Bio-corrosion and cytotoxicity studies on novel Zr55Co30Ti15 and Cu60Zr20Ti20 metallic glasses

Vincent, S.; Daiwile, A.; Devi, S. S.; Kramer, M. J.; Besser, M. F.; Murty, B. S.; Bhatt, Jatin

doi:10.1007/s11661-014-2574-9

Title: Bio-corrosion and cytotoxicity studies on novel Zr₅₅Co₃₀Ti₁₅ and Cu₆₀Zr₂₀Ti₂₀ metallic glasses

Journal Article · Fri Sep 26 00:00:00 EDT 2014 · Metallurgical and Materials Transactions. A, Physical Metallurgy and Materials Science

DOI:https://doi.org/10.1007/s11661-014-2574-9· OSTI ID:1227146

Vincent, S. ^[1]; Daiwile, A. ^[2]; Devi, S. S. ^[2]; Kramer, M. J. ^[3]; Besser, M. F. ^[4]; Murty, B. S. ^[5]; Bhatt, Jatin ^[1]

Visvesvaraya National Institute of Technology, Nagour (India)
National Environmental Engineering Research Institute, Nagpur (India)
Ames Lab., Ames, IA (United States)
Iowa State Univ., Ames, IA (United States)
Indian Inst. of Technology (IIT), Madras (India)

Metallic glasses are a potential and compatible implant candidate for biomedical applications. In the present investigation, a comparative study between novel Zr₅₅Co₃₀Ti₁₅ and Cu₆₀Zr₂₀Ti₂₀ metallic glasses is carried out to evaluate in vitro biocompatibility using simulated body fluids. The bio-corrosion behavior of Zr- and Cu-based metallic glasses in different types of artificial body fluids such as artificial saliva solution, phosphate-buffered saline solution, artificial blood plasma solution, and Hank’s balanced saline solution is evaluated using potentiodynamic polarization studies at a constant body temperature of 310.15 K (37 °C). Surface morphology of samples after bio-corrosion experiments was observed by scanning electron microscopy. In vitro cytotoxicity test on glassy alloys were performed using human osteosarcoma cell line as per 10993-5 guidelines from International Organization for Standardization. As a result, the comparative study between Zr- and Cu-based glassy alloys provides vital information about the effect of elemental composition on biocompatibility of metallic glasses.

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Research Organization:: Ames Lab., Ames, IA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-07CH11358

OSTI ID:: 1227146

Report Number(s):: IS-J-8662; PII: 2574

Journal Information:: Metallurgical and Materials Transactions. A, Physical Metallurgy and Materials Science, Vol. 46, Issue 6; ISSN 1073-5623

Publisher:: ASM InternationalCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 10 works

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Title: Bio-corrosion and cytotoxicity studies on novel Zr55Co30Ti15 and Cu60Zr20Ti20 metallic glasses

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Title: Bio-corrosion and cytotoxicity studies on novel Zr₅₅Co₃₀Ti₁₅ and Cu₆₀Zr₂₀Ti₂₀ metallic glasses