Proton mediated control of biochemical reactions with bioelectronic pH modulation

Deng, Yingxin; Miyake, Takeo; Keene, Scott; Josberger, Erik E.; Rolandi, Marco

doi:10.1038/srep24080

Title: Proton mediated control of biochemical reactions with bioelectronic pH modulation

Journal Article · Thu Apr 07 00:00:00 EDT 2016 · Scientific Reports

DOI:https://doi.org/10.1038/srep24080· OSTI ID:1253913

Deng, Yingxin ^[1]; Miyake, Takeo ^[2]; Keene, Scott ^[1]; Josberger, Erik E. ^[1]; Rolandi, Marco ^[2]

Univ. of Washington, Seattle, WA (United States)
Univ. of Washington, Seattle, WA (United States); Univ. of California, Santa Cruz, CA (United States)

In Nature, protons (H⁺) can mediate metabolic process through enzymatic reactions. Examples include glucose oxidation with glucose dehydrogenase to regulate blood glucose level, alcohol dissolution into carboxylic acid through alcohol dehydrogenase, and voltage-regulated H⁺ channels activating bioluminescence in firefly and jellyfish. Artificial devices that control H⁺ currents and H⁺ concentration (pH) are able to actively influence biochemical processes. Here, we demonstrate a biotransducer that monitors and actively regulates pH-responsive enzymatic reactions by monitoring and controlling the flow of H⁺ between PdH_x contacts and solution. The present transducer records bistable pH modulation from an “enzymatic flip-flop” circuit that comprises glucose dehydrogenase and alcohol dehydrogenase. Furthermore, the transducer also controls bioluminescence from firefly luciferase by affecting solution pH.

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Research Organization:: Univ. of Washington, Seattle, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0010441

OSTI ID:: 1253913

Journal Information:: Scientific Reports, Vol. 6; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 19 works

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