pH and Amphiphilic Structure Direct Supramolecular Behavior in Biofunctional Assemblies
Abstract
Supramolecular self-assembly offers promising new ways to control nanostructure morphology and respond to external stimuli. A pH-sensitive self-assembled system was developed to both control nanostructure shape and respond to the acidic microenvironment of tumors using self-assembling peptide amphiphiles (PAs). Here, by incorporating an oligo-histidine H6 sequence, we developed two PAs that self-assembled into distinct morphologies on the nanoscale, either as nanofibers or spherical micelles, based on the incorporation of the aliphatic tail on the N-terminus or near the C-terminus, respectively. Both cylinder and sphere-forming PAs demonstrated reversible disassembly between pH 6.0 and 6.5 upon protonation of the histidine residues in acidic solutions. These PAs were then characterized and assessed for their potential to encapsulate hydrophobic chemotherapies. The H6-based nanofiber assemblies encapsulated camptothecin (CPT) with up to 60% efficiency, a 7-fold increase in CPT encapsulation relative to spherical micelles. Additionally, pH-sensitive nanofibers showed improved tumor accumulation over both spherical micelles and nanofibers that did not change morphologies in acidic environments. We have demonstrated that the morphological transitions upon changes in pH of supramolecular nanostructures affect drug encapsulation and tumor accumulation. Lastly, our findings also suggest that these supramolecular events can be tuned by molecular design to improve the pharmacologic properties ofmore »
- Authors:
-
- Northwestern Univ., Chicago, IL (United States). Inst. for BioNanotechnology in Medicine, Dept. of Materials Science and Engineering
- Northwestern Univ., Chicago, IL (United States). Inst. for BioNanotechnology in Medicine; Northwestern Univ., Evanston, IL (United States). Dept. of Chemistry
- Northwestern Univ., Chicago, IL (United States). Inst. for BioNanotechnology in Medicine; Northwestern Univ., Chicago, IL (United States). Feinberg School of Medicine, Dept. of Medicine
- Northwestern Univ., Chicago, IL (United States). Feinberg School of Medicine, Dept. of Medicine
- Univ. of Wisconsin, Madison, WI (United States). School of Medicine and Public Health, Carbone Cancer Center and Dept. of Medicine
- Northwestern Univ., Chicago, IL (United States). Inst. for BioNanotechnology in Medicine, Dept. of Materials Science and Engineering; Northwestern Univ., Evanston, IL (United States). Dept. of Chemistry; Northwestern Univ., Chicago, IL (United States). Feinberg School of Medicine, Dept. of Medicine
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Institutes of Health (NIH); Department of Defense (DoD)
- OSTI Identifier:
- 1165620
- Grant/Contract Number:
- AC02-06CH11357; 5U54CA151880-03; 5R01DE015920-09; W81XWH-10-1-0503
- Resource Type:
- Journal Article: Accepted Manuscript
- Journal Name:
- Journal of the American Chemical Society
- Additional Journal Information:
- Journal Volume: 136; Journal Issue: 42; Journal ID: ISSN 0002-7863
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- ENGLISH
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES
Citation Formats
Moyer, Tyson J., Finbloom, Joel A., Chen, Feng, Toft, Daniel J., Cryns, Vincent L., and Stupp, Samuel I. pH and Amphiphilic Structure Direct Supramolecular Behavior in Biofunctional Assemblies. United States: N. p., 2014.
Web. doi:10.1021/ja5042429.
Moyer, Tyson J., Finbloom, Joel A., Chen, Feng, Toft, Daniel J., Cryns, Vincent L., & Stupp, Samuel I. pH and Amphiphilic Structure Direct Supramolecular Behavior in Biofunctional Assemblies. United States. https://doi.org/10.1021/ja5042429
Moyer, Tyson J., Finbloom, Joel A., Chen, Feng, Toft, Daniel J., Cryns, Vincent L., and Stupp, Samuel I. 2014.
"pH and Amphiphilic Structure Direct Supramolecular Behavior in Biofunctional Assemblies". United States. https://doi.org/10.1021/ja5042429. https://www.osti.gov/servlets/purl/1165620.
