Bio-corrosion and cytotoxicity studies on novel Zr55Co30Ti15 and Cu60Zr20Ti20 metallic glasses
- Visvesvaraya National Institute of Technology, Nagour (India)
- National Environmental Engineering Research Institute, Nagpur (India)
- Ames Lab., Ames, IA (United States)
- Iowa State Univ., Ames, IA (United States)
- Indian Inst. of Technology (IIT), Madras (India)
Metallic glasses are a potential and compatible implant candidate for biomedical applications. In the present investigation, a comparative study between novel Zr55Co30Ti15 and Cu60Zr20Ti20 metallic glasses is carried out to evaluate in vitro biocompatibility using simulated body fluids. The bio-corrosion behavior of Zr- and Cu-based metallic glasses in different types of artificial body fluids such as artificial saliva solution, phosphate-buffered saline solution, artificial blood plasma solution, and Hank’s balanced saline solution is evaluated using potentiodynamic polarization studies at a constant body temperature of 310.15 K (37 °C). Surface morphology of samples after bio-corrosion experiments was observed by scanning electron microscopy. In vitro cytotoxicity test on glassy alloys were performed using human osteosarcoma cell line as per 10993-5 guidelines from International Organization for Standardization. As a result, the comparative study between Zr- and Cu-based glassy alloys provides vital information about the effect of elemental composition on biocompatibility of metallic glasses.
- Research Organization:
- Ames Lab., Ames, IA (United States)
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- AC02-07CH11358
- OSTI ID:
- 1227146
- Report Number(s):
- IS-J-8662; PII: 2574
- Journal Information:
- Metallurgical and Materials Transactions. A, Physical Metallurgy and Materials Science, Vol. 46, Issue 6; ISSN 1073-5623
- Publisher:
- ASM InternationalCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
Recent Advancements in Bulk Metallic Glasses and Their Applications: A Review
|
journal | August 2017 |
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Related Subjects
60 APPLIED LIFE SCIENCES
glassy alloy
ho cell
metallic glass
artificial saliva solution
ho cell line
artificial body fluid
SBF solution
melt-spun alloy
potentiodynamic polarization
316L stainless steel
passive film
osteosarcoma cell line
simulated body fluid
corrosion behavior
cell viability