Genetically encoded fluorescent coumarin amino acids
Patent
·
OSTI ID:1017438
- San Diego, CA
- La Jolla, CA
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.
- Research Organization:
- The Scripps Research Inst., La Jolla, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-03ER46051
- Assignee:
- The Scripps Research Institute (La Jolla, CA)
- Patent Number(s):
- 7,807,411
- Application Number:
- 11/805,247
- OSTI ID:
- 1017438
- Country of Publication:
- United States
- Language:
- English
Similar Records
Genetically encoded fluorescent coumarin amino acids
Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
Patent
·
Tue Jun 05 00:00:00 EDT 2012
·
OSTI ID:1017438
Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
Patent
·
Tue Jul 10 00:00:00 EDT 2012
·
OSTI ID:1017438
Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
Patent
·
Tue Sep 07 00:00:00 EDT 2010
·
OSTI ID:1017438