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Title: Fluorescent sensor for mercury

Patent ·
OSTI ID:1032961
 [1];  [2];  [3]
  1. Urbana, IL
  2. Evanston, IL
  3. Champaign, IL
+ Show Author Affiliations

The present invention provides a sensor for detecting mercury, comprising: a first polynucleotide, comprising a first region, and a second region, a second polynucleotide, a third polynucleotide, a fluorophore, and a quencher, wherein the third polynucleotide is optionally linked to the second region; the fluorophore is linked to the first polynucleotide and the quencher is linked to the second polynucleotide, or the fluorophore is linked to the second polynucleotide and the quencher is linked to the first polynucleotide; the first region and the second region hybridize to the second polynucleotide; and the second region binds to the third polynucleotide in the presence of Hg.sup.2+ ions.

Research Organization:
Cornell Univ., Ithaca, NY (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-01ER63173
Assignee:
The Board of Trustees of the University of Illinois (Urbana, IL)
Patent Number(s):
8,062,893
Application Number:
12/564,715
OSTI ID:
1032961
Resource Relation:
Patent File Date: 2009 Sep 22
Country of Publication:
United States
Language:
English

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Characterization and divalent metal-ion dependence of in vitro selected deoxyribozymes which cleave DNA/RNA chimeric oligonucleotides journal June 1997
In vitro evolution of new ribozymes with polynucleotide kinase activity journal September 1994
Oligonucleotide aptamers that recognize small molecules journal June 1999
RNA Cleavage by a DNA Enzyme with Extended Chemical Functionality journal March 2000
A selective fluorescent ratiometric chemodosimeter for mercury ion journal January 2005
Solid phase extraction and determination of ultra trace amounts of mercury(II) using octadecyl silica membrane disks modified by hexathia-18-crown-6-tetraone and cold vapour atomic absorption spectrometry journal November 1997
An RNA aptamer to the xanthine/guanine base with a distinctive mode of purine recognition journal April 1998
Determination of uranium in environmental samples using inductively coupled plasma mass spectrometry journal December 1987
Simple and Rapid Colorimetric Biosensors Based on DNA Aptamer and Noncrosslinking Gold Nanoparticle Aggregation journal May 2007
Stress Corrosion Cracking and Life Prediction Evaluation of Austenitic Stainless Steels in Calcium Chloride Solution journal May 1996
Gold Nanoparticle-Based Miniaturized Nanomaterial Surface Energy Transfer Probe for Rapid and Ultrasensitive Detection of Mercury in Soil, Water, and Fish journal October 2007
A Mammalian Expression Vector for Expression and Purification of Secreted Proteins for Structural Studies journal December 2000
Detection of Specific Sequences in RNA Using Differential Adsorption of Single-Stranded Oligonucleotides on Gold Nanoparticles journal October 2005
Porphyrin Metalation Catalyzed by a Small RNA Molecule journal January 1996
Equilibria in the Systems, Water, Acetone and Inorganic Salts. journal June 1914
Six-Helix Bundles Designed from DNA journal April 2005
Optical sensors for determination of heavy metal ions journal September 1997
Light-generated oligonucleotide arrays for rapid DNA sequence analysis. journal May 1994
SURVEY AND SUMMARY: Recent advances in the elucidation of the mechanisms of action of ribozymes journal May 2001
Atomic force microscopy of oriented linear DNA molecules labeled with 5nm gold spheres journal January 1993
Controlling Gene Expression in Living Cells Through Small Molecule-RNA Interactions journal October 1998
Selection of RNA amide synthases journal September 1997
Structural Analysis of Metal Ion Ligation to Nucleotides and Nucleic Acids Using Pulsed EPR Spectroscopy journal February 2002
Synthesis, Structure, and Properties of Model Organic Surfaces journal October 1992
Liposomal encapsulated anti-cancer drugs journal January 2005
