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Title: Biocatalytic material comprising multilayer enzyme coated fiber

Patent ·
OSTI ID:1015175
 [1];  [1];  [2]
  1. Richland, WA
  2. West Richland, WA
+ Show Author Affiliations

The present invention relates generally to high stability, high activity biocatalytic materials and processes for using the same. The materials comprise enzyme aggregate coatings having high biocatalytic activity and stability useful in heterogeneous environment. These new materials provide a new biocatalytic immobilized enzyme system with applications in bioconversion, bioremediation, biosensors, and biofuel cells.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RLO1830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
7,611,878
Application Number:
US Patent Application 11/251,540
OSTI ID:
1015175
Country of Publication:
United States
Language:
English

References (20)

Preparation of biocatalytic nanofibres with high activity and stability via enzyme aggregate coating on polymer nanofibres journal April 2005
Cross-linked aggregates of penicillin acylase: robust catalysts for the synthesis of β-lactam antibiotics journal January 2001
Enzyme-Carrying Polymeric Nanofibers Prepared via Electrospinning for Use as Unique Biocatalysts journal October 2002
Stabilisation of oxygen-labile nitrilases via co-aggregation with poly(ethyleneimine) journal March 2006
Direct fabrication of enzyme-carrying polymer nanofibers by electrospinning journal January 2005
Immobilized Hydroxynitrile Lyases for Enantioselective Synthesis of Cyanohydrins: Sol-Gels and Cross-Linked Enzyme Aggregates journal August 2006
Penicillin Acylase Catalysed Synthesis of Ampicillin in Hydrophilic Organic Solvents journal June 2003
Miniature Biofuel Cells with Improved Stability Under Continuous Operation journal October 2006
Continuous kinetic resolution catalysed by cross-linked enzyme aggregates, ‘CLEAs’, in supercritical CO 2 journal January 2006
Cross-linked enzyme aggregates (CLEAs): A novel and versatile method for enzyme immobilization (a review) journal January 2005
A new, mild cross-linking methodology to prepare cross-linked enzyme aggregates journal January 2004
Electrospinning of Polymeric and Ceramic Nanofibers as Uniaxially Aligned Arrays journal August 2003
Crude aminoacylase fromaspergillus sp. is a mixture of hydrolases journal October 2003
Synthesis of enantiomerically pure (S)-mandelic acid using an oxynitrilase–nitrilase bienzymatic cascade: a nitrilase surprisingly shows nitrile hydratase activity journal February 2006
Immobilised enzymes: carrier-bound or carrier-free? journal August 2003
Preparation, optimization, and structures of cross-linked enzyme aggregates (CLEAs) journal January 2004
Cross-Linked Aggregates of ( R )-Oxynitrilase:  A Stable, Recyclable Biocatalyst for Enantioselective Hydrocyanation journal January 2005
MATERIAL SCIENCE: Spinning Continuous Fibers for Nanotechnology journal June 2004
Cross-Linked Enzyme Aggregates:  A Simple and Effective Method for the Immobilization of Penicillin Acylase journal May 2000
Cross-Linked Aggregates of the Hydroxynitrile Lyase fromManihot esculenta: Highly Active and Robust Biocatalysts journal August 2006

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES