The Macromolecular Neutron Diffractometer MaNDi at the Spallation Neutron Source

Coates, Leighton; Cuneo, Matthew J.; Frost, Matthew J.; He, Junhong; Weiss, Kevin L.; McFeeters, Hana; Tomanicek, Stephen J.; Vandavasi, Venu Gopal; Langan, Paul; Iverson, Erik B.

doi:10.1107/S1600576715011243

Title: The Macromolecular Neutron Diffractometer MaNDi at the Spallation Neutron Source

Journal Article · Sat Jul 18 00:00:00 EDT 2015 · Journal of Applied Crystallography (Online)

DOI:https://doi.org/10.1107/S1600576715011243· OSTI ID:1261457

Coates, Leighton ^[1]; Cuneo, Matthew J. ^[1]; Frost, Matthew J. ^[1]; He, Junhong ^[1]; Weiss, Kevin L. ^[1]; McFeeters, Hana ^[1]; Tomanicek, Stephen J. ^[1]; Vandavasi, Venu Gopal ^[1]; Langan, Paul ^[1]; Iverson, Erik B. ^[1]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

The Macromolecular Neutron Diffractometer (MaNDi) is located on beamline 11B of the Spallation Neutron Source at Oak Ridge National Laboratory. Moreover, the instrument is a neutron time-of-flight wavelength-resolved Laue diffractometer optimized to collect diffraction data from single crystals. Finally, the instrument has been designed to provide flexibility in several instrumental parameters, such as beam divergence and wavelength bandwidth, to allow data collection from a range of macromolecular systems.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Structural Molecular Biology (CSMB)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1261457

Journal Information:: Journal of Applied Crystallography (Online), Vol. 48, Issue 4; ISSN 1600-5767

Publisher:: International Union of CrystallographyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 51 works

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Neutron structure of type-III antifreeze protein allows the reconstruction of AFP-ice interface Howard, Eduardo I.; Blakeley, Matthew P.; Haertlein, Michael Journal of Molecular Recognition, Vol. 24, Issue 4 https://doi.org/10.1002/jmr.1130	journal	April 2011
Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase Casadei, C. M.; Gumiero, A.; Metcalfe, C. L. Science, Vol. 345, Issue 6193 https://doi.org/10.1126/science.1254398	journal	July 2014
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Application of profile fitting method to neutron time-of-flight protein single crystal diffraction data collected at the iBIX Yano, Naomine; Yamada, Taro; Hosoya, Takaaki Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep36628	journal	December 2016
Neutron macromolecular crystallography Blakeley, Matthew P.; Podjarny, Alberto D. Emerging Topics in Life Sciences, Vol. 2, Issue 1 https://doi.org/10.1042/etls20170083	journal	February 2018
A suite-level review of the neutron single-crystal diffraction instruments at Oak Ridge National Laboratory Coates, L.; Cao, H. B.; Chakoumakos, B. C. Review of Scientific Instruments, Vol. 89, Issue 9 https://doi.org/10.1063/1.5030896	journal	September 2018
BraggNet: integrating Bragg peaks using neural networks Sullivan, Brendan; Archibald, Rick; Azadmanesh, Jahaun Journal of Applied Crystallography, Vol. 52, Issue 4 https://doi.org/10.1107/s1600576719008665	journal	July 2019
Cryo-neutron crystallographic data collection and preliminary refinement of left-handed Z-DNA d(CGCGCG) Harp, Joel M.; Coates, Leighton; Sullivan, Brendan Acta Crystallographica Section F Structural Biology Communications, Vol. 74, Issue 10 https://doi.org/10.1107/s2053230x1801066x	journal	September 2018
Redox manipulation of the manganese metal in human manganese superoxide dismutase for neutron diffraction Azadmanesh, Jahaun; Lutz, William E.; Weiss, Kevin L. Acta Crystallographica Section F Structural Biology Communications, Vol. 74, Issue 10 https://doi.org/10.1107/s2053230x18011299	journal	September 2018
Perdeuteration, large crystal growth and neutron data collection of Leishmania mexicana triose-phosphate isomerase E65Q variant Kelpšas, Vinardas; Lafumat, Bénédicte; Blakeley, Matthew P. Acta Crystallographica Section F Structural Biology Communications, Vol. 75, Issue 4 https://doi.org/10.1107/s2053230x19001882	journal	April 2019
Crystallization of a potassium ion channel and X-ray and neutron data collection Langan, Patricia S.; Vandavasi, Venu Gopal; Sullivan, Brendan Acta Crystallographica Section F Structural Biology Communications, Vol. 75, Issue 6 https://doi.org/10.1107/s2053230x19006630	journal	May 2019
The rise of neutron cryo-crystallography Kwon, Hanna; Langan, Patricia S.; Coates, Leighton Acta Crystallographica Section D Structural Biology, Vol. 74, Issue 8 https://doi.org/10.1107/s205979831800640x	journal	July 2018
Improving the accuracy and resolution of neutron crystallographic data by three-dimensional profile fitting of Bragg peaks in reciprocal space Sullivan, Brendan; Archibald, Rick; Langan, Patricia S. Acta Crystallographica Section D Structural Biology, Vol. 74, Issue 11 https://doi.org/10.1107/s2059798318013347	journal	October 2018
Neutron scattering in the biological sciences: progress and prospects Ashkar, Rana; Bilheux, Hassina Z.; Bordallo, Heliosa Acta Crystallographica Section D Structural Biology, Vol. 74, Issue 12 https://doi.org/10.1107/s2059798318017503	journal	December 2018
A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad Kumar, Prashasti; Serpersu, Engin H.; Cuneo, Matthew J. Science Advances, Vol. 4, Issue 4 https://doi.org/10.1126/sciadv.aas8667	journal	April 2018
A Review of the Catalytic Mechanism of Human Manganese Superoxide Dismutase Azadmanesh, Jahaun; Borgstahl, Gloria Antioxidants, Vol. 7, Issue 2 https://doi.org/10.3390/antiox7020025	journal	January 2018
BraggNet: integrating Bragg peaks using neural networks Sullivan, Brendan; Archibald, Rick; Azadmanesh, Jahaun International Union of Crystallography (IUCr) https://doi.org/10.1107/s1600576719008665/fs5173sup2.pdf	text	January 2019
BraggNet: integrating Bragg peaks using neural networks Sullivan, Brendan; Archibald, Rick; Azadmanesh, Jahaun International Union of Crystallography (IUCr) https://doi.org/10.1107/s1600576719008665/fs5173sup1.pdf	text	January 2019

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46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
MaNDi
Spallation Neutron Source
neutron diffractometers
PROTEIN CRYSTALLOGRAPHY
ALDOSE REDUCTASE
X-RAY
DIFFRACTION

Title: The Macromolecular Neutron Diffractometer MaNDi at the Spallation Neutron Source

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