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Title: Self assembling proteins

Patent ·
OSTI ID:1174921

Novel fusion proteins capable of self-assembling into regular structures, as well as nucleic acids encoding the same, are provided. The subject fusion proteins comprise at least two oligomerization domains rigidly linked together, e.g. through an alpha helical linking group. Also provided are regular structures comprising a plurality of self-assembled fusion proteins of the subject invention, and methods for producing the same. The subject fusion proteins find use in the preparation of a variety of nanostructures, where such structures include: cages, shells, double-layer rings, two-dimensional layers, three-dimensional crystals, filaments, and tubes.

Research Organization:
Univ. of California, Oakland, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FGO3-87ER60615
Assignee:
University Of California, The Regents Of
Patent Number(s):
6,756,039
Application Number:
09/564,710
OSTI ID:
1174921
Country of Publication:
United States
Language:
English

References (11)

A Chemically Functionalizable Nanoporous Material [Cu3(TMA)2(H2O)3]n journal February 1999
Why protein crystals favour some space-groups over others journal December 1995
Fullerenes and carbon nanotubes journal April 1996
Supertetrahedral Sulfide Crystals with Giant Cavities and Channels journal February 1999
Nanometre-size tubes of carbon journal October 1997
DNA engineering and its application to nanotechnology journal November 1999
Nanocrystal Superlattices journal October 1998
Self-assembling organic nanotubes based on a cyclic peptide architecture journal December 1993
The stability of the fullerenes Cn, with n = 24, 28, 32, 36, 50, 60 and 70 journal October 1987
Helical microtubules of graphitic carbon journal November 1991
Self-organizing molecular networks journal May 1998

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