The development of in vitro mutagenicity testing systems using T-lymphocytes. Research progress report, November 1, 1989--April 30, 1992

Technical Report · Fri May 01 00:00:00 EDT 1992

DOI:https://doi.org/10.2172/10154144· OSTI ID:10154144

Albertini, R J

This work has focused on the development of in vitro T-cell mutation assays. Conditions have been defined to measure the in vitro induction of mutations at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus in human T-lymphocytes. This assay is a parallel to our in vivo hprt assay, in that the same cells are utilized. However, the in vitro assay allows for carefully controlled dose response studies. 21 refs., 16 figs., 13 tabs.

• Research Organization: Vermont Univ., Burlington, VT (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-87ER60502
• OSTI ID: 10154144
• Report Number(s): DOE/ER/60502-6; ON: DE92015918
• Resource Relation: Other Information: PBD: May 1992
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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BIOASSAY
DESIGN
HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE
GENE MUTATIONS
LYMPHOCYTES
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BIOLOGICAL RADIATION EFFECTS
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IODINE 131
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560300
560120
560161
CHEMICALS METABOLISM AND TOXICOLOGY
RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE
MAN