Environmental genotoxicity: Probing the underlying mechanisms

Conference · Fri Dec 31 00:00:00 EST 1993

OSTI ID:10128851

Shugart, L ^[1]; Theodorakis, C ^[2]

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1. Oak Ridge National Lab., TN (United States)
2. Tennessee Univ., Knoxville, TN (United States)

Environmental pollution is a complex issue because of the diversity of anthropogenic agents, both chemical and physical, that have been detected and catalogued. The consequences to biota from exposure to genotoxic agents present an additional problem because of the potential for these agents to produce adverse change at the cellular and organismal levels. Past studies in genetic toxicology at the Oak Ridge National Laboratory have focused on structural damage to the DNA of environmental species that may occur after exposure to genotoxic agents and the use of this information to document exposure and to monitor remediation. In an effort to predict effects at the population, community and ecosystem levels, current studies in genetic ecotoxicology are attempting to characterize the biological mechanisms at the gene level that regulate and limit the response of an individual organism to genotoxic factors in their environment.

• Research Organization: Oak Ridge National Lab., TN (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 10128851
• Report Number(s): CONF-9310289-1; ON: DE94007413
• Resource Relation: Conference: NAPA conference on genetic and molecular ecotoxicology,Berkeley, CA (United States),12-15 Oct 1993; Other Information: PBD: [1993]
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS
WATER POLLUTION
ENVIRONMENTAL EFFECTS
POLLUTANTS
GENETIC EFFECTS
ANIMALS
BIOLOGICAL ADAPTATION
CETACEANS
DNA ADDUCTS
PLANTS
ULTRAVIOLET RADIATION
LOW-LEVEL RADIOACTIVE WASTES
STRAND BREAKS
GENE MUTATIONS
FISHES
TURTLES
BIOLOGICAL RADIATION EFFECTS
560120
054000
560300
RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE
HEALTH AND SAFETY
CHEMICALS METABOLISM AND TOXICOLOGY