Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Brinker, Jeffrey C.; Ashley, Carlee Erin; Jiang, Xingmao; Liu, Juewen; Peabody, David S.; Wharton, Walker Richard; Carnes, Eric; Chackerian, Bryce; Willman, Cheryl L.

Title: Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Patent · Tue Nov 01 00:00:00 EDT 2016

OSTI ID:1330676

Brinker, Jeffrey C.; Ashley, Carlee Erin; Jiang, Xingmao; Liu, Juewen; Peabody, David S.; Wharton, Walker Richard; Carnes, Eric; Chackerian, Bryce; Willman, Cheryl L.

Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Number(s):: 9,480,653

Application Number:: 14/627,739

OSTI ID:: 1330676

Resource Relation:: Patent File Date: 2015 Feb 20

Country of Publication:: United States

Language:: English

References (19)

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