Activity Coefficients of Nonelectrolyte Solutes in Aqueous Salt Solutions. journal August 1952
Linear assemblies of nanoparticles electrostatically organized on DNA scaffolds journal March 2003
Sequence Symmetry as a Tool for Designing DNA Nanostructures journal October 2005
Accelerated Color Change of Gold Nanoparticles Assembled by DNAzymes for Simple and Fast Colorimetric Pb 2+ Detection journal October 2004
Structural basis of DNA folding and recognition in an AMP-DNA aptamer complex: distinct architectures but common recognition motifs for DNA and RNA aptamers complexed to AMP journal November 1997
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab journal February 2003
In vivo selection of spectinomycin-binding RNAs journal December 2002
Potentiometric determination of acid dissociation constants (pKa) for human and veterinary antibiotics journal July 2004
Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles journal August 1997
Membrane probe-spectral emission type detection system for mercury in water journal August 1971
Fluorescent Sensors Based on Aptamer Self-Assembly journal November 2000
Capping DNA with DNA † journal March 2000
Improving Fluorescent DNAzyme Biosensors by Combining Inter- and Intramolecular Quenchers journal December 2003
Nucleic Acid AptamersFrom Selection in Vitro to Applications in Vivo journal September 2000
Liposomal Anthracyclines in Metastatic Breast Cancer: Clinical Update journal August 2003
Peptidyl Fluorescent Chemosensors for the Detection of Divalent Copper journal April 2003
Synthesis of New Phenanthroline-Based Heteroditopic Ligands – Highly Efficient and Selective Fluorescence Sensors for Copper(II) Ions journal November 2006
Bioconjugated Nanoparticles for DNA Protection from Cleavage journal June 2003
Ratiometric Displacement Approach to Cu(II) Sensing by Fluorescence journal February 2005
Homocysteine-Mediated Reactivity and Assembly of Gold Nanoparticles journal January 2007
A General Strategy for Effector-mediated Control of RNA-cleaving Ribozymes and DNA Enzymes journal April 2002
MOLECULAR BIOLOGY: Making Catalytic DNAs journal December 2000
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells journal April 2000
Mercury toxicity in the pregnant woman, fetus, and newborn infant journal October 1976
Cofactor-Assisted Self-Cleavage in DNA Libraries with a 3′–5′-Phosphoramidate Bond journal July 1997
Stereospecific recognition of tryptophan agarose by in vitro selected RNA journal May 1992
Dissociation of Long-Chain Duplex RNA Can Occur Via Strand Displacement in Vitro: Biological Implications journal November 1996
A “Turn-On” Fluorescent Sensor for the Selective Detection of Mercuric Ion in Aqueous Media journal November 2003
The chemical repertoire of natural ribozymes journal July 2002
Interactions of uranium and thorium with arsenazo III in an aqueous medium journal April 1997
Role of Nd 3+ and Pb 2+ on the RNA Cleavage Reaction by a Small Ribozyme † journal March 1997
Site-Specific Control of Distances between Gold Nanoparticles Using Phosphorothioate Anchors on DNA and a Short Bifunctional Molecular Fastener journal December 2007
Colorimetric Detection of Mercuric Ion (Hg2+) in Aqueous Media using DNA-Functionalized Gold Nanoparticles journal May 2007
Fluorescent DNAzyme Biosensors for Metal Ions Based on Catalytic Molecular Beacons book January 2006
Surface Immobilization of Catalytic Beacons Based on Ratiometric Fluorescent DNAzyme Sensors:  A Systematic Study journal August 2007
Extraction of acetonitrile from aqueous mixtures. 2. Ternary liquid equilibriums journal July 1979
Cu 2+ -Induced Blue Shift of the Pyrene Excimer Emission:  A New Signal Transduction Mode of Pyrene Probes journal March 2001
Fluorescence Polarization for Monitoring Ribozyme Reactions in Real Time journal August 2000
Peptide Aptamers: Specific Inhibitors of Protein Function journal August 2004
Smart Nanomaterials Responsive to Multiple Chemical Stimuli with Controllable Cooperativity journal July 2006
