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Title: INEL BNCT Research Program annual report, 1992

Abstract

This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT ismore » presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database.« less

Authors:
 [1]
  1. ed.
Publication Date:
Research Org.:
EG and G Idaho, Inc., Idaho Falls, ID (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
10172901
Report Number(s):
EGG-2700
ON: DE93016574; TRN: 93:017837
DOE Contract Number:  
AC07-76ID01570
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: May 1993
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NEUTRON CAPTURE THERAPY; RESEARCH PROGRAMS; PROGRESS REPORT; BORON 10; RADIOPHARMACEUTICALS; ORGANIC BORON COMPOUNDS; LIPOSOMES; CHEMICAL PREPARATION; LIPOPROTEINS; LABELLING; EXPERIMENTAL NEOPLASMS; DOGS; LEADING ABSTRACT; 550603; 550604; EXTERNAL RADIATION IN THERAPY; UNSEALED RADIONUCLIDES IN THERAPY

Citation Formats

Venhuizen, J R. INEL BNCT Research Program annual report, 1992. United States: N. p., 1993. Web. doi:10.2172/10172901.
Venhuizen, J R. INEL BNCT Research Program annual report, 1992. United States. https://doi.org/10.2172/10172901
Venhuizen, J R. 1993. "INEL BNCT Research Program annual report, 1992". United States. https://doi.org/10.2172/10172901. https://www.osti.gov/servlets/purl/10172901.
@article{osti_10172901,
title = {INEL BNCT Research Program annual report, 1992},
author = {Venhuizen, J R},
abstractNote = {This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT is presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database.},
doi = {10.2172/10172901},
url = {https://www.osti.gov/biblio/10172901}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat May 01 00:00:00 EDT 1993},
month = {Sat May 01 00:00:00 EDT 1993}
}