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Title: Biological detector and method

Patent ·
OSTI ID:1226815

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Research Organization:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000
Assignee:
STC.UNM (Albuquerque, NM)
Patent Number(s):
9,194,921
Application Number:
13/717,412
OSTI ID:
1226815
Resource Relation:
Patent File Date: 2012 Dec 17
Country of Publication:
United States
Language:
English

References (95)

Nuclear magnetic resonance net organic flowmeter patent February 1990
Reversible agglutination mediators patent August 1992
Solvent mediated relaxation assay system patent November 1992
Solvent mediated relaxation assay system patent October 1993
Detection of biological macromolecules by NMR-sensitive labels patent August 1994
Method and apparatus for NMR spectroscopy of nanoliter volume samples patent August 1997
Dry chemistry cascade immunoassay and affinity assay patent October 1997
Apparatus and method for compensation of magnetic susceptibility variation in NMR microspectroscopy detection microcoils patent November 1997
Variable external capacitor for NMR probe patent June 1998
Method and device for determining an analyte in a sample patent June 1998
Method and device for the determination of an analyte using super paramagnetic reactive particles patent July 1999
Microcoil based micro-NMR spectrometer and method patent August 2000
Integrated miniaturized device for processing and NMR detection of liquid phase samples patent February 2001
MR device provided with a medical instrument, and method of determining the position of the medical instrument patent May 2001
Field-frequency lock system for magnetic resonance system patent June 2001
Methods for high throughput chemical screening using magnetic resonance imaging patent October 2001
NMR of thin layers using a meanderline surface coil patent December 2001
Nanoparticles having oligonucleotides attached thereto and uses therefor patent March 2002
MR method utilizing microcoils situated in the examination zone patent May 2002
Method and apparatus for simultaneous acquisition of high resolution NMR spectra from multiple samples patent September 2002
Device for high gain and uniformly localized magnetic resonance imaging patent November 2002
MR method for exciting the nuclear magnetization in a limited volume patent January 2003
Microcoil device with a forward field-of-view for large gain magnetic resonance imaging patent July 2003
Method and apparatus for generating controlled torques on objects particularly objects inside a living body patent July 2003
Nuclear magnetic resonance analysis of multiple samples patent February 2004
Multistage electromagnetic separator for purifying cells, chemicals and protein structures patent March 2004
Microcoil based micro-NMR spectrometer and method patent September 2004
Microfluidic device with multiple microcoil NMR detectors and field gradient focusing patent November 2004
Low-field MRI patent January 2005
Nuclear magnetic resonance analysis of multiple samples patent October 2005
Method and apparatus for intracorporeal medical imaging using a self-tuned coil patent August 2006
Microfluidic device with multiple microcoil NMR detectors enabling fluidic series communication patent November 2006
Localized two-dimensional shift correlated MR spectroscopy of human brain patent April 2007
Anisotropic nanoparticle amplification of magnetic resonance signals patent April 2007
Toroid cavity/coil NMR multi-detector patent September 2007
Integrated on-chip NMR and ESR device and method for making and using the same patent September 2007
Portable NMR device and method for making and using the same patent March 2008
Electron spin resonance microscope for imaging with micron resolution patent July 2008
Tuning low-inductance coils at low frequencies patent July 2008
NMR device for detection of analytes patent July 2009
NMR device for detection of analytes patent January 2012
Microcoil magnetic resonance detectors patent March 2012
NMR device for detection of analytes patent December 2012
Biological detector and method patent February 2013
Biological detector and method patent April 2014
Nuclear magnetic resonance analysis of multiple samples patent-application September 2002
Multistage electromagnetic separator for purifying cells, chemicals and protein structures patent-application October 2002