RNA aptamers to the peptidyl transferase inhibitor chloramphenicol journal November 1997
An Effective Fluorescent Chemosensor for Mercury Ions journal July 2000
The hairpin ribozyme: structure, assembly and catalysis journal February 1998
DNAzyme amplification of molecular beacon signal journal September 2005
A DNA enzyme that cleaves RNA journal December 1994
Ion-Pair Extraction of Metalloporphyrins into Acetonitrile for Determination of Copper(II) journal January 1996
Lanthanide probes for a phosphodiester-cleaving, lead-dependent, DNAzyme journal January 1998
Turn-On and Ratiometric Mercury Sensing in Water with a Red-Emitting Probe journal May 2007
Characterization of a DNA-Cleaving deoxyribozyme journal October 2001
Adenine-Aptamer Complexes: A BIPARTITE RNA SITE THAT BINDS THE ADENINE NUCLEIC BASE journal November 2001
SURVEY AND SUMMARY: From DNA biosensors to gene chips journal August 2000
A general approach for the use of oligonucleotide effectors to regulate the catalysis of RNA-cleaving ribozymes and DNAzymes journal April 2002
A Highly Sensitive and Selective Catalytic DNA Biosensor for Lead Ions journal October 2000
Discrete dipole approximation for calculating extinction and Raman intensities for small particles with arbitrary shapes journal July 1995
Hemin-Stimulated Docking of Cytochrome c to a Hemin−DNA Aptamer Complex † journal April 2002
Structure-Switching Signaling Aptamers journal April 2003
A modular DNA signal translator for the controlled release of a protein by an aptamer journal March 2006
Wavelength-shifting molecular beacons journal November 2000
Fluorescent detection of zinc in biological systems: recent development on the design of chemosensors and biosensors journal January 2004
A Novel Potassium Sensing in Aqueous Media with a Synthetic Oligonucleotide Derivative. Fluorescence Resonance Energy Transfer Associated with Guanine Quartet−Potassium Ion Complex Formation journal December 2002
Selection of single-stranded DNA molecules that bind and inhibit human thrombin journal February 1992
A Luminescence-Based Mercury Biosensor journal February 1995
In vitro selection of RNA molecules that bind specific ligands journal August 1990
In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme journal January 2000
DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice. journal December 1996
DNA Aptamers Selected against the HIV-1 RNase H Display in Vitro Antiviral Activity † journal August 2001
H-DNA and Related Structures journal June 1994
A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA journal March 1993
Solvent extraction of lactic acid from aqueous solution journal January 1994
Folding DNA to create nanoscale shapes and patterns journal March 2006
Engineered allosteric ribozymes as biosensor components journal February 2002
Molecular-Level Control of Feature Separation in One-Dimensional Nanostructure Assemblies Formed by Biomolecular Nanolithography journal July 2004
An RNA motif that binds ATP journal August 1993
Solid phase extraction and spectrophotometric determination of mercury in tobacco and tobacco additives with 5-(p-aminobenzylidene)-thiothiorhodanine journal January 2006
Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication journal December 2005
Stem-loop oligonucleotides: a robust tool for molecular biology and biotechnology journal June 2002
Depleted and Natural Uranium: Chemistry and Toxicological Effects journal July 2004
Arginine-Binding RNAs Resembling TAR Identified by in Vitro Selection † journal January 1996
In Vitro Selection of Hg (II) and As (V)-Dependent RNA-Cleaving DNAzymes journal January 2007
Mercury II -Mediated Formation of Thymine−Hg II −Thymine Base Pairs in DNA Duplexes journal February 2006
Isolation of RNA Aptamers for Biological Cofactors by In Vitro Selection journal June 1994
Endogenous expression of a high-affinity pseudoknot RNA aptamer suppresses replication of HIV-1 journal September 2002
Isolation of a fluorophore-specific DNA aptamer with weak redox activity journal November 1998
