Multiscale spectral nanoscopy

Yang, Haw; Welsher, Kevin

Title: Multiscale spectral nanoscopy

Patent · Tue Nov 15 00:00:00 EST 2016

OSTI ID:1332117

Yang, Haw; Welsher, Kevin

A system and method for non-invasively tracking a particle in a sample is disclosed. The system includes a 2-photon or confocal laser scanning microscope (LSM) and a particle-holding device coupled to a stage with X-Y and Z position control. The system also includes a tracking module having a tracking excitation laser, X-Y and Z radiation-gathering components configured to detect deviations of the particle in an X-Y and Z directions. The system also includes a processor coupled to the X-Y and Z radiation gathering components, generate control signals configured to drive the stage X-Y and Z position controls to track the movement of the particle. The system may also include a synchronization module configured to generate LSM pixels stamped with stage position and a processing module configured to generate a 3D image showing the 3D trajectory of a particle using the LSM pixels stamped with stage position.

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Research Organization:: Princeton Univ., NJ (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: SC0006838

Assignee:: THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, NJ)

Patent Number(s):: 9,494,518

Application Number:: 14/415,779

OSTI ID:: 1332117

Resource Relation:: Patent File Date: 2013 Jul 18

Country of Publication:: United States

Language:: English

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