Multirate delivery of multiple therapeutic agents from metal-organic frameworks

McKinlay, Alistair C.; Allan, Phoebe K.; Renouf, Catherine L.; Duncan, Morven J.; Wheatley, Paul S.; Warrender, Stewart J.; Dawson, Daniel; Ashbrook, Sharon E.; Gil, Barbara; Marszalek, Bartosz; Düren, Tina; Williams, Jennifer J.; Charrier, Cedric; Mercer, Derry K.; Teat, Simon J.; Morris, Russell E.

doi:10.1063/1.4903290

Title: Multirate delivery of multiple therapeutic agents from metal-organic frameworks

Journal Article · Mon Dec 01 00:00:00 EST 2014 · APL Materials

DOI:https://doi.org/10.1063/1.4903290· OSTI ID:1212664

McKinlay, Alistair C. ^[1];

^[1]; Renouf, Catherine L. ^[1]; Duncan, Morven J. ^[1]; Wheatley, Paul S. ^[1]; Warrender, Stewart J. ^[1];

^[1]; Ashbrook, Sharon E. ^[1]; Gil, Barbara ^[2]; Marszalek, Bartosz ^[2]; Düren, Tina ^[3]; Williams, Jennifer J. ^[3];

^[4];

^[4]; Teat, Simon J. ^[5]; Morris, Russell E. ^[1]

Univ. of St. Andrews, St. Andrews (United Kingdom)
Jagiellonian Univ., Krakow (Poland)
The Univ. of Edinburgh, Edinburgh (United Kingdom)
NovaBiotics Ltd., Aberdeen (United Kingdom)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1212664

Journal Information:: APL Materials, Vol. 2, Issue 12; ISSN 2166-532X

Publisher:: American Institute of Physics (AIP)Copyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 48 works

Citation information provided by
Web of Science

References (33)