Highly Dispersible Molecular Sieve Carbon Nanoparticles journal November 2004
MRI Detection of Thrombin with Aptamer Functionalized Superparamagnetic Iron Oxide Nanoparticles journal February 2008
Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA journal April 1984
Gold Mining as a Source of Mercury Exposure in the Brazilian Amazon journal May 1998
Molecular Aptamer for Real-Time Oncoprotein Platelet-Derived Growth Factor Monitoring by Fluorescence Anisotropy journal December 2001
Relaxometric and Magnetic Characterization of Ultrasmall Iron Oxide Nanoparticles with High Magnetization. Evaluation as Potential T 1 Magnetic Resonance Imaging Contrast Agents for Molecular Imaging journal April 2007
Proofreading and Error Removal in a Nanomaterial Assembly journal November 2005
The study of the gas—solid interaction of acetic acid with a cuprous oxide surface using reflection—absorption spectroscopy journal December 1974
Selected classes of minimised hammerhead ribozyme have very high cleavage rates at low Mg2+ concentration journal January 1999
Room-Temperature Single-Nucleotide Polymorphism and Multiallele DNA Detection Using Fluorescent Nanocrystals and Microarrays journal September 2003
Investigation of Fatty Acid Monolayers on Metals by Contact Potential Measurements 1 journal March 1965
Self-Cleaving Ribozymes of Hepatitis Delta Virus RNA journal August 1997
Colorimetric detection of DNA sequences based on electrostatic interactions with unmodified gold nanoparticles journal September 2004
Combination with liposome-entrapped, ends-modified raf antisense oligonucleotide (LErafAON) improves the anti-tumor efficacies of cisplatin, epirubicin, mitoxantrone, docetaxel and gemcitabine journal January 2004
A Bright and Specific Fluorescent Sensor for Mercury in Water, Cells, and Tissue journal September 2007
Environmental Copper: its Dynamics and Human Exposure Issues journal October 2001
Quantum dot–mediated biosensing assays for specific nucleic acid detection journal June 2005
Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc journal January 1996
DNA Aptamer Folding on Gold Nanoparticles:  From Colloid Chemistry to Biosensors journal March 2008
An Aptamer-Based Quartz Crystal Protein Biosensor journal September 2002
In vitro selection of molecular beacons journal October 2003
Selection and Characterization of an RNA Decoy for Transcription Factor NF-κB † journal March 1999
Automated synthesis of double dye-labeled oligonucleotides using tetramethylrhodamine (TAMRA) solid supports journal August 1997
Allosteric nucleic acid catalysts journal June 2000
In vitro selection, characterization, and application of deoxyribozymes that cleave RNA journal October 2005
New fluorescent and colorimetric DNAzyme biosensors for metal ions journal July 2003
A fast, simple and reliable method for the microdetermination of phosphorus in biological materials journal February 1964
Impact of Pollution Caused by Uranium Production on Soil Macrofauna journal January 2003
A DNA-based method for rationally assembling nanoparticles into macroscopic materials journal August 1996
2′-Fluoropyrimidine RNA-based Aptamers to the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF 165 ) : INHIBITION OF RECEPTOR BINDING AND VEGF-INDUCED VASCULAR PERMEABILITY THROUGH INTERACTIONS REQUIRING THE EXON 7-ENCODED DOMAIN journal August 1998
Reversible Switching of DNA-Gold Nanoparticle Aggregation journal December 2004
Structurally complex and highly active RNA ligases derived from random RNA sequences journal July 1995
Bioactive and nuclease-resistant L-DNA ligand of vasopressin journal October 1997
RNA catalysis journal December 1998
An Optical Fiber Chemical Sensor for Mercury Ions Based on a Porphyrin Dimer journal February 2002
Modeling active RNA structures using the intersection of conformational space: Application to the lead-activated ribozyme journal July 1998
A “Turn-On” Fluorescent Sensor for Selective Hg(II) Detection in Aqueous Media Based on Metal-Induced Dye Formation journal December 2006
MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles journal February 2003
Determination of lead in urine and whole blood by stable isotope dilution gas chromatography-mass spectrometry journal August 1994
In vitro selection of self-cleaving DNAs journal December 1996
Selection and design of high-affinity rna ligands for hiv-1 rev journal December 1993
Molecular Aptamer Beacons for Real-Time Protein Recognition journal March 2002
Hexaphyrin(1.0.1.0.0.0). A new colorimetric actinide sensor journal November 2004
Photodynamic Fluorescent Metal Ion Sensors with Parts per Billion Sensitivity journal April 1998
Equilibria in the Systems of the Higher Alcohols, Water and Salts. journal December 1915
Label-Free Electronic Detection of Thrombin in Blood Serum by Using an Aptamer-Based Sensor journal August 2005
Crystal structure of a four-stranded intercalated DNA: d(C4) journal November 1994
Viral-Induced Self-Assembly of Magnetic Nanoparticles Allows the Detection of Viral Particles in Biological Media
  • Perez, J. Manuel; Simeone, F. Joseph; Saeki, Yoshinaga
  • Journal of the American Chemical Society, Vol. 125, Issue 34, p. 10192-10193 https://doi.org/10.1021/ja036409g
journal August 2003
Sterically Stabilized Anti-HER2 Immunoliposomes:  Design and Targeting to Human Breast Cancer Cells in Vitro † journal January 1997
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase journal August 1990
Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy journal August 2005
Direct detection of antibody-antigen binding using an on-chip artificial pore journal January 2003
Programmed Assembly of DNA Functionalized Quantum Dots journal September 1999
Synthesis from DNA of a molecule with the connectivity of a cube journal April 1991
Engineering precision RNA molecular switches journal March 1999
Gadolinium-DTPA as a contrast agent in MRI: initial clinical experience in 20 patients journal August 1984
Calcium-dependent oligonucleotide antagonists specific for L-selectin. journal June 1996
A Colorimetric Lead Biosensor Using DNAzyme-Directed Assembly of Gold Nanoparticles journal June 2003
DNA aptamers and DNA enzymes journal June 1997
Redox Switchable Fluorescent Probe Selective for Either Hg(II) or Cd(II) and Zn(II) journal June 1999
What Controls the Melting Properties of DNA-Linked Gold Nanoparticle Assemblies? journal February 2003
Transferability of blood lead determinations by furnace atomic absorption spectrophotometry and continuum background correction journal October 1995
A specific quadrilateral synthesized from DNA branched junctions journal August 1989
Ordering of Quantum Dots Using Genetically Engineered Viruses journal May 2002
In vitro selection of hematoporphyrin binding DNA aptamers journal December 2000
A catalytic beacon sensor for uranium with parts-per-trillion sensitivity and millionfold selectivity journal February 2007
In vitro selection for altered divalent metal specificity in the RNase P RNA journal December 1997
Emerging concepts in molecular MRI journal February 2007
A Selective and Sensitive Fluoroionophore for Hg II , Ag I , and Cu II with Virtually Decoupled Fluorophore and Receptor Units journal February 2000
Optical sensor for the visual detection of mercury using mesoporous silica anchoring porphyrin moiety journal January 2005
Uranyl Acetate Causes DNA Single Strand Breaks In Vitro in the Presence of Ascorbate (Vitamin C) journal April 2003
Targeting of ultrasmall superparamagnetic iron oxide (USPIO) particles to tumor cellsin Vivo by using transferrin receptor pathways journal August 1998
Unmodified gold nanoparticles as a colorimetric probe for potassium DNA aptamers journal January 2006
Smart single-chip gas sensor microsystem journal November 2001
Macrophage Imaging in Central Nervous System and in Carotid Atherosclerotic Plaque Using Ultrasmall Superparamagnetic Iron Oxide in Magnetic Resonance Imaging journal January 2004
MATERIALS SCIENCE: Nucleic Acid Nanotechnology journal December 2004