Method of localizing an object in an MR apparatus, a catheter and an MR apparatus for carrying out the method patent-application May 2003
Magneitc-nanoparticle conjugates and methods of use patent-application May 2003
Batch-fabricated gradient glossary patent-application December 2003
Microfluidic devices for high gradient magnetic separation patent-application January 2004
Catheter tracking with phase information patent-application November 2005
NMR device for detection of analytes patent-application May 2007
Integrated On-Chip NMR and ESR Device and Method for Making and Using the Same patent-application July 2007
Portable NMR device and method for making and using the same patent-application July 2007
Biological Detector and Method patent-application August 2008
Microcoil NMR Detectors patent-application November 2008
Biological detector and method patent-application December 2008
Guided transport of magnetically labeled biological molecules and cells patent-application June 2009
Microcoil Magnetic Resonance Detectors patent-application June 2009
Tuning Low-Inductance Coils at Low Frequencies patent-application October 2009
NMR Systems for In Vivo Detection of Analytes patent-application March 2010
System and Method for Detecting Labeled Entities Using Microcoil Magnetic MRI patent-application August 2010
Biological Detector and Method patent-application September 2010
NMR Device for Detection of Analytes patent-application January 2011
Miniaturized Magnetic Resonance Systems and Methods patent-application April 2011
NMR Systems and Methods for the Rapid Detection of Analytes patent-application April 2012
Microcoil Magnetic Resonance Detectors patent-application May 2012
Biological Detector and Method patent-application July 2013
NMR radiofrequency microcoil design: electromagnetic simulation usefulness. journal April 2002
Solenoidal and planar microcoils for NMR spectroscopy conference January 2003
Development of low field nuclear magnetic resonance microcoils journal February 2005
The signal-to-noise ratio of the nuclear magnetic resonance experiment journal October 1976
One-Step, Nanoparticle-Mediated Bacterial Detection with Magnetic Relaxation journal February 2007
Chip–NMR biosensor for detection and molecular analysis of cells journal July 2008
Miniature magnetic resonance machines journal October 1997
Planar microcoil-based magnetic resonance imaging of cells conference January 2003
Operating nanoliter scale NMR microcoils in a 1 tesla field journal September 2007
Solenoidal microcoil design. Part I: Optimizing RF homogeneity and coil dimensions journal January 2001
Miniature permanent magnet for table-top NMR journal January 2003
Design and Analysis of Microcoils for NMR Microscopy journal August 1995
RF microcoils patterned using microlithographic techniques for use as microsensors in NMR conference January 1993
Design and testing of high sensitivity microreceiver coil apparatus for nuclear magnetic resonance and imaging journal April 2001
Triaxial magnetic field gradient system for microcoil magnetic resonance imaging journal January 2000
1H NMR Detection of superparamagnetic nanoparticles at 1T using a microcoil and novel tuning circuit journal August 2006
Micro-spectrometer for NMR: analysis of small quantities in vitro journal March 2004
RF Microcoil Design for Practical NMR of Mass-Limited Samples journal July 1998
Multiparameter Magnetic Relaxation Switch Assays journal December 2007
Towards nuclear magnetic resonance μ-spectroscopy and μ-imaging journal January 2004
1H-NMR Spectroscopy on the Nanoliter Scale for Static and Online Measurements journal November 1994
High-Resolution NMR Spectroscopy of Sample Volumes from 1 nL to 10 μL journal October 1999
Self-Assembly of Ordered, Robust, Three-Dimensional Gold Nanocrystal/Silica Arrays journal April 2004
Planar microcoil-based microfluidic NMR probes journal October 2003
Viral-Induced Self-Assembly of Magnetic Nanoparticles Allows the Detection of Viral Particles in Biological Media
  • Perez, J. Manuel; Simeone, F. Joseph; Saeki, Yoshinaga
  • Journal of the American Chemical Society, Vol. 125, Issue 34, p. 10192-10193 https://doi.org/10.1021/ja036409g
journal August 2003
Microfabrication of an electromagnetic power relay using SU-8 based UV-LIGA technology journal December 2004

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