The pervasive chemistry of metal–organic frameworks Long, Jeffrey R.; Yaghi, Omar M. Chemical Society Reviews, Vol. 38, Issue 5, p. 1213-1214 https://doi.org/10.1039/b903811f	journal	January 2009
Hydrogen Storage in Microporous Metal-Organic Frameworks Rosi, Nathaniel L.; Eckert, Juergen; Eddaoudi, Mohamed Science, Vol. 300, Issue 5622, p. 1127-1129 https://doi.org/10.1126/science.1083440	journal	May 2003
Systematic Design of Pore Size and Functionality in Isoreticular MOFs and Their Application in Methane Storage Eddaoudi, Mohamed; Kim, Jaheon; Rosi, Nathaniel Science, Vol. 295, Issue 5554, p. 469-472 https://doi.org/10.1126/science.1067208	journal	January 2002
Colossal cages in zeolitic imidazolate frameworks as selective carbon dioxide reservoirs Wang, Bo; Côté, Adrien P.; Furukawa, Hiroyasu Nature, Vol. 453, Issue 7192, p. 207-211 https://doi.org/10.1038/nature06900	journal	May 2008
Role of Solvent-Host Interactions That Lead to Very Large Swelling of Hybrid Frameworks Serre, C.; Mellot-Draznieks, C.; Surble, S. Science, Vol. 315, Issue 5820 https://doi.org/10.1126/science.1137975	journal	March 2007
Chemically blockable transformation and ultraselective low-pressure gas adsorption in a non-porous metal organic framework Xiao, Bo; Byrne, Peter J.; Wheatley, Paul S. Nature Chemistry, Vol. 1, Issue 4 https://doi.org/10.1038/nchem.254	journal	June 2009
Protecting group and switchable pore-discriminating adsorption properties of a hydrophilic–hydrophobic metal–organic framework Mohideen, M. Infas H.; Xiao, Bo; Wheatley, Paul S. Nature Chemistry, Vol. 3, Issue 4 https://doi.org/10.1038/nchem.1003	journal	March 2011
Metal–Organic Frameworks in Biomedicine Horcajada, Patricia; Gref, Ruxandra; Baati, Tarek Chemical Reviews, Vol. 112, Issue 2, p. 1232-1268 https://doi.org/10.1021/cr200256v	journal	September 2011
BioMOFs: Metal-Organic Frameworks for Biological and Medical Applications McKinlay, Alistair C.; Morris, Russell E.; Horcajada, Patricia Angewandte Chemie International Edition, Vol. 49, Issue 36, p. 6260-6266 https://doi.org/10.1002/anie.201000048	journal	July 2010
Nanoscale Metal–Organic Frameworks for Biomedical Imaging and Drug Delivery Della Rocca, Joseph; Liu, Demin; Lin, Wenbin Accounts of Chemical Research, Vol. 44, Issue 10, p. 957-968 https://doi.org/10.1021/ar200028a	journal	October 2011
Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging Horcajada, Patricia; Chalati, Tamim; Serre, Christian Nature Materials, Vol. 9, Issue 2 https://doi.org/10.1038/nmat2608	journal	December 2009
Exceptional Behavior over the Whole Adsorption−Storage−Delivery Cycle for NO in Porous Metal Organic Frameworks McKinlay, Alistair C.; Xiao, Bo; Wragg, David S. Journal of the American Chemical Society, Vol. 130, Issue 31 https://doi.org/10.1021/ja801997r	journal	August 2008
Metal–organic frameworks as potential multi-carriers of drugs Rojas, Sara; Wheatley, Paul S.; Quartapelle-Procopio, Elsa CrystEngComm, Vol. 15, Issue 45 https://doi.org/10.1039/c3ce41289j	journal	January 2013
Mechanisms of drug combinations: interaction and network perspectives Jia, Jia; Zhu, Feng; Ma, Xiaohua Nature Reviews Drug Discovery, Vol. 8, Issue 2 https://doi.org/10.1038/nrd2683	journal	February 2009
An In Situ High-Temperature Single-Crystal Investigation of a Dehydrated Metal-Organic Framework Compound and Field-Induced Magnetization of One-Dimensional Metal-Oxygen Chains Dietzel, Pascal D. C.; Morita, Yusuke; Blom, Richard Angewandte Chemie International Edition, Vol. 44, Issue 39, p. 6354-6358 https://doi.org/10.1002/anie.200501508	journal	October 2005
Rod Packings and Metal−Organic Frameworks Constructed from Rod-Shaped Secondary Building Units Rosi, Nathaniel L.; Kim, Jaheon; Eddaoudi, Mohamed Journal of the American Chemical Society, Vol. 127, Issue 5, p. 1504-1518 https://doi.org/10.1021/ja045123o	journal	February 2005
A Chemically Functionalizable Nanoporous Material [Cu₃(TMA)₂(H₂O)₃]_n Chui, Stephen S.-Y.; Lo, Samuel M.-F.; Charmant, Jonathan P. H. Science, Vol. 283, Issue 5405, p. 1148-1150 https://doi.org/10.1126/science.283.5405.1148	journal	February 1999
High-Capacity Hydrogen and Nitric Oxide Adsorption and Storage in a Metal−Organic Framework Xiao, Bo; Wheatley, Paul S.; Zhao, Xuebo Journal of the American Chemical Society, Vol. 129, Issue 5 https://doi.org/10.1021/ja066098k	journal	February 2007
Hydrocarbon Separations in a Metal-Organic Framework with Open Iron(II) Coordination Sites Bloch, E. D.; Queen, W. L.; Krishna, R. Science, Vol. 335, Issue 6076, p. 1606-1610 https://doi.org/10.1126/science.1217544	journal	March 2012
Highly efficient separation of carbon dioxide by a metal-organic framework replete with open metal sites Britt, D.; Furukawa, H.; Wang, B. Proceedings of the National Academy of Sciences, Vol. 106, Issue 49, p. 20637-20640 https://doi.org/10.1073/pnas.0909718106	journal	November 2009
Silver carboxylate metal–organic frameworks with highly antibacterial activity and biocompatibility Lu, Xinyi; Ye, Junwei; Zhang, Dekui Journal of Inorganic Biochemistry, Vol. 138 https://doi.org/10.1016/j.jinorgbio.2014.05.005	journal	September 2014
Flexible Porous Metal-Organic Frameworks for a Controlled Drug Delivery Horcajada, Patricia; Serre, Christian; Maurin, Guillaume Journal of the American Chemical Society, Vol. 130, Issue 21 https://doi.org/10.1021/ja710973k	journal	May 2008
Metal–Organic Frameworks as Efficient Materials for Drug Delivery Horcajada, Patricia; Serre, Christian; Vallet-Regí, María Angewandte Chemie International Edition, Vol. 45, Issue 36, p. 5974-5978 https://doi.org/10.1002/anie.200601878	journal	September 2006
Metal–organic frameworks as potential drug carriers Huxford, Rachel C.; Della Rocca, Joseph; Lin, Wenbin Current Opinion in Chemical Biology, Vol. 14, Issue 2 https://doi.org/10.1016/j.cbpa.2009.12.012	journal	April 2010
Metal organic frameworks as NO delivery materials for biological applications Hinks, Nathan J.; McKinlay, Alistair C.; Xiao, Bo Microporous and Mesoporous Materials, Vol. 129, Issue 3 https://doi.org/10.1016/j.micromeso.2009.04.031	journal	April 2010
Metal–organic frameworks for the storage and delivery of biologically active hydrogen sulfide Allan, Phoebe K.; Wheatley, Paul S.; Aldous, David Dalton Transactions, Vol. 41, Issue 14 https://doi.org/10.1039/c2dt12069k	journal	January 2012
Base-Induced Formation of Two Magnesium Metal-Organic Framework Compounds with a Bifunctional Tetratopic Ligand Dietzel, Pascal D. C.; Blom, Richard; Fjellvåg, Helmer European Journal of Inorganic Chemistry, Vol. 2008, Issue 23 https://doi.org/10.1002/ejic.200701284	journal	August 2008
Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America Boucher, Helen W.; Talbot, George H.; Bradley, John S. Clinical Infectious Diseases, Vol. 48, Issue 1 https://doi.org/10.1086/595011	journal	January 2009
Topically Applied Nitric Oxide Induces T-Lymphocyte Infiltration in Human Skin, but Minimal Inflammation Mowbray, Megan; Tan, Xuejing; Wheatley, Paul S. Journal of Investigative Dermatology, Vol. 128, Issue 2 https://doi.org/10.1038/sj.jid.5701096	journal	February 2008
An In Situ High-Temperature Single-Crystal Investigation of a Dehydrated Metal-Organic Framework Compound and Field-Induced Magnetization of One-Dimensional Metal-Oxygen Chains Dietzel, Pascal D. C.; Morita, Yusuke; Blom, Richard Angewandte Chemie, Vol. 117, Issue 39 https://doi.org/10.1002/ange.200501508	journal	October 2005
Metal–organic frameworks as potential drug carriers Wenbin, Lin,; Joseph, Della Rocca,; C., Huxford, Rachel The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/5zda-3z17	text	January 2010
Nanoscale Metal–Organic Frameworks for Biomedical Imaging and Drug Delivery Wenbin, Lin,; Joseph, Della Rocca,; Demin, Liu, The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/q7c0-kf53	text	January 2011
Metal–Organic Frameworks as Efficient Materials for Drug Delivery Horcajada, Patricia; Serre, Christian; Vallet-Regí, María Angewandte Chemie, Vol. 118, Issue 36 https://doi.org/10.1002/ange.200601878	journal	September 2006

Cited By (15)

Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications Wuttke, Stefan; Zimpel, Andreas; Bein, Thomas Advanced Healthcare Materials, Vol. 6, Issue 2 https://doi.org/10.1002/adhm.201600818	journal	November 2016
Synergistic Antimicrobial Activity in Ampicillin Loaded Core‐Shell ZnO@ZIF‐8 Particles Mohanta, Girish C.; Pandey, Satish K.; Maurya, Indresh K. ChemistrySelect, Vol. 4, Issue 41 https://doi.org/10.1002/slct.201902379	journal	November 2019
Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000 Wang, Timothy C.; Vermeulen, Nicolaas A.; Kim, In Soo Nature Protocols, Vol. 11, Issue 1 https://doi.org/10.1038/nprot.2016.001	journal	December 2015
MOF nanoparticles coated by lipid bilayers and their uptake by cancer cells Wuttke, Stefan; Braig, Simone; Preiß, Tobias Chemical Communications, Vol. 51, Issue 87 https://doi.org/10.1039/c5cc06767g	journal	January 2015
Coordination polymers of 5-substituted isophthalic acid McCormick, Laura J.; Morris, Samuel A.; Slawin, Alexandra M. Z. CrystEngComm, Vol. 18, Issue 7 https://doi.org/10.1039/c5ce02091c	journal	January 2016
A novel zinc( ii ) metal–organic framework with a diamond-like structure: synthesis, study of thermal robustness and gas adsorption properties Almáši, Miroslav; Zeleňák, Vladimír; Zukal, Arnošt Dalton Transactions, Vol. 45, Issue 3 https://doi.org/10.1039/c5dt02437d	journal	January 2016
Biocompatible polymer–metal–organic framework composite patches for cutaneous administration of cosmetic molecules Márquez, Alfonso García; Hidalgo, Tania; Lana, Hugo Journal of Materials Chemistry B, Vol. 4, Issue 43 https://doi.org/10.1039/c6tb01652a	journal	January 2016
Metal organic frameworks based on bioactive components Rojas, S.; Devic, T.; Horcajada, P. Journal of Materials Chemistry B, Vol. 5, Issue 14 https://doi.org/10.1039/c6tb03217f	journal	January 2017
A tumor treatment strategy based on biodegradable BSA@ZIF-8 for simultaneously ablating tumors and inhibiting infection Wu, Qiong; Li, Mei; Tan, Longfei Nanoscale Horizons, Vol. 3, Issue 6 https://doi.org/10.1039/c8nh00113h	journal	January 2018
An “all-in-one” antitumor and anti-recurrence/metastasis nanomedicine with multi-drug co-loading and burst drug release for multi-modality therapy Yang, Ji-Chun; Shang, Yue; Li, Yu-Hao Chemical Science, Vol. 9, Issue 36 https://doi.org/10.1039/c8sc02305k	journal	January 2018
Bioactive nano-metal–organic frameworks as antimicrobials against Gram-positive and Gram-negative bacteria Bhardwaj, Neha; Pandey, Satish K.; Mehta, Jyotsana Toxicology Research, Vol. 7, Issue 5 https://doi.org/10.1039/c8tx00087e	journal	January 2018
A single crystal study of CPO-27 and UTSA-74 for nitric oxide storage and release Henkelis, Susan E.; Vornholt, Simon M.; Cordes, David B. CrystEngComm, Vol. 21, Issue 12 https://doi.org/10.1039/c9ce00098d	journal	January 2019
Synthesis and structural characterisation of the copper MOF: STAM-NMe ₂ McHugh, Lauren N.; Olivera Perez, Leonardo J.; Wheatley, Paul S. CrystEngComm, Vol. 21, Issue 36 https://doi.org/10.1039/c9ce01035a	journal	January 2019
Antibacterial applications of metal–organic frameworks and their composites Shen, Mofei; Forghani, Fereidoun; Kong, Xueqian Comprehensive Reviews in Food Science and Food Safety, Vol. 19, Issue 4 https://doi.org/10.1111/1541-4337.12515	journal	January 2020
Liposome-Coated Iron Fumarate Metal-Organic Framework Nanoparticles for Combination Therapy Illes, Bernhard; Wuttke, Stefan; Engelke, Hanna Nanomaterials, Vol. 7, Issue 11 https://doi.org/10.3390/nano7110351	journal	October 2017

Similar Records

Olsalazine-Based Metal–Organic Frameworks as Biocompatible Platforms for H ₂ Adsorption and Drug Delivery

Journal Article · Wed Aug 17 00:00:00 EDT 2016 · Journal of the American Chemical Society · OSTI ID:1212664

Levine, Dana J.; Runčevski, Tomče; Kapelewski, Matthew T.; +9 more

Protection against Chemical Warfare Agents and Biological Threats Using Metal–Organic Frameworks as Active Layers

Journal Article · Sat Jan 07 00:00:00 EST 2023 · Accounts of Materials Research · OSTI ID:1212664

Ma, Kaikai; Cheung, Yuk Ha; Kirlikovali, Kent O.; +4 more

Biomedical Integration of Metal–Organic Frameworks

Journal Article · Wed Apr 22 00:00:00 EDT 2020 · Trends in Chemistry · OSTI ID:1212664

Banerjee, Sayan; Lollar, Christina T.; Xiao, Zhifeng; +2 more

Related Subjects

60 APPLIED LIFE SCIENCES
36 MATERIALS SCIENCE
drug delivery
microstructured fibers
bacteria
materials properties
nickel

Title: Multirate delivery of multiple therapeutic agents from metal-organic frameworks

Citation Formats

References (33)

Cited By (15)

Similar Records

Related Subjects