Pioneer Valley Life Sciences Institute Program in Endocrinology and Metabolism
Specific Aim - To determine the role of TGFBeta superfamily ligands in regulating Beta-cell function, proliferation, and survival (Drs. Schneyer and Brown) Specific Aim - To determine the feasibility of using respiratory activity and extracellular acidification rates of myoblasts to decipher the state of insulin resistance in cultured myoblastsMyoblast physiology (Drs. Schwartz and Yadava)
- Research Organization:
- Pioneer Valley Life Sciences Institute, Springfield, MA
- Sponsoring Organization:
- USDOE Office of Science (SC)
- DOE Contract Number:
- SC0003684
- OSTI ID:
- 1039284
- Report Number(s):
- DOE/SC0003684
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
TGFBeta superfamily ligands
Beta-cell function
pancreatic islets
activin A and B proteins
Beta-cells in islets
myostatin
antagonist follistatin like-3 (FSTL3)
Beta-cell proliferation
transdifferentiation into Beta-cells
Beta-cell hyperplasia
myoblasts
insulin resistance
extracellular acidification rate
Facioscapulohumeral Muscular Dystrophy (FSHD)
respiratory activity
mitochondrial mass
reactive oxygen species production
primary pancreatic Beta cells
Complex I function
muscle pathophysiology
TGFBeta superfamily ligands
Beta-cell function
pancreatic islets
activin A and B proteins
Beta-cells in islets
myostatin
antagonist follistatin like-3 (FSTL3)
Beta-cell proliferation
transdifferentiation into Beta-cells
Beta-cell hyperplasia
myoblasts
insulin resistance
extracellular acidification rate
Facioscapulohumeral Muscular Dystrophy (FSHD)
respiratory activity
mitochondrial mass
reactive oxygen species production
primary pancreatic Beta cells
Complex I function
muscle pathophysiology