SERS molecular probe for diagnostics and therapy and methods of use thereof

Patent · Sun May 31 00:00:00 EST 11

OSTI ID:1016828

Vo-Dinh, Tuan ^[1]

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1. Knoxville, TN

An oligonucleotide-based SERS molecular probe (SMP) includes a nanoparticle having at least a metal component, and at least one pin loop, the pin loop including a loop sequence complementary to at least one target sequence, a first stem attached to one end of the loop sequence, a second stem attached to the other end of the loop sequence, and at least one SERS active label attached to the first stem. The nanoparticle is attached to the second stem. The probe generates a stronger SERS signal upon irradiation with excitation radiation when not bound to the target sequence as compared to the SERS signal generated following hybridization of the probe with the target sequence.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-00OR22725
• Assignee: U-T Battelle, LLC (Oak Ridge, TN)
• Patent Number(s): 7951535
• Application Number: 11/972,110
• OSTI ID: 1016828
• Resource Relation: Patent File Date: 2008 Jan 10
• Country of Publication: United States
• Language: English