Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17

Gray, Joe W; Pinkel, Daniel; Kallioniemi, Olli-Pekka; Kallioniemi, Anne; Sakamoto, Masaru

Title: Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17

Patent · Tue Oct 06 00:00:00 EDT 2009

OSTI ID:1001988

Gray, Joe W ^[1]; Pinkel, Daniel ^[2]; Kallioniemi, Olli-Pekka ^[3]; Kallioniemi, Anne ^[4]; Sakamoto, Masaru ^[5]

San Francisco, CA
Lafayette, CA
Turku, FI
Tampere, FI
Tokyo, JP

Methods and compositions for staining based upon nucleic acid sequence that employ .[.nudeic.]. .Iadd.nucleic .Iaddend.acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-48

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: RE40,929

OSTI ID:: 1001988

Country of Publication:: United States

Language:: English

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