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Title: Composite material

Abstract

A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

Inventors:
 [1];  [2];  [3];  [1]
  1. Knoxville, TN
  2. Solihull, GB
  3. Oak Ridge, TN
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1037758
Patent Number(s):
8,110,222
Application Number:
10/295,461
Assignee:
UT-Battelle, LLC. (Oak Ridge, TN); University of Tennessee Research Foundation (Knoxville, TN)
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Hutchens, Stacy A, Woodward, Jonathan, Evans, Barbara R, and O'Neill, Hugh M. Composite material. United States: N. p., 2012. Web.
Hutchens, Stacy A, Woodward, Jonathan, Evans, Barbara R, & O'Neill, Hugh M. Composite material. United States.
Hutchens, Stacy A, Woodward, Jonathan, Evans, Barbara R, and O'Neill, Hugh M. 2012. "Composite material". United States. https://www.osti.gov/servlets/purl/1037758.
@article{osti_1037758,
title = {Composite material},
author = {Hutchens, Stacy A and Woodward, Jonathan and Evans, Barbara R and O'Neill, Hugh M},
abstractNote = {A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.},
doi = {},
url = {https://www.osti.gov/biblio/1037758}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 07 00:00:00 EST 2012},
month = {Tue Feb 07 00:00:00 EST 2012}
}

Works referenced in this record:

Inclusion of solid particles in bacterial cellulose
journal, May 2002


The Phylogeny of Acetic Acid Bacteria Based on the Partial Sequences of 16S Ribosomal RNA: The Elevation of the Subgenus Gluconoacetobacter to the Generic Level
journal, January 1997


Calcium-deficient apatite: A firstin vivo study concerning bone ingrowth
journal, May 2003


Biomaterial developments for bone tissue engineering
journal, December 2000


Bacterial synthesized cellulose — artificial blood vessels for microsurgery
journal, November 2001


Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat
journal, November 1999


Tissue biocompatibility of cellulose and its derivatives
journal, January 1989


Cellulose phosphates as biomaterials. In vivo biocompatibility studies
journal, February 2002


In vitro evaluation of a new injectable calcium phosphate material
journal, March 1998


The structure and mechanical properties of sheets prepared from bacterial cellulose
journal, September 1989


Biogenesis of Bacterial Cellulose
journal, January 1991


Biocompatibility of Cellulose Sponge with Bone
journal, January 1998


Acetobacter cellulose pellicle as a temporary skin substitute
journal, March 1990


Factors affecting Production of Cellulose at the Air/ Liquid Interface of a Culture of Acetobacter xylinum
journal, August 1954


Injectable gels for tissue engineering
journal, January 2001


Duraplasty with biosynthetic cellulose: an experimental study
journal, January 1997


Synthesis and thermal behavior of well-crystallized calcium-deficient phosphate apatite
journal, February 1989