@article{osti_1165620,
title = {pH and Amphiphilic Structure Direct Supramolecular Behavior in Biofunctional Assemblies},
author = {Moyer, Tyson J. and Finbloom, Joel A. and Chen, Feng and Toft, Daniel J. and Cryns, Vincent L. and Stupp, Samuel I.},
abstractNote = {Supramolecular self-assembly offers promising new ways to control nanostructure morphology and respond to external stimuli. A pH-sensitive self-assembled system was developed to both control nanostructure shape and respond to the acidic microenvironment of tumors using self-assembling peptide amphiphiles (PAs). Here, by incorporating an oligo-histidine H6 sequence, we developed two PAs that self-assembled into distinct morphologies on the nanoscale, either as nanofibers or spherical micelles, based on the incorporation of the aliphatic tail on the N-terminus or near the C-terminus, respectively. Both cylinder and sphere-forming PAs demonstrated reversible disassembly between pH 6.0 and 6.5 upon protonation of the histidine residues in acidic solutions. These PAs were then characterized and assessed for their potential to encapsulate hydrophobic chemotherapies. The H6-based nanofiber assemblies encapsulated camptothecin (CPT) with up to 60% efficiency, a 7-fold increase in CPT encapsulation relative to spherical micelles. Additionally, pH-sensitive nanofibers showed improved tumor accumulation over both spherical micelles and nanofibers that did not change morphologies in acidic environments. We have demonstrated that the morphological transitions upon changes in pH of supramolecular nanostructures affect drug encapsulation and tumor accumulation. Lastly, our findings also suggest that these supramolecular events can be tuned by molecular design to improve the pharmacologic properties of nanomedicines.},
doi = {10.1021/ja5042429},
url = {https://www.osti.gov/biblio/1165620},
journal = {Journal of the American Chemical Society},
issn = {0002-7863},
number = 42,
volume = 136,
place = {United States},
year = {Mon Oct 13 00:00:00 EDT 2014},
month = {Mon Oct 13 00:00:00 EDT 2014}
}
Web of Science
Works referenced in this record:
Nanocarriers as an emerging platform for cancer therapy
journal, December 2007
- Peer, Dan; Karp, Jeffrey M.; Hong, Seungpyo
- Nature Nanotechnology, Vol. 2, Issue 12
Nanoparticle therapeutics: an emerging treatment modality for cancer
journal, September 2008
- Davis, Mark E.; Chen, Zhuo; Shin, Dong M.
- Nature Reviews Drug Discovery, Vol. 7, Issue 9
Shape effects of filaments versus spherical particles in flow and drug delivery
journal, March 2007
- Geng, Yan; Dalhaimer, Paul; Cai, Shenshen
- Nature Nanotechnology, Vol. 2, Issue 4
Micelles of Different Morphologies—Advantages of Worm-like Filomicelles of PEO-PCL in Paclitaxel Delivery
journal, June 2007
- Cai, Shenshen; Vijayan, Kandaswamy; Cheng, Debbie
- Pharmaceutical Research, Vol. 24, Issue 11
Flexible Filaments for in Vivo Imaging and Delivery: Persistent Circulation of Filomicelles Opens the Dosage Window for Sustained Tumor Shrinkage
journal, March 2009
- Christian, David A.; Cai, Shenshen; Garbuzenko, Olga B.
- Molecular Pharmaceutics, Vol. 6, Issue 5
The effect of particle design on cellular internalization pathways
journal, August 2008
- Gratton, S. E. A.; Ropp, P. A.; Pohlhaus, P. D.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 33, p. 11613-11618
Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment
journal, October 2011
- Wojtkowiak, Jonathan W.; Verduzco, Daniel; Schramm, Karla J.
- Molecular Pharmaceutics, Vol. 8, Issue 6
Design, Synthesis, and Characterization of pH-Sensitive PEG−PE Conjugates for Stimuli-Sensitive Pharmaceutical Nanocarriers: The Effect of Substitutes at the Hydrazone Linkage on the pH Stability of PEG−PE Conjugates
journal, March 2007
- Kale, Amit A.; Torchilin, Vladimir P.
- Bioconjugate Chemistry, Vol. 18, Issue 2
The pH-dependent association with cancer cells of tunable functionalized lipid vesicles with encapsulated doxorubicin for high cell-kill selