Ebolavirus comparative genomics

Jun, Se-Ran; Leuze, Michael R.; Nookaew, Intawat; Uberbacher, Edward C.; Land, Miriam; Zhang, Qian; Wanchai, Visanu; Chai, Juanjuan; Nielsen, Morten; Trolle, Thomas; Lund, Ole; Buzard, Gregory S.; Pedersen, Thomas D.; Wassenaar, Trudy M.; Ussery, David W.

doi:10.1093/femsre/fuv031

Title: Ebolavirus comparative genomics

Journal Article · Tue Jul 14 00:00:00 EDT 2015 · FEMS Microbiology Reviews

DOI:https://doi.org/10.1093/femsre/fuv031· OSTI ID:1265422

Jun, Se-Ran ^[1]; Leuze, Michael R. ^[2]; Nookaew, Intawat ^[3]; Uberbacher, Edward C. ^[3]; Land, Miriam ^[3]; Zhang, Qian ^[4]; Wanchai, Visanu ^[3]; Chai, Juanjuan ^[2]; Nielsen, Morten ^[5]; Trolle, Thomas ^[6]; Lund, Ole ^[6]; Buzard, Gregory S. ^[7]; Pedersen, Thomas D. ^[8]; Wassenaar, Trudy M. ^[9]; Ussery, David W. ^[4]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division; Univ. of Tennessee, Knoxville, TN (United States). Joint Inst. for Computational Sciences
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Computer Science and Mathematics Division
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division; Univ. of Tennessee, Knoxville, TN (United States). UT-ORNL Graduate School of Genome Science and Technology
Technical Univ. of Denmark, Lyngby (Denmark). Center for Biological Sequence Analysis; Univ. Nacional de San Martin, Buenos Aires (Argentina)
Technical Univ. of Denmark, Lyngby (Denmark). Center for Biological Sequence Analysis
Booze Allen Hamilton, McLean, VA (United States)
Technical Univ. of Denmark, Lyngby (Denmark). Center for Biological Sequence Analysis; Chr. Hansen A/S, Horsholm (Denmark). Assays, Cultures and Enzymes Division
Microbiology and Genomics Consultants, Zotzenheim (Germany)

The 2014 Ebola outbreak in West Africa is the largest documented for this virus. We examine the dynamics of this genome, comparing more than one hundred currently available ebolavirus genomes to each other and to other viral genomes. Based on oligomer frequency analysis, the family Filoviridae forms a distinct group from all other sequenced viral genomes. All filovirus genomes sequenced to date encode proteins with similar functions and gene order, although there is considerable divergence in sequences between the three genera Ebolavirus, Cuevavirus, and Marburgvirus within the family Filoviridae. Whereas all ebolavirus genomes are quite similar (multiple sequences of the same strain are often identical), variation is most common in the intergenic regions and within specific areas of the genes encoding the glycoprotein (GP), nucleoprotein (NP), and polymerase (L). We predict regions that could contain epitope-binding sites, which might be good vaccine targets. In conclusion, this information, combined with glycosylation sites and experimentally determined epitopes, can identify the most promising regions for the development of therapeutic strategies.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1265422

Journal Information:: FEMS Microbiology Reviews, Vol. 39, Issue 5; ISSN 1574-6976

Publisher:: Federation of European Microbiological SocietiesCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 33 works

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