetylcholine Receptor Ligand with Cognition-Enhancing Properties Lin, Nan-Horng; Gunn, David E.; Ryther, Keith B. Journal of Medicinal Chemistry, Vol. 40, Issue 3 https://doi.org/10.1021/jm960233u	journal	January 1997
7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission Wasicak, James T.; Garvey, David S.; Holladay, Mark W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5733912 US Patent Document 5,733,912	patent	March 1998
Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist Lin, Nan-Horng; Gunn, David E.; Li, Yihong Bioorganic & Medicinal Chemistry Letters, Vol. 8, Issue 3 https://doi.org/10.1016/S0960-894X(98)00019-5	journal	February 1998
Nicotinic receptor antagonists in the treatment of neuropharmacological disorders Crooks, Peter A.; Dwoskin, Linda P.; Ravard, Alain https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5691365 US Patent Document 5,691,365	patent	November 1997

Similar Records

The effect of smoking cessation pharmacotherapies on pancreatic beta cell function

Journal Article · Thu Nov 15 00:00:00 EST 2012 · Toxicology and Applied Pharmacology · OSTI ID:1082891

Woynillowicz, Amanda K.; Raha, Sandeep; Nicholson, Catherine J.

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: ( sup 3 H)nicotine as an agonist photoaffinity label

Journal Article · Tue Jul 16 00:00:00 EDT 1991 · Biochemistry; (United States) · OSTI ID:1082891

Middleton, R E; Cohen, J B

Long-term exposure to nicotine markedly reduces kynurenic acid in rat brain - In vitro and ex vivo evidence

Journal Article · Thu Oct 15 00:00:00 EDT 2009 · Toxicology and Applied Pharmacology · OSTI ID:1082891

Zielinska, Elzbieta; Kuc, Damian; Zgrajka, Wojciech; +2 more

Related Subjects

60 APPLIED LIFE SCIENCES

Title: Labeled ALPHA4BETA2 ligands and methods therefor

Citation Formats

References (9)

Similar Records

Related Subjects