Carbon nanospikes grown on metal wires as microelectrode sensors for dopamine

Zestos, Alexander G.; Yang, Cheng; Jacobs, Christopher B.; Hensley, Dale; Venton, B. Jill

doi:10.1039/C5AN01467K

Title: Carbon nanospikes grown on metal wires as microelectrode sensors for dopamine

Journal Article · Mon Sep 14 00:00:00 EDT 2015 · Analyst

DOI:https://doi.org/10.1039/C5AN01467K· OSTI ID:1295130

Zestos, Alexander G. ^[1]; Yang, Cheng ^[1]; Jacobs, Christopher B. ^[2]; Hensley, Dale ^[3]; Venton, B. Jill ^[1]

Univ. of Virginia, Charlottesville, VA (United States)
Univ. of Virginia, Charlottesville, VA (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Carbon nanomaterials are advantageous as electrodes for neurotransmitter detection, but the difficulty of nanomaterials deposition on electrode substrates limits the reproducibility and future applications. In our study, we used plasma enhanced chemical vapor deposition (PECVD) to directly grow a thin layer of carbon nanospikes (CNS) on cylindrical metal substrates. No catalyst is required and the CNS surface coverage is uniform over the cylindrical metal substrate. We characterized the CNS growth on several metallic substrates including tantalum, niobium, palladium, and nickel wires. Using fast-scan cyclic voltammetry (FSCV), bare metal wires could not detect 1 mu M dopamine while carbon nanospike coated wires could. Moreover, the highest sensitivity and optimized S/N ratio was recorded from carbon nanospike-tantalum (CNS-Ta) microwires grown for 7.5 minutes, which had a LOD of 8 +/- 2 nM for dopamine with FSCV. CNS-Ta microelectrodes were more reversible and had a smaller Delta E-p for dopamine than carbon-fiber microelectrodes, suggesting faster electron transfer kinetics. The kinetics of dopamine redox were adsorption controlled at CNS-Ta microelectrodes and repeated electrochemical measurements displayed stability for up to ten hours in vitro and over a ten day period as well. The oxidation potential was significantly different for ascorbic acid and uric acid compared to dopamine. Finally, growing carbon nanospikes on metal wires is a promising method to produce uniformly-coated, carbon nanostructured cylindrical microelectrodes for sensitive dopamine detection.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1295130

Journal Information:: Analyst, Vol. 140, Issue 21; ISSN 0003-2654

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 42 works

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Carbon Nanotubes, Nanofibers and Nanospikes for Electrochemical Sensing: A Review Shanta, Aysha S.; Al Mamun, Khandakar A.; Islam, Syed K. International Journal of High Speed Electronics and Systems, Vol. 26, Issue 03 https://doi.org/10.1142/s0129156417400080	journal	June 2017
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