Method and apparatus for combinatorial chemistry

Foote, Robert S

Title: Method and apparatus for combinatorial chemistry

Patent · Tue Jun 05 00:00:00 EDT 2012

OSTI ID:1055721

Foote, Robert S ^[1]

Oak Ridge, TN

A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be photoactivated within a subset of channels at the site of immobilized substrate molecules or at a light-addressable site upstream from the substrate molecules. The method and apparatus of the invention find particularly utility in the synthesis of biopolymer arrays, e.g., oligonucleotides, peptides and carbohydrates, and in the combinatorial synthesis of small molecule arrays for drug discovery.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-96OR22464

Assignee:: Foote, Robert S. (Oak Ridge, TN)

Patent Number(s):: 8,193,336

Application Number:: 12/488,242

OSTI ID:: 1055721

Country of Publication:: United States

Language:: English

References (20)

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