skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Patent ·
OSTI ID:1248479

The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-06CH11357
Assignee:
UCHICAGO ARGONNE, LLC (Chicago, IL)
Patent Number(s):
9,312,037
Application Number:
13/399,082
OSTI ID:
1248479
Resource Relation:
Patent File Date: 2012 Feb 17
Country of Publication:
United States
Language:
English

References (23)

Production of no-carrier added 67Cu
  • Mirzadeh, S.; Mausner, L. F.; Srivastava, S. C.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 37, Issue 1, p. 29-36 https://doi.org/10.1016/0883-2889(86)90192-9
journal January 1986
Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions journal April 2004
The production of copper 67 from natural zinc using a linear accelerator journal November 1970
The Preparation of High Specific Activity Copper 64 journal January 1964
Process of Casting Titanium and Related Metal and Alloys patent September 1957
Process for Separating Iodine-132 from Fission Products patent June 1960
Melting and Casting of Titanium patent December 1968
Separation Metals patent December 1968
Radioisotope Fuel Capsule patent November 1971
Radioactive waste material melter apparatus patent April 1990
Polymer beads containing an immobilized extractant for sorbing metals from solution patent January 1994
Glass gob drop guide funnel assembly patent March 1995
Extrusion-resistant seal assembly patent June 1995
Method of producing molybdenum-99 patent July 1998
Production of radioisotopes with a high specific activity by isotopic conversion patent September 1999
Production of radioisotopes with a high specific activity by isotopic conversion patent March 2001
Production of high specific activity copper -67 patent December 2002
Devices and methods for melting materials patent October 2007
Sublimation purifying method and apparatus patent-application February 2003
Devices and methods for melting materials patent-application September 2014
Process for extraction of metals from ores or industrial materials patent-application February 2006
Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications patent-application February 2010
Nanostructured Target for Isotope Production patent-application September 2011