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Title: Labeled Cocaine Analogs

Abstract

Novel methods for positron emission tomography or single photon emission spectroscopy using tracer compounds having the structure: ##STR1## where X in .beta. configuration is phenyl, naphthyl; 2,3 or 4-iodophenyl; 2,3 or 4-(trimethylsilyl)phenyl; 3,4,5 or 6-iodonaphthyl; 3,4,5 or 6-(trimethylsilyl)naphthyl; 2,3 or 4-(trialkylstannyl)phenyl; or 3,4,5 or 6-(trialkylstannyl)napthyl Y in .beta. configuration is 2-fluoroethoxy, 3-fluoropropoxy, 4-fluorobutoxy, 2-fluorocyclopropoxy, 2 or 3-fluorocyclobutoxy, R,S 1'-fluoroisopropoxy, R 1'-fluoroisopropoxy, S 1'-fluoroisopropoxy, 1',3'-difluoroisopropoxy, R,S 1'-fluoroisobutoxy, R 1'-fluoroisobutoxy, S 1'-fluoroisobutoxy, R,S 4'-fluoroisobutoxy, R 4'-fluoroisobutoxy, S 4'-fluoroisobutoxy, or 1',1'-di(fluoromethyl)isobutoxy, The compounds bind dopamine transporter protein and can be labeled with .sup.18 F or .sup.123 I for imaging.

Inventors:
 [1];  [2];  [1]
  1. Atlanta, GA
  2. Tucker, GA
Publication Date:
Research Org.:
Emory University (Atlanta, GA)
OSTI Identifier:
879462
Patent Number(s):
US 5,888,475
Application Number:
08/948791
Assignee:
Emory University (Atlanta, GA)
DOE Contract Number:  
FG05-93ER61737
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Goodman, Mark M, Shi, Bing Zhi, and Keil, Robert N. Labeled Cocaine Analogs. United States: N. p., 1999. Web.
Goodman, Mark M, Shi, Bing Zhi, & Keil, Robert N. Labeled Cocaine Analogs. United States.
Goodman, Mark M, Shi, Bing Zhi, and Keil, Robert N. 1999. "Labeled Cocaine Analogs". United States. https://www.osti.gov/servlets/purl/879462.
@article{osti_879462,
title = {Labeled Cocaine Analogs},
author = {Goodman, Mark M and Shi, Bing Zhi and Keil, Robert N},
abstractNote = {Novel methods for positron emission tomography or single photon emission spectroscopy using tracer compounds having the structure: ##STR1## where X in .beta. configuration is phenyl, naphthyl; 2,3 or 4-iodophenyl; 2,3 or 4-(trimethylsilyl)phenyl; 3,4,5 or 6-iodonaphthyl; 3,4,5 or 6-(trimethylsilyl)naphthyl; 2,3 or 4-(trialkylstannyl)phenyl; or 3,4,5 or 6-(trialkylstannyl)napthyl Y in .beta. configuration is 2-fluoroethoxy, 3-fluoropropoxy, 4-fluorobutoxy, 2-fluorocyclopropoxy, 2 or 3-fluorocyclobutoxy, R,S 1'-fluoroisopropoxy, R 1'-fluoroisopropoxy, S 1'-fluoroisopropoxy, 1',3'-difluoroisopropoxy, R,S 1'-fluoroisobutoxy, R 1'-fluoroisobutoxy, S 1'-fluoroisobutoxy, R,S 4'-fluoroisobutoxy, R 4'-fluoroisobutoxy, S 4'-fluoroisobutoxy, or 1',1'-di(fluoromethyl)isobutoxy, The compounds bind dopamine transporter protein and can be labeled with .sup.18 F or .sup.123 I for imaging.},
doi = {},
url = {https://www.osti.gov/biblio/879462}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 30 00:00:00 EST 1999},
month = {Tue Mar 30 00:00:00 EST 1999}
}

Works referenced in this record:

Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428)
journal, February 1993


Synthesis and receptor binding of N-substituted tropane derivatives. High-affinity ligands for the cocaine receptor
journal, May 1991


Positron emission tomography after MPTP: observations relating to the cause of Parkinson's disease
journal, September 1985


Compounds Affecting the Central Nervous System. 4. 3.beta.-Phenyltropane-2-carboxylic Esters and Analogs
journal, November 1973


N-Modified fluorophenyltropane analogs of cocaine with high affinity for cocaine receptors
journal, April 1990