Cell specific radiation dosimetry in skeleton from life-span carcinogenesis studies. Final report

Technical Report · Mon Apr 05 00:00:00 EDT 1993

DOI:https://doi.org/10.2172/10140091· OSTI ID:10140091

Webster, S S.J.

The osteogenic sarcoma is the dominant life-threatening pathology in lifespan studies of beagles exposed to alpha-emitting bone-seeking radionuclides. It was deduced from these studies that certain skeletal sites are more prone to develop tumors. This project sought to determine the bone cells at risk and their cell-specific radiation dose. The cell-specific radiation dose values are related to loss and high Ra-226 and Pu-239 induced osteogenic sarcoma sites, to test different dose response hypothesis and predict the extent of effects in humans.

• Research Organization: Utah Univ., Salt Lake City, UT (United States). Radiobiology Div.
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-89ER60764
• OSTI ID: 10140091
• Report Number(s): DOE/ER/60764-T1; ON: DE93011620
• Resource Relation: Other Information: PBD: 5 Apr 1993
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PLUTONIUM 239
TISSUE DISTRIBUTION
RADIUM 226
BONE CELLS
RADIATION DOSES
PROGRESS REPORT
DOSIMETRY
LIFE SPAN
BONE TISSUES
RATS
DOGS
VERTEBRAE
TRITIUM COMPOUNDS
TRACER TECHNIQUES
560161
560120
MAN
RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE