Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases

Huang, Edmond Y.; Inoue, Takuya; Leone, Vanessa A.; Dalal, Sushila; Touw, Ketrija; Wang, Yunwei; Musch, Mark W.; Theriault, Betty; Higuchi, Kazuhide; Donovan, Sharon; Gilbert, Jack; Chang, Eugene B.

doi:10.1097/mib.0000000000000332

Title: Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases

Journal Article · Fri May 01 00:00:00 EDT 2015 · Inflammatory Bowel Diseases

DOI:https://doi.org/10.1097/mib.0000000000000332· OSTI ID:1280876

Huang, Edmond Y. ^[1]; Inoue, Takuya ^[2]; Leone, Vanessa A. ^[1]; Dalal, Sushila ^[1]; Touw, Ketrija ^[1]; Wang, Yunwei ^[1]; Musch, Mark W. ^[1]; Theriault, Betty ^[1]; Higuchi, Kazuhide ^[2]; Donovan, Sharon ^[3]; Gilbert, Jack ^[4]; Chang, Eugene B. ^[1]

Univ. of Chicago, IL (United States). Knapp Center for Biomedical Discovery, Dept. of Medicine
Osaka Medical College, Takatsuki, Osaka (Japan). 2nd Dept. of Internal Medicine
Univ. of Illinois, Urbana, IL (United States). Dept. of Food Science and Human Nutrition
Argonne National Lab. (ANL), Argonne, IL (United States). Biosciences Division; Univ. of Chicago, IL (United States). Dept. of Ecology and Evolution; Marine Biological Laboratory, Woods Hole, MA (United States); Zhejiang Univ., Hangzhou (China). College of Environmental and Resource Sciences

Introduction—Commensal gut microbiota play an important role in regulating metabolic and inflammatory conditions. Reshaping intestinal microbiota through pharmacologic means may be a viable treatment option. Here we sought to delineate the functional characteristics of glucocorticoid-mediated alterations on gut microbiota and their subsequent repercussions on host mucin regulation and colonic inflammation. Methods—Adult male C57Bl/6 mice, germ-free (GF), Muc2-heterozygote (±), or Muc2-knockout (-/-) were injected with dexamethasone, a synthetic glucocorticoid, for four weeks. Fecal samples were collected for gut microbiota analysis via 16S rRNA T-RFLP and amplicon sequencing. Intestinal mucosa was collected for mucin gene expression studies. GF mice were conventionalized with gut microbes from treated- and non-treated groups to determine their functional capacities in recipient hosts. Results—Exposure to DEX in WT mice led to substantial shifts in gut microbiota over a four-week period. Furthermore, a significant down-regulation of colonic Muc2 gene expression was observed after treatment. Muc2-knockout mice harbored a pro-inflammatory environment of gut microbes, characterized by the increase or decrease in prevalence of specific microbiota populations such as Clostridiales and Lactobacillaceae, respectively. This colitogenic phenotype was transmissible to IL10-knockout (IL10-KO) mice, a genetically susceptible model of colonic inflammatory disorders. Microbiota from donors pre-treated with DEX, however, ameliorated symptoms of inflammation. We conclude that commensal gut bacteria may be a key mediator of the anti-inflammatory effects observed in the large intestine after GC exposure. These findings underscore the notion that intestinal microbes comprise a “microbial organ” essential for host physiology that can be targeted by therapeutic approaches to restore intestinal homeostasis.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

Grant/Contract Number:: DK-42086; DK097268; T32 DK07074; DK47722; NIDDK UH3DK083993

OSTI ID:: 1280876

Journal Information:: Inflammatory Bowel Diseases, Vol. 21, Issue 5; ISSN 1078-0998

Publisher:: Crohn's & Colitis Foundation of AmericaCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 115 works

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References (59)

Microbial Influences in Inflammatory Bowel Diseases Sartor, R. Balfour Gastroenterology, Vol. 134, Issue 2 https://doi.org/10.1053/j.gastro.2007.11.059	journal	February 2008
The Role of Microbes in Crohn's Disease Eckburg, P. B.; Relman, D. A. Clinical Infectious Diseases, Vol. 44, Issue 2 https://doi.org/10.1086/510385	journal	January 2007
Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2 Velcich, A. Science, Vol. 295, Issue 5560 https://doi.org/10.1126/science.1069094	journal	March 2002
Oral glucocorticoids and their complications Gallant, C.; Kenny, P. Journal of the American Academy of Dermatology, Vol. 14, Issue 2 https://doi.org/10.1016/S0190-9622(86)70018-2	journal	February 1986
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice Devkota, Suzanne; Wang, Yunwei; Musch, Mark W. Nature, Vol. 487, Issue 7405 https://doi.org/10.1038/nature11225	journal	June 2012
The Short-Term Effects of Different Doses of Dexamethasone on the Numbers of some Bacteria in the Ileum Ünsal, Hümeyra; Balkaya, Muharrem; Ünsal, Cengiz Digestive Diseases and Sciences, Vol. 53, Issue 7 https://doi.org/10.1007/s10620-007-0089-6	journal	November 2007
Newly Developed Antibiotic Combination Therapy for Ulcerative Colitis: A Double-Blind Placebo-Controlled Multicenter Trial Ohkusa, Toshifumi; Kato, Kimitoshi; Terao, Shuichi American Journal of Gastroenterology, Vol. 105, Issue 8 https://doi.org/10.1038/ajg.2010.84	journal	January 2010
Shift Towards Pro-inflammatory Intestinal Bacteria Aggravates Acute Murine Colitis via Toll-like Receptors 2 and 4 Heimesaat, Markus M.; Fischer, André; Siegmund, Britta PLoS ONE, Vol. 2, Issue 7 https://doi.org/10.1371/journal.pone.0000662	journal	July 2007
IBD—what role do Proteobacteria play? Mukhopadhya, Indrani; Hansen, Richard; El-Omar, Emad M. Nature Reviews Gastroenterology & Hepatology, Vol. 9, Issue 4 https://doi.org/10.1038/nrgastro.2012.14	journal	February 2012
Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection Van der Sluis, Maria; De Koning, Barbara A. E.; De Bruijn, Adrianus C. J. M. Gastroenterology, Vol. 131, Issue 1 https://doi.org/10.1053/j.gastro.2006.04.020	journal	July 2006
Mechanisms of glucocorticoid receptor signaling during inflammation Smoak, Kathleen A.; Cidlowski, John A. Mechanisms of Ageing and Development, Vol. 125, Issue 10-11 https://doi.org/10.1016/j.mad.2004.06.010	journal	October 2004
The natural history of corticosteroid therapy for inflammatory bowel disease: A population-based study Faubion, William A.; Loftus, Edward V.; Harmsen, William S. Gastroenterology, Vol. 121, Issue 2 https://doi.org/10.1053/gast.2001.26279	journal	August 2001
Colonization With Distinct Proteobacteria Provocateurs Induces Multifactorial Gastrointestinal Inflammation That Is Regulated by CD4+ T Cells: P-194 Ramer-Tait, Amanda; Overstreet, Anne-Marie; Hostetter, Jesse Inflammatory Bowel Diseases, Vol. 18 https://doi.org/10.1097/00054725-201212001-00227	journal	January 2012
Unravelling the pathogenesis of inflammatory bowel disease Xavier, R. J.; Podolsky, D. K. Nature, Vol. 448, Issue 7152 https://doi.org/10.1038/nature06005	journal	July 2007
Biosynthesis of rat MUC2 in colon and its analogy with human MUC2 Tytgat, K. M. A. J.; Bovelander, F. J.; Opdam, F. J. M. Biochemical Journal, Vol. 309, Issue 1 https://doi.org/10.1042/bj3090221	journal	July 1995
Innate immunity and intestinal microbiota in the development of Type 1 diabetes Wen, Li; Ley, Ruth E.; Volchkov, Pavel Yu. Nature, Vol. 455, Issue 7216 https://doi.org/10.1038/nature07336	journal	September 2008
Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease Bloom, Seth M.; Bijanki, Vinieth N.; Nava, Gerardo M. Cell Host & Microbe, Vol. 9, Issue 5 https://doi.org/10.1016/j.chom.2011.04.009	journal	May 2011
Genome-scale analyses of health-promoting bacteria: probiogenomics Ventura, Marco; O'Flaherty, Sarah; Claesson, Marcus J. Nature Reviews Microbiology, Vol. 7, Issue 1 https://doi.org/10.1038/nrmicro2047	journal	November 2008
Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice: Commensal microbiota and stress response Sudo, Nobuyuki; Chida, Yoichi; Aiba, Yuji The Journal of Physiology, Vol. 558, Issue 1 https://doi.org/10.1113/jphysiol.2004.063388	journal	June 2004
The Role of Microbiota and Probiotics in Stress-Induced Gastrointestinal Damage Lutgendorff, Femke; Akkermans, Louis; Soderholm, Johan Current Molecular Medicine, Vol. 8, Issue 4 https://doi.org/10.2174/156652408784533779	journal	June 2008
Diversity, stability and resilience of the human gut microbiota Lozupone, Catherine A.; Stombaugh, Jesse I.; Gordon, Jeffrey I. Nature, Vol. 489, Issue 7415 https://doi.org/10.1038/nature11550	journal	September 2012
Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases Packey, Christopher D.; Sartor, R. Balfour Current Opinion in Infectious Diseases, Vol. 22, Issue 3 https://doi.org/10.1097/QCO.0b013e32832a8a5d	journal	January 2009
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer Deplancke, Bart; Gaskins, H. Rex The American Journal of Clinical Nutrition, Vol. 73, Issue 6 https://doi.org/10.1093/ajcn/73.6.1131S	journal	June 2001
Role of commensal gut bacteria in inflammatory bowel diseases Loh, Gunnar; Blaut, Michael Gut Microbes, Vol. 3, Issue 6 https://doi.org/10.4161/gmic.22156	journal	November 2012
Variation of mucin distribution in the rat intestine, caecum and colon: effect of the bacterial flora Meslin, Jean-Claude; Fontaine, Nicole; Andrieux, Claude Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Vol. 123, Issue 3 https://doi.org/10.1016/S1095-6433(99)00056-2	journal	July 1999
Glucocorticoid responsiveness in developing human intestine: possible role in prevention of necrotizing enterocolitis Nanthakumar, N. Nanda; Young, Cheryl; Ko, Jae Sung American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 288, Issue 1 https://doi.org/10.1152/ajpgi.00169.2004	journal	January 2005
Obesity alters gut microbial ecology Ley, R. E.; Backhed, F.; Turnbaugh, P. Proceedings of the National Academy of Sciences, Vol. 102, Issue 31 https://doi.org/10.1073/pnas.0504978102	journal	July 2005
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5 Vijay-Kumar, M.; Aitken, J. D.; Carvalho, F. A. Science, Vol. 328, Issue 5975 https://doi.org/10.1126/science.1179721	journal	March 2010
Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation de La Serre, Claire Barbier; Ellis, Collin L.; Lee, Jennifer American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 299, Issue 2 https://doi.org/10.1152/ajpgi.00098.2010	journal	August 2010
New IBD genetics: common pathways with other diseases Lees, C. W.; Barrett, J. C.; Parkes, M. Gut, Vol. 60, Issue 12 https://doi.org/10.1136/gut.2009.199679	journal	February 2011
On communication between gut microbes and the brain Forsythe, Paul; Kunze, Wolfgang A.; Bienenstock, John Current Opinion in Gastroenterology, Vol. 28, Issue 6 https://doi.org/10.1097/MOG.0b013e3283572ffa	journal	January 2012
Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin Tytgat, Kristien M. A. J.; Büller, Hans A.; Opdam, Frank J. M. Gastroenterology, Vol. 107, Issue 5 https://doi.org/10.1016/0016-5085(94)90537-1	journal	November 1994
Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses O'Mahony, Siobhain M.; Marchesi, Julian R.; Scully, Paul Biological Psychiatry, Vol. 65, Issue 3 https://doi.org/10.1016/j.biopsych.2008.06.026	journal	February 2009
Immunosuppression by Glucocorticoids: Inhibition of NF-kappaB Activity Through Induction of IkappaB Sy nthesis Auphan, N.; DiDonato, J. A.; Rosette, C. Science, Vol. 270, Issue 5234 https://doi.org/10.1126/science.270.5234.286	journal	October 1995
Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation Riedel, Christian U. World Journal of Gastroenterology, Vol. 12, Issue 23 https://doi.org/10.3748/wjg.v12.i23.3729	journal	January 2006
Review article: issues in oral administration of locally acting glucocorticosteroids for treatment of inflammatory bowel disease Alimentary Pharmacology and Therapeutics, Vol. 12, Issue 7 https://doi.org/10.1046/j.1365-2036.1998.00348.x	journal	July 1998
High incidence of serious side effects of high-dose dexamethasone treatment in patients with epidural spinal cord compression Heimdal, Ketil; Hirschberg, Henry; Sletteb�, Haldor Journal of Neuro-Oncology, Vol. 12, Issue 2 https://doi.org/10.1007/BF00172664	journal	February 1992
Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast, and ovary Hanski, C.; Hofmeier, M.; Schmitt-Gräff, A. The Journal of Pathology, Vol. 182, Issue 4 https://doi.org/10.1002/(SICI)1096-9896(199708)182:4<385::AID-PATH861>3.0.CO;2-Q	journal	August 1997
Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types Blank, Monika; Klussmann, Enno; Krüger-Krasagakes, Sabine International Journal of Cancer, Vol. 59, Issue 3 https://doi.org/10.1002/ijc.2910590302	journal	November 1994
Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice Madsen, Karen L.; Doyle, Jason S.; Jewell, Laurence D. Gastroenterology, Vol. 116, Issue 5 https://doi.org/10.1016/S0016-5085(99)70013-2	journal	May 1999
Composition of Dietary Fat Source Shapes Gut Microbiota Architecture and Alters Host Inflammatory Mediators in Mouse Adipose Tissue Huang, Edmond Y.; Leone, Vanessa A.; Devkota, Suzanne Journal of Parenteral and Enteral Nutrition, Vol. 37, Issue 6 https://doi.org/10.1177/0148607113486931	journal	May 2013
Adaptation of the bicinchoninic acid protein assay for use with microtiter plates and sucrose gradient fractions Redinbaugh, Margaret G.; Turley, Rickie B. Analytical Biochemistry, Vol. 153, Issue 2 https://doi.org/10.1016/0003-2697(86)90091-6	journal	March 1986
T-REX: software for the processing and analysis of T-RFLP data Culman, Steven W.; Bukowski, Robert; Gauch, Hugh G. BMC Bioinformatics, Vol. 10, Issue 1 https://doi.org/10.1186/1471-2105-10-171	journal	June 2009
The gut microbiota shapes intestinal immune responses during health and disease Round, June L.; Mazmanian, Sarkis K. Nature Reviews Immunology, Vol. 9, Issue 5 https://doi.org/10.1038/nri2515	journal	May 2009
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis Elinav, Eran; Strowig, Till; Kau, Andrew L. Cell, Vol. 145, Issue 5 https://doi.org/10.1016/j.cell.2011.04.022	journal	May 2011
The HPA axis in major depression: classical theories and new developments Pariante, Carmine M.; Lightman, Stafford L. Trends in Neurosciences, Vol. 31, Issue 9 https://doi.org/10.1016/j.tins.2008.06.006	journal	September 2008
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria Johansson, M. E. V.; Phillipson, M.; Petersson, J. Proceedings of the National Academy of Sciences, Vol. 105, Issue 39 https://doi.org/10.1073/pnas.0803124105	journal	September 2008
Selective Inhibition of NF-kB Activation and TNF-α Production in Macrophages by Red Blood Cell-Mediated Delivery of Dexamethasone Crinelli, Rita; Antonelli, Antonella; Bianchi, Marzia Blood Cells, Molecules, and Diseases, Vol. 26, Issue 3 https://doi.org/10.1006/bcmd.2000.0298	journal	June 2000
The Human Gut Microbiome and Body Metabolism: Implications for Obesity and Diabetes Devaraj, S.; Hemarajata, P.; Versalovic, J. Clinical Chemistry, Vol. 59, Issue 4 https://doi.org/10.1373/clinchem.2012.187617	journal	February 2013
The control and consequences of bacterial fermentation in the human colon Cummings, J. H.; Macfarlane, G. T. Journal of Applied Bacteriology, Vol. 70, Issue 6 https://doi.org/10.1111/j.1365-2672.1991.tb02739.x	journal	June 1991
Mucin degradation in the human gastrointestinal tract and its significance to enteric microbial ecology Hoskins, Lansing C. European Journal of Gastroenterology & Hepatology, Vol. 5, Issue 4 https://doi.org/10.1097/00042737-199304000-00004	journal	January 1993
Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Scheinman, R. I.; Gualberto, A.; Jewell, C. M. Molecular and Cellular Biology, Vol. 15, Issue 2 https://doi.org/10.1128/MCB.15.2.943	journal	February 1995
Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms Barnes, Peter J. Clinical Science, Vol. 94, Issue 6 https://doi.org/10.1042/cs0940557	journal	June 1998
Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial Furrie, E. Gut, Vol. 54, Issue 2 https://doi.org/10.1136/gut.2004.044834	journal	February 2005
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity Henao-Mejia, Jorge; Elinav, Eran; Jin, Chengcheng Nature, Vol. 482, Issue 7384 https://doi.org/10.1038/nature10809	journal	February 2012
Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice van der Sluis, Maria; Bouma, Janneke; Vincent, Audrey Laboratory Investigation, Vol. 88, Issue 6 https://doi.org/10.1038/labinvest.2008.28	journal	April 2008
Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice Sellon, Rance K.; Tonkonogy, Susan; Schultz, Michael Infection and Immunity, Vol. 66, Issue 11 https://doi.org/10.1128/IAI.66.11.5224-5231.1998	journal	November 1998
Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. A., Cidlowski, J.; A., Gualberto,; S., Baldwin, A. The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/yy65-ff95	text	January 1995
Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases Balfour, Sartor, R.; D., Packey, Christopher The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/akhx-e124	text	January 2009

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