Nano-gold corking and enzymatic uncorking of carbon nanotube cups

Zhao, Yong; Burkert, Seth C.; Tang, Yifan; Sorescu, Dan C.; Kapralov, Alexandr A.; Shurin, Galina V.; Shurin, Michael R.; Kagan, Valerian E.; Star, Alexander

doi:10.1021/ja511843w

Title: Nano-gold corking and enzymatic uncorking of carbon nanotube cups

Journal Article · Sun Dec 21 00:00:00 EST 2014 · Journal of the American Chemical Society

DOI:https://doi.org/10.1021/ja511843w· OSTI ID:1186638

Zhao, Yong ^[1]; Burkert, Seth C. ^[1]; Tang, Yifan ^[1]; Sorescu, Dan C. ^[2]; Kapralov, Alexandr A. ^[1]; Shurin, Galina V. ^[3]; Shurin, Michael R. ^[3]; Kagan, Valerian E. ^[1]; Star, Alexander ^[1]

Univ. of Pittsburgh, Pittsburgh, PA (United States)
National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States)
Univ. of Pittsburgh Medical Center, Pittsburgh, PA (United States)

Because of their unique stacked, cup-shaped, hollow compartments, nitrogen-doped carbon nanotube cups (NCNCs) have promising potential as nanoscale containers. Individual NCNCs are isolated from their stacked structure through acid oxidation and subsequent probe-tip sonication. The NCNCs are then effectively corked with gold nanoparticles (GNPs) by sodium citrate reduction with chloroauric acid, forming graphitic nanocapsules with significant surface-enhanced Raman signature. Mechanistically, the growth of the GNP corks starts from the nucleation and welding of gold seeds on the open rims of NCNCs enriched with nitrogen functionalities, as confirmed by density functional theory calculations. A potent oxidizing enzyme of neutrophils, myeloperoxidase (MPO), can effectively open the corked NCNCs through GNP detachment, with subsequent complete enzymatic degradation of the graphitic shells. Lastly, this controlled opening and degradation was further carried out in vitro with human neutrophils. In addition, the GNP-corked NCNCs were demonstrated to function as novel drug delivery carriers, capable of effective (i) delivery of paclitaxel to tumor-associated myeloid-derived suppressor cells (MDSC), (ii) MPO-regulated release, and (iii) blockade of MDSC immunosuppressive potential.

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Research Organization:: National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: 0954345; R01CA154369; R01ES019304; NIOSH OH008282; HL114453; U19 AI068021

OSTI ID:: 1186638

Report Number(s):: A-UNIV-PUB-122

Journal Information:: Journal of the American Chemical Society, Vol. 137, Issue 2; ISSN 0002-7863

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 32 works

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