Accumulation of Ultrasmall Superparamagnetic Particles of Iron Oxide in Human Atherosclerotic Plaques Can Be Detected by In Vivo Magnetic Resonance Imaging journal May 2003
The risk of lead toxicity in homes with lead paint hazard journal February 1991
Crystal Structure of the Leadzyme at 1.8 Å Resolution:  Metal Ion Binding and the Implications for Catalytic Mechanism and Allo Site Ion Regulation † journal August 2003
Determination of the orientation of aromatic molecules adsorbed on platinum electrodes: the influence of iodide, a surface-active anion journal May 1982
Catalytic Signal Amplification Using a Heck Reaction. An Example in the Fluorescence Sensing of Cu(II) journal November 2004
Adaptive Recognition by Nucleic Acid Aptamers journal February 2000
Preparation and Characterization of Au Colloid Monolayers journal February 1995
Determination of the orientation of adsorbed molecules at solid-liquid interfaces by thin-layer electrochemistry: aromatic compounds at platinum electrodes journal May 1982
Detection of small organic analytes by fluorescing molecular switches journal October 2001
DNA in a material world journal January 2003
A Calcium-Sensitive Magnetic Resonance Imaging Contrast Agent journal February 1999
A Highly Selective and Sensitive Fluorescent Chemosensor for Hg 2+ in Neutral Buffer Aqueous Solution journal March 2004
Electrothermal isotope dilution inductively coupled plasma mass spectrometry method for the determination of sub-ng ml –1 levels of lead in human plasma journal January 1994
Phosphorylating DNA with DNA journal March 1999
The covalent attachment of multiple fluorophores to DNA containing phosphorothioate diesters results in highly sensitive detection of single-stranded DNA journal November 1991
Gold nanoparticlebased optical probes for target-responsive DNA structures journal March 2008
Directed Evolution of Nucleic Acid Enzymes journal June 2004
Therapeutic opportunities for targeted liposomal drug delivery journal September 1996
Optical fibre reflectance sensors for the detection of heavy metal ions based on immobilised Br-PADAP journal August 1998
The effects of iron oxides on proton relaxivity journal November 1988
Extraction of acetonitrile from aqueous solutions. 1. Ternary liquid equilibriums journal January 1978
An Autonomous DNA Nanomotor Powered by a DNA Enzyme journal July 2004
Pseudohexagonal 2D DNA Crystals from Double Crossover Cohesion journal August 2004
Determination of trace concentrations of lead and nickel in human milk by electrothermal atomisation atomic absorption spectrophotometry and inductively-coupled plasma emission spectroscopy journal February 1982
Alloy Formation of Gold−Silver Nanoparticles and the Dependence of the Plasmon Absorption on Their Composition journal May 1999
Tumor targeting using anti-her2 immunoliposomes journal July 2001
Immobilized RNA switches for the analysis of complex chemical and biological mixtures journal April 2001
Selection of RNA Aptamers That Are Specific and High-Affinity Ligands of the Hepatitis C Virus RNA-Dependent RNA Polymerase journal April 2002
Differential Gene Expression Patterns in HER2/neu-Positive and -Negative Breast Cancer Cell Lines and Tissues journal October 2002
Engineering DNA aptamers and DNA enzymes with fluorescence-signaling properties journal January 2004
Pharmacokinetics and biodistribution of the camptothecin–polymer conjugate IT-101 in rats and tumor-bearing mice journal August 2005
Noninvasive Detection of Clinically Occult Lymph-Node Metastases in Prostate Cancer journal June 2003
DNA ligands that bind tightly and selectively to cellobiose journal May 1998
Aptamer-Based Colorimetric Probe for Cocaine journal August 2002
Fluorescent peptide sensor for the selective detection of Cu2+ journal March 2007
Self-Assembled Monolayers of Thiol-End-Labeled DNA at Mercury Electrodes journal July 2006
A two-channel molecular dosimeter for the optical detection of copper( ii ) journal January 2003
Synthesis of Linear, β-Cyclodextrin-Based Polymers and Their Camptothecin Conjugates journal September 2003
Group I Ribozymes: Substrate Recognition, Catalytic Strategies, and Comparative Mechanistic Analysis book January 1996
Sterically stabilized liposomes. Reduction in electrophoretic mobility but not electrostatic surface potential journal April 1992
Design and self-assembly of two-dimensional DNA crystals journal August 1998
Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures journal February 1992
Smart “Turn-on” Magnetic Resonance Contrast Agents Based on Aptamer-Functionalized Superparamagnetic Iron Oxide Nanoparticles journal September 2007
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena journal November 1982
Oligonucleotide immobilization on micropatterned streptavidin surfaces journal April 2000
The influence of the blood levels of lead, aluminum and vanadium upon the arterial hypertension journal January 1995
Light-directed, spatially addressable parallel chemical synthesis journal February 1991
Mercury: major issues in environmental health. journal April 1993
Determination of Lead in Blood by Square Wave Anodic Stripping Voltammetry at a Carbon Disk Ultramicroelectrode journal July 1994
RNA aptamers that bind L-arginine with sub-micromolar dissociation constants and high enantioselectivity journal March 1996
Two Decades of RNA Catalysis journal September 2002
A DNA metalloenzyme with DNA ligase activity journal June 1995
Peptide platforms for metal ion sensing conference December 1999
Combinatorial methods: aptamers and aptazymes conference December 1999
RNA-catalysed RNA polymerization using nucleoside triphosphates journal July 1996
Photoactive chemosensors 4: a Cu2+ protein cavity mimicking fluorescent chemosensor for selective Cu2+ recognition journal June 2004
A Reagentless Signal-On Architecture for Electronic, Aptamer-Based Sensors via Target-Induced Strand Displacement journal December 2005
Efficient signaling platforms built from a small catalytic DNA and doubly labeled fluorogenic substrates journal December 2006
A Selective, Ratiometric Fluorescent Sensor for Pb 2+ journal January 2000
Using molecular beacons as a sensitive fluorescence assay for enzymatic cleavage of single-stranded DNA journal June 2000
Defining a Smaller RNA Substrate for Elongation Factor Tu journal February 1995
Simple and sensitive aptamer-based colorimetric sensing of protein using unmodified gold nanoparticle probes journal January 2007
The Chemical Form of Mercury in Fish journal August 2003
Review: Environmental exposure to mercury and its toxicopathologic implications for public health journal January 2003
Approaching The Limit: Can One DNA Oligonucleotide Assemble into Large Nanostructures? journal March 2006
Stripping voltammetric determination of trace levels of uranium by synergic adsorption journal January 1989
In vitro evolution of randomized ribozymes book January 1996
Assembly and characterization of five-arm and six-arm DNA branched junctions journal June 1991
A review of metal accumulation and toxicity in wild mammals journal June 1986
DNA Aptamers Selected Against the HIV-1 trans -Activation-responsive RNA Element Form RNA-DNA Kissing Complexes journal April 1999
Equilibria in Systems containing Alcohol, Salts and Water, including a New Method of Alcohol Analysis journal May 1913
Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics journal September 1999
Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology journal January 2001
Sequence-Encoded Self-Assembly of Multiple-Nanocomponent Arrays by 2D DNA Scaffolding journal December 2005
Evidence for the metal-cofactor independence of an RNA phosphodiester-cleaving DNA enzyme journal August 1997
Dinucleotide Junction Cleavage Versatility of 8-17 Deoxyribozyme journal January 2004
Photoactive chemosensors 3 : a unique case of fluorescence enhancement with Cu( ii ) journal January 2002
Capillary Optode: Determination of Mercury(II) in Aqueous Solution journal January 1999
Peptide bond formation by in vitro selected ribozymes journal November 1997
BIOCHEMISTRY: Biosensors-Sense and Sensitivity journal November 2000
DNA Triangles and Self-Assembled Hexagonal Tilings journal November 2004
Ribozyme-catalysed amino-acid transfer reactions journal May 1996
In Vitro Selection of Functional Nucleic Acids journal June 1999
Programmed Materials Synthesis with DNA journal July 1999
A Lead-Dependent DNAzyme with a Two-Step Mechanism † journal June 2003
High-Throughput-Compatible Assay for glmS Riboswitch Metabolite Dependence journal February 2006
Electrothermal atomic absorption spectrometric determination of Al, Cu, Fe, Pb, V and Zn in clinical samples and in certified environmental reference materials journal September 1994
Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells journal November 1999
Inhibition of receptor binding by high-affinity RNA ligands to vascular endothelial growth factor journal August 1994
DNA-Modified Core−Shell Ag/Au Nanoparticles journal August 2001
Graphite furnace atomic absorption spectroscopic measurement of blood lead in matrix-matched standards journal September 1994
Antibody-based sensors for heavy metal ions journal December 2001
Aptamer-Based Folding Fluorescent Sensor for Cocaine journal May 2001
A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate journal January 1998
Structural diversity of self-cleaving ribozymes journal May 2000
Deoxyribozymes: New players in the ancient game of biocatalysis journal June 1999
Selective extraction of gold(III) in the presence of Pd(II) and Pt(IV) by salting-out of the mixture of 2-propanol and water journal November 2002
Interaction of retroviral nucleocapsid proteins with transfer RNAPhe: a lead ribozyme and 1H NMR study journal September 1996
Fluorescent Sensors for Zn 2+ Based on a Fluorescein Platform:  Synthesis, Properties and Intracellular Distribution journal August 2001
Synthesis and characterization of DNA with ferrocenyl groups attached to their 5′-termini: electrochemical characterization of a redox-active nucleotide monolayer journal January 1996
At the Crossroads of Chemistry, Biology, and Materials journal December 2003
Potent 2'-Amino-2'-deoxypyrimidine RNA Inhibitors of Basic Fibroblast Growth Factor journal September 1995
Magnetic Sensors for Protease Assays journal March 2003
Highly Selective and Sensitive Phosphane Sulfide Derivative for the Detection of Hg 2+ in an Organoaqueous Medium journal March 2007
A Combinatorial Approach To Discover New Chelators for Optical Metal Ion Sensing journal November 2000
Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase journal September 1998
A New Fluorescent Chemosensor for Copper Ions Based on Tripeptide Glycyl−Histidyl−Lysine (GHK) journal October 2001
A novel RNA motif for neomycin recognition journal August 1995
Interference-based detection of nucleic acid targets on optically coated silicon journal January 2001
Programmable self-assembly of metal ions inside artificial DNA duplexes journal November 2006
In vitro selection of RNA aptamers specific for cyanocobalamin journal February 1994
Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution. journal April 1993
Expanding the scope of RNA catalysis journal June 1994
DNA aptamers that bind to chitin journal March 2000
Colorimetric Cu2+ detection with a ligation DNAzyme and nanoparticles journal January 2007
Mercury Detection in Seawater Using a Mercaptoacetic Acid Modified Gold Microwire Electrode journal May 2005
A DNAzyme Catalytic Beacon Sensor for Paramagnetic Cu 2+ Ions in Aqueous Solution with High Sensitivity and Selectivity journal August 2007
Determination of Picomolar Concentrations of Metal Ions Using Fluorescence Anisotropy:  Biosensing with a “Reagentless” Enzyme Transducer journal November 1998
A colorimetric sensor array for odour visualization journal August 2000
Label-Free Electrochemical Detection for Aptamer-Based Array Electrodes journal August 2005
Design of allosteric hammerhead ribozymes activated by ligand-induced structure stabilization journal July 1999

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