Effect of LET and microdistribution of radiation on the transformation in vitro and in vivo. Comprehensive progress report
Work has involved the following three areas: (1) an investigation of the mechanisms of radiation carcinogenesis by studying the events involved in the process of malignant transformation of mouse 10 T-1/2 cells; (2) an investigation of the effects of promoting agents on radiation-induced transformation in vitro; and (3) an investigation of the induction of transformation by internally emitting radionuclides incorporated into cellular DNA. The latter area has been extended to include studies of mutagenesis by these radionuclides in human lymphoblasts, and molecular measurements of DNA strand breaks. During the past year, research has focused on the first area, as well as on studies of the mutagenic effects of incorporated radionuclides.
- Research Organization:
- Harvard Univ., Boston, MA (USA). School of Public Health
- DOE Contract Number:
- AC02-77EV04322
- OSTI ID:
- 5895948
- Report Number(s):
- DOE/EV/04322-T2; ON: DE83017429
- Country of Publication:
- United States
- Language:
- English
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Mechanisms and secondary factors involved in the induction of radiation transformation in vitro
(Mechanisms and secondary factors involved in the induction of radiation transformation in vitro): Comprehensive progress report
Related Subjects
ANIMAL CELLS
ONCOGENIC TRANSFORMATIONS
CARCINOGENESIS
RADIOINDUCTION
TUMOR PROMOTERS
RADIOSENSITIVITY EFFECTS
BIOLOGICAL EFFECTS
CELL CULTURES
IN VITRO
INTERNAL IRRADIATION
IODINE 125
MICE
MUTAGENESIS
STRAND BREAKS
ANIMALS
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IRRADIATION
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
PATHOGENESIS
PROMOTERS
RADIOISOTOPES
RODENTS
VERTEBRATES
560122* - Radiation Effects on Cells- Internal Source- (-1987)
560301 - Chemicals Metabolism & Toxicology- Cells- (-1987)