Electromagnetic field effects on cells of the immune system: The role of calcium signalling
During the past decade considerable evidence has accumulated demonstrating the exposures of cells of the immune system to relatively weak extremely-low-frequency (ELF) electromagnetic fields (< 300 Hz) can elicit cellular changes which might be relevant to in-vivo immune activity. However, knowledge about the underlying biological mechanisms by which weak fields induce cellular changes is still very limited. It is generally believed that the cell membrane and Ca{sup 2+} regulated activity is involved in bioactive ELF field-coupling to living systems. This article begins with a short review of the current state of knowledge concerning the effects of nonthermal levels of ELF electromagnetic fields on the biochemistry and activity of immune cells, and then closely examines new results which suggest a role for Ca{sup 2+} in the induction of these cellular field effects. Based on these findings it is proposed that membrane-mediated Ca{sup 2+} signalling processes are involved in the mediation of field effects on the immune system. 64 refs., 2 tabs.
- Research Organization:
- Lawrence Berkeley Lab., CA (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 5261345
- Report Number(s):
- LBL-31097; CONF-9104107-1; ON: DE92000852
- Resource Relation:
- Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991
- Country of Publication:
- United States
- Language:
- English
Similar Records
Model for external influences on cellular signal transduction pathways including cytosolic calcium oscillations
Intracellular calcium during signal transduction in the lymphocyte is altered by ELF magnetic and electric fields
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL PATHWAYS
CALCIUM
MEMBRANE TRANSPORT
ELECTROMAGNETIC FIELDS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOPHYSICS
CALCIUM 45
CELL TRANSFORMATIONS
DNA REPLICATION
EPIDEMIOLOGY
LEUKOCYTES
MICROWAVE RADIATION
RADIOWAVE RADIATION
RECEPTORS
REVIEWS
TRACER TECHNIQUES
TRANSCRIPTION
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CALCIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DOCUMENT TYPES
ELECTROMAGNETIC RADIATION
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MEMBRANE PROTEINS
METALS
NUCLEI
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
PROTEINS
RADIATIONS
RADIOISOTOPES
560400* - Other Environmental Pollutant Effects
550300 - Cytology
551000 - Physiological Systems