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Title: The tmRNA website

Journal Article · · Nucleic Acids Research
DOI:https://doi.org/10.1093/nar/gku1109· OSTI ID:1183117
 [1];  [1]
  1. Sandia National Lab. (SNL-CA), Livermore, CA (United States)

We report that the transfer-messenger RNA (tmRNA) and its partner protein SmpB act together in resolving problems arising when translating bacterial ribosomes reach the end of mRNA with no stop codon. Their genes have been found in nearly all bacterial genomes and in some organelles. The tmRNA Website serves tmRNA sequences, alignments and feature annotations, and has recently moved to http: //bioinformatics.sandia.gov/tmrna/. New features include software used to find the sequences, an update raising the number of unique tmRNA sequences from 492 to 1716, and a database of SmpB sequences which are served along with the tmRNA sequence from the same organism.

Research Organization:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA)
Grant/Contract Number:
AC04-94AL85000
OSTI ID:
1183117
Report Number(s):
SAND2014-17264J; 537177
Journal Information:
Nucleic Acids Research, Vol. 43, Issue D1; ISSN 0305-1048
Publisher:
Oxford University PressCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 22 works
Citation information provided by
Web of Science

References (35)

Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA journal February 1996
Protein factors associated with the SsrA*SmpB tagging and ribosome rescue complex journal February 2001
Structural basis for functional mimicry of long-variable-arm tRNA by transfer-messenger RNA journal May 2007
Decoding in the Absence of a Codon by tmRNA and SmpB in the Ribosome journal March 2012
Ends of the line for tmRNA-SmpB journal August 2014
tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence journal March 1997
ARAGORN, a program to detect tRNA genes and tmRNA genes in nucleotide sequences journal January 2004
RefSeq microbial genomes database: new representation and annotation strategy journal December 2013
tmRNAs that encode proteolysis-inducing tags are found in all known bacterial genomes: A two-piece tmRNA functions in Caulobacter journal July 2000
RNAcentral: A vision for an international database of RNA sequences journal September 2011
The International Nucleotide Sequence Database Collaboration journal November 2012
Pfam: the protein families database journal November 2013
CDD: conserved domains and protein three-dimensional structure journal November 2012
Interactive metagenomic visualization in a Web browser journal September 2011
The tmRDB and SRPDB resources journal January 2006
Rfam 11.0: 10 years of RNA families journal November 2012
The tmRNA website: reductive evolution of tmRNA in plastids and other endosymbionts journal January 2004
RefSeq microbial genomes database: new representation and annotation strategy journal March 2015
DNA extraction approaches substantially influence the assessment of the human breast milk microbiome journal January 2020
Database resources of the National Center for Biotechnology Information journal January 2006
The international nucleotide sequence database collaboration journal November 2017
A nickel complex cleaves uridine in folded RNA structures: application to E. coli tmRNA and related engineered molecules journal June 1998
A phylogenetic analysis of the cytochrome b and cytochrome c oxidase I genes supports an origin of mitochondria from within the Rickettsiaceae1The nucleotide sequences in this paper have been deposited in the EMBL sequence database under accession Nos. Y13854 (cob) and Y13855 (cox1).1 journal July 1998
A tRNA-like structure is present in 10Sa RNA, a small stable RNA from Escherichia coli. journal September 1994
C-terminal Extension of Truncated Recombinant Proteins in Escherichia coli with a 10Sa RNA Decapeptide journal April 1995
tRNA-like structures in 10Sa RNAs of Mycoplasma capricolum and Bacillus subtilis journal January 1994
The RDP (Ribosomal Database Project) journal January 1997
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs journal September 1997
Database resources of the National Center for Biotechnology Information journal October 2020
The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system journal May 1998
Database resources of the National Center for Biotechnology Information journal December 2007
The International Nucleotide Sequence Database Collaboration journal November 2011
Database resources of the National Center for Biotechnology Information journal November 2018
The International Nucleotide Sequence Database Collaboration journal December 2015
When Proteins Receive Deadly Messages at Birth journal February 1996

Cited By (11)

PPI-Detect: A support vector machine model for sequence-based prediction of protein-protein interactions: PPI-Detect: A Support Vector Machine Model for Sequence-Based Prediction of Protein-Protein Interactions journal February 2019
Structures of Mycobacterium smegmatis 70S ribosomes in complex with HPF, tmRNA, and P-tRNA journal September 2018
Ribosome pausing, arrest and rescue in bacteria and eukaryotes journal March 2017
Comparing miRNA structure of mirtrons and non-mirtrons journal February 2018
A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites journal February 2019
Requirement of transfer-messenger RNA for the growth of Bacillus subtilis under stresses: Physiological role of B. subtilis tmRNA journal August 2000
tmRNAs that encode proteolysis-inducing tags are found in all known bacterial genomes: A two-piece tmRNA functions in Caulobacter journal July 2000
Comparing miRNA structure of mirtrons and non-mirtrons journal November 2017
A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites journal August 2018
Evaluation of a novel real-time PCR test based on the ssrAgene for the identification of group B streptococci in vaginal swabs journal September 2009
A semi-supervised machine learning framework for microRNA classification journal October 2019

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