Operation of the “Small” BioAMS spectrometers at CAMS: Past and future prospects

Ognibene, T. J.; Haack, K. W.; Bench, G.; Brown, T. A.; Turteltaub, K. W.

doi:10.1016/j.nimb.2015.05.019

Title: Operation of the “Small” BioAMS spectrometers at CAMS: Past and future prospects

Journal Article · Tue May 26 00:00:00 EDT 2015 · Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms

DOI:https://doi.org/10.1016/j.nimb.2015.05.019· OSTI ID:1376007

Ognibene, T. J. ^[1]; Haack, K. W. ^[1]; Bench, G. ^[1]; Brown, T. A. ^[1]; Turteltaub, K. W. ^[2]

Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Center for Accelerator Mass Spectrometry
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Biology and Biotechnology Division

A summary of results from the solid samples run on our compact 1 MV AMS system over its 13.5 years of operation is presented. On average 7065 samples per year were measured with that average dropping to 3278 samples per year following the deployment of our liquid sample capability. Although the dynamic range of our spectrometer is 4.5 orders in magnitude, most of the measured graphitic samples had ¹⁴C/C concentrations between 0.1 and 1 modern. Furthermore, the measurements of our ANU sucrose standard followed a Gaussian distribution with an average of 1.5082 ± 0.0134 modern. The LLNL biomedical AMS program supported many different types of experiments, however, the large majority of samples measured were derived from animal model systems. We have transitioned all of our biomedical AMS measurements to the recently installed 250 kV SSAMS instrument with good agreement compared in measured 14C/C isotopic ratios between sample splits. We then present results from replacement of argon stripping gas with helium in the SSAMS with a 22% improvement in ion transmission through the accelerator and high-energy analyzing magnet.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1376007

Alternate ID(s):: OSTI ID: 1246212

Report Number(s):: LLNL-JRNL-664218; PII: S0168583X15004905; TRN: US1702564

Journal Information:: Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms, Vol. 361, Issue C; ISSN 0168-583X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 6 works

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References (10)

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Cited By (2)

Human ADME for YH12852 using wavelength scanning cavity ring-down spectroscopy (WS-CRDS) after a low radioactivity dose Kim, Anhye; Dueker, Stephen R.; Dong, Feng Bioanalysis, Vol. 12, Issue 2 https://doi.org/10.4155/bio-2019-0119	journal	January 2020
Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry Hum, Nicholas R.; Martin, Kelly A.; Malfatti, Michael A. Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-33368-0	journal	October 2018

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