skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Biokinetic data and models for occupational intake of lanthanoids

Journal Article · · International Journal of Radiation Biology
 [1];  [2];  [3];  [3];  [4];  [5]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Atomic Energy Commission and Alternative Energies (France)
  3. Health Protection Agency of Great Britain, Didcot (United Kingdom)
  4. Intitute for Radiological Protection (IRSN), France
  5. Univ. of Cambridge (United Kingdom)

The lanthanoid (or lanthanide) chemical elements comprise fifteen elements with atomic numbers 57 (lanthanum) through 71 (lutetium). This paper reviews data related to the biological behavior of these elements in the human body and proposes biokinetic models for application to occupational intake of radio-lanthanoids. Generic (element-independent) absorption rates from the respiratory and alimentary tracts to blood are proposed. The proposed systemic models are largely generic but include some element-specific parameter values to reflect regular changes with ionic radius in certain aspects of the behavior of the lanthanoids. This work was performed within the internal dosimetry task group (INDOS) of Committee 2 of the International Commission on Radiological Protection (ICRP).

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1213982
Journal Information:
International Journal of Radiation Biology, Vol. 90, Issue 11; ISSN 0955-3002
Publisher:
Taylor and FrancisCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 20 works
Citation information provided by
Web of Science

References (39)

Localization and health effects of lanthanum chloride instilled intratracheally into rats journal November 1992
Inhalation Exposures of Beagle Dogs to Cerium Aerosols: Physical, Chemical and Mathematical Analysis journal January 1975
Solubility products of the trivalent rare-earth phosphates journal January 1991
A generic biokinetic model for predicting the behaviour of the lanthanide elements in the human body journal July 2003
Environmental variables in a holistic evaluation of land contaminated by historic mine wastes: a study of multi-element mine wastes in West Devon, England using arsenic as an element of potential concern to human health journal April 2000
Distribution of the Transuranic Elements in Mammals journal January 1962
Kinetics of Lanthanum Retention and Tissue Distribution in the Beagle Dog Following Administration of 140LaCl3 by Inhalation, Gavage and Injection journal January 1970
Lanthanides and actinides book January 1991
Distribution of Radiocerium and Radiopromethium in Mice: An autoradiographic study journal January 1964
Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides journal September 1976
Metabolism of the Lanthanons in the Rat. journal January 1956
The Uptake, Distribution and Excretion of Promethium in Humans and the Effect of DTPA on These Parameters journal January 1970
Systemic lanthanum is excreted in the bile of rats journal June 2007
Metabolic Characteristics Within a Chemical Family journal January 1959
The Metabolism of Rare Earths 1. the Distribution and Excretion of Intravenous 152-154Europium in the Rat journal January 1968
The composition of the continental crust journal April 1995
Rare-earth elements in the NBS standard reference materials spinach, orchard leaves, pine needles and bovine liver journal June 1987
Metabolism and Biological Effects of the Transplutonium Element book January 1973
Human biokinetics of inhaled terbium oxide journal August 2003
Gastrointestinal absorption of metals (51Cr, 65Zn, 95mTc, 109Cd, 113Sn, 147Pm, and 238Pu) by rats and swine journal December 1984
Critical evaluation of stability constants of metal complexes of complexones for biomedical and environmental applications* (IUPAC Technical Report) journal January 2005
Hard and Soft Acids and Bases journal November 1963
Abundance of chemical elements in the continental crust: a new table journal August 1964
Lanthanide concentrations in freshwater plants and molluscs, related to those in surface water, pore water and sediment. A case study in The Netherlands journal March 2002
The acute mammalian toxicity of rare earth nitrates and oxides journal November 1963
Lung Contamination by Ce and La Evolution of the Early Spontaneous Absorption As a Function of the Initial Lung Burden journal January 1974
Absolute Bioavailability and Disposition of Lanthanum in Healthy Human Subjects Administered Lanthanum Carbonate journal July 2006
Comparative hydrolysis behavior of the rare earths and yttrium: the influence of temperature and ionic strength journal January 2000
Effects of Gadolinium Chloride on the Rat Lung Following Intratracheal Instillation journal November 1995
Critical survey of stability constants of NTA complexes journal January 1982
Element Contents in Organs and Tissues of Chinese Adult men journal January 2010
Solubility products of the rare-earth carbonates journal January 1986
Long-term in vivo Retention of Cerium-144 by Beagles journal September 1966
Excretion of Niobium-95, Yttrium-91, Cerium-144 and Promethium-147 in Goats journal January 1961
Rare earth elements as nonabsorbable fecal markers in studies of iron absorption journal April 1997
Über die Verteilung von Radioyttrium und radioaktiven Seltenen Erden im Säugerorganismus: IV. Stoffwechseluntersuchungen mit Radiopraseodym(143Pr) an Mäusen journal October 1964
Critical survey of the stability constants of complexes of aliphatic amino acids (Technical Report) journal January 1993
Critical evaluation of the stability constants of metal complexes of amino acids with polar side chains (Technical Report) journal January 1995
Stability constants of metal complexes of amino acids with charged side chains - Part I: Positively charged side chains (Technical Report) journal January 1996

Cited By (3)

Measurement, model prediction and uncertainty quantification of plasma clearance of cerium citrate in humans journal November 2019
Updated biokinetic model for systemic americium journal May 2019
ICRP Publication 141: Occupational Intakes of Radionuclides: Part 4 journal December 2019

Similar Records

(Age-Dependent Doses to Members of the Public from Intakes of Radionuclides)
Technical Report · Wed May 01 00:00:00 EDT 1991 · OSTI ID:1213982

Effect of Dietary Intake of Stable Iodine on Dose-per-unit-intake Factors for 99Tc
Technical Report · Tue Sep 30 00:00:00 EDT 2003 · OSTI ID:1213982

Biokinetics of yttrium and comparison with its geochemical twin holmium
Journal Article · Thu Jun 01 00:00:00 EDT 2017 · Journal of Radiological Protection · OSTI ID:1213982