Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate
A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.
- Research Organization:
- Univ. of Illinois at Urbana-Champaign, IL (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-08ER64682
- Assignee:
- The Board of Trustees of the University of Illinois (Urbana, IL)
- Patent Number(s):
- 8,980,185
- Application Number:
- 13/818,569
- OSTI ID:
- 1172760
- Resource Relation:
- Patent File Date: 2011 Aug 25
- Country of Publication:
- United States
- Language:
- English
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