skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Fermentation process using specific oxygen uptake rates as a process control

Patent ·
OSTI ID:1021878
 [1];  [2];  [3]
  1. Minnetonka, MN
  2. Maple Grove, MN
  3. Minneapolis, MN
+ Show Author Affiliations

Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.

Research Organization:
Cargill Inc. (Wayzata, MN)
Sponsoring Organization:
USDOE
DOE Contract Number:
FC36-00GO10598
Assignee:
Cargill Inc. (Wayzata, MN)
Patent Number(s):
7,939,298
Application Number:
11/707,188
OSTI ID:
1021878
Country of Publication:
United States
Language:
English

References (5)

Replacement of a Metabolic Pathway for Large-Scale Production of Lactic Acid from Engineered Yeasts journal September 1999
Efficient Homolactic Fermentation by Kluyveromyces lactis Strains Defective in Pyruvate Utilization and Transformed with the Heterologous LDH Gene journal December 2001
Development of metabolically engineered Saccharomyces cerevisiae cells for the production of lactic acid journal May 1995
Effect of benzoic acid on metabolic fluxes in yeasts: A continuous-culture study on the regulation of respiration and alcoholic fermentation journal July 1992
Large scale production of cyclohexanone monooxygenase from Escherichia coli TOP10 pQR239 journal February 2001

Similar Records

Related Subjects

60 APPLIED LIFE SCIENCES