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Title: 24-hour human urine and serum profiles of Bisphenol A following ingestion in soup: Individual pharmacokinetic data and emographics

Journal Article · · Data in Brief
ORCiD logo [1];  [2];  [2];  [2];  [2];  [3];  [2]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Oregon State Univ., Corvallis, OR (United States)
  2. U.S. Food and Drug Administration, Jefferson, AR (United States)
  3. The Ohio State Univ., Columbus, OH (United States)
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Here we present data to evaluate potential absorption of Bisphenol A through non-metabolizing tissues of the upper digestive tract. Concurrent serum and urine concentrations of d6-BPA, and its glucuronide and sulfate conjugates, were measured over a 24 h period in 10 adult male volunteers following ingestion of 30 μg d6-BPA/kg body weight in soup. The pharmacokinetic behavior of BPA and its metabolites in this cohort (rapid absorption, complete elimination, evidence against sublingual absorption) was reported. This Data in Brief article contains the corresponding individual pharmacokinetic data, reports the demographics of the cohort and provides additional details related to the analytical methods employed and is related to [4].

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC05-76RL01830
OSTI ID:
1213564
Report Number(s):
PNNL-ACT-SA-10050; PII: S2352340915000360
Journal Information:
Data in Brief, Vol. 4, Issue C; ISSN 2352-3409
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (7)

Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats journal February 2014
Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys journal February 2013
Twenty-Four Hour Human Urine and Serum Profiles of Bisphenol A during High-Dietary Exposure journal June 2011
24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup journal October 2015
Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry
  • Twaddle, Nathan C.; Churchwell, Mona I.; Vanlandingham, Michelle
  • Rapid Communications in Mass Spectrometry, Vol. 24, Issue 20 https://doi.org/10.1002/rcm.4733
journal September 2010
Report of Very Low Real-World Exposure to Bisphenol A is Unwarranted Based on a Lack of Data and Flawed Assumptions journal October 2011
A round robin approach to the analysis of bisphenol a (BPA) in human blood samples journal April 2014

Cited By (3)

Pilot Study on the Effect of Orally Administered Bisphenol A on Glucose and Insulin Response in Nonobese Adults journal February 2019
Exposure assessment to bisphenol A (BPA) in Portuguese children by human biomonitoring journal October 2017
Rationale and design of a randomized controlled trial examining oral administration of bisphenol A on hepatic glucose production and skeletal muscle insulin sensitivity in adults journal March 2020

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES