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Title: Purine inhibitors of protein kinases, G proteins and polymerases

Patent ·
OSTI ID:1175071

The present invention relates to 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.

Research Organization:
Univ. of California, Oakland, CA (United States); Centre National de la Recherche (France)
Sponsoring Organization:
USDOE
Assignee:
The Regents of the University of California (Oakland, CA); Centre National de la Recherche (FR)
Patent Number(s):
6,803,371
Application Number:
10/352,752
OSTI ID:
1175071
Country of Publication:
United States
Language:
English

References (7)

Combinatorial synthesis of 2,9-substituted purines journal February 1997
Inhibition of Cyclin-Dependent Kinases by Purine Analogues journal September 1994
Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors:  Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds journal February 1997
A Structure-Based Library Approach to Kinase Inhibitors journal January 1996
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors journal June 1999
Synthesis and activity of 2,6,9-trisubstituted purines journal November 1997
Inhibition of Cyclin-Dependent Kinases by Purine Analogues. Crystal Structure of Human cdk2 Complexed with Roscovitine journal January 1997