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Title: Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation

Journal Article · · Metallomics
DOI:https://doi.org/10.1039/C5MT00023H· OSTI ID:1182302
 [1];  [1];  [2];  [1]
  1. Purdue Univ., West Lafayette, IN (United States). Dept. of Physics and Astronomy
  2. Purdue Univ., West Lafayette, IN (United States). School of Health Sciences

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
USDOE Office of Science (SC); National Institutes of Health (NIH)
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1182302
Journal Information:
Metallomics, Vol. 7, Issue 5; ISSN 1756-5901
Publisher:
Royal Society of ChemistryCopyright Statement
Country of Publication:
United States
Language:
ENGLISH
Citation Metrics:
Cited by: 26 works
Citation information provided by
Web of Science

References (51)

Manganese toxicity upon overexposure journal November 2004
Manganese-induced parkinsonism in methcathinone abusers: bio-markers of exposure and follow-up journal January 2013
Chronic Parkinsonism Associated With Cirrhosis: A Distinct Subset of Acquired Hepatocerebral Degeneration journal April 2003
Relationship Between Changes in Brain MRI and 1 H-MRS, Severity of Chronic Liver Damage, and Recovery After Liver Transplantation journal September 2009
Manganese and Parkinson’s Disease: A Critical Review and New Findings journal August 2010
Manganese-Induced Parkinsonism and Parkinson's Disease journal March 2004
Are There Common Biochemical and Molecular Mechanisms Controlling Manganism and Parkisonism journal September 2009
A study of the relationships between Parkinson's disease and markers of traffic-derived and environmental manganese air pollution in two Canadian cities journal July 2007
Multiple risk factors for Parkinson's disease journal February 2004
High prevalence of parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries journal January 2007
Employment as a Welder and Parkinson Disease Among Heavy Equipment Manufacturing Workers journal January 2006
Welding-related parkinsonism: Clinical features, treatment, and pathophysiology journal January 2001
State-of-the-Science Review: Does Manganese Exposure During Welding Pose a Neurological Risk? journal August 2007
Parkin attenuates manganese-induced dopaminergic cell death: Parkin in Mn-induced dopaminergic cell death journal May 2004
α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity journal February 2009
Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes journal December 2010
Epidemiology and etiology of Parkinson’s disease: a review of the evidence journal May 2011
Manganese Accumulates within Golgi Apparatus in Dopaminergic Cells as Revealed by Synchrotron X-ray Fluorescence Nanoimaging journal December 2009
Environmental manganese compounds accumulate as Mn(ii) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity journal January 2014
X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons journal December 2012
Manganese accumulates primarily in nuclei of cultured brain cells journal May 2008
Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia journal July 2009
Visualizing manganese in the primate basal ganglia with magnetic resonance imaging journal December 1989
MRI and PET studies of manganese-intoxicated monkeys journal June 1995
Manganese enhanced MRI in rat hippocampus: A correlative study with synchrotron X-ray microprobe journal January 2013
X-Ray Fluorescence Imaging: A New Tool for Studying Manganese Neurotoxicity journal November 2012
X-ray fluorescence imaging of the hippocampal formation after manganese exposure journal January 2013
Ventral mesencephalic neurons containing both cholecystokinin- and tyrosine hydroxylase-like immunoreactivities project to forebrain regions journal January 1989
Microarray analysis of fluoro-gold labeled rat dopamine neurons harvested by laser capture microdissection journal April 2005
Zinc in DNA Replication and Transcription journal July 1987
Alteration of iron homeostasis following chronic exposure to manganese in rats1Published on the World Wide Web on 10 May 1999.1 journal June 1999
Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague–Dawley rats journal March 2009
Manganese intoxication and chronic liver failure journal December 1994
Inhibition of DAT function attenuates manganese accumulation in the globus pallidus journal March 2007
Considerations on manganese (Mn) treatments for in vitro studies journal March 2014
The clearance of manganese chloride in the primate journal August 1987
Biological half-lives of zinc and manganese in rat brain journal October 1995
Pharmacokinetics of Inhaled Manganese Phosphate in Male Sprague–Dawley Rats Following Subacute (14-Day) Exposure journal March 2000
Hepatic subcellular distribution of manganese in manganese and manganese-bilirubin induced cholestasis journal November 1985
Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats journal January 2008
β-Cell subcellular localization of glucose-stimulated Mn uptake by X-ray fluorescence microscopy: implications for pancreatic MRI: β-CELL SUBCELLULAR LOCALIZATION OF MANGANESE UPTAKE BY XFM journal November 2011
Effects of Manganese on Extracellular Levels of Dopamine in Rat Striatum: An Analysis In vivo by Brain Microdialysis journal September 2005
Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism journal December 2008
Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates journal December 2006
Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes journal June 2008
Manganese mixture inhalation is a reliable Parkinson disease model in rats journal October 2012
Enhancing Effect of Manganese on L-DOPA-Induced Apoptosis in PC12 Cells: Role of Oxidative Stress journal September 1999
Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: potential implications to L-DOPA long-term therapy of Parkinson's disease: Manganese and L-DOPA auto-oxidation in vivo journal June 2000
Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans journal August 2010
Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra journal November 1997
Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter journal November 2005

Cited By (6)

GLAST Activity is Modified by Acute Manganese Exposure in Bergmann Glial Cells journal July 2019
“Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies” journal November 2016
Metals and Neurodegeneration journal January 2016
Mapping Chemical Elements and Iron Oxidation States in the Substantia Nigra of 6-Hydroxydopamine Lesioned Rats Using Correlative Immunohistochemistry With Proton and Synchrotron Micro-Analysis journal September 2019
Metals and Neurodegeneration book January 2012
Metals and neurodegeneration journal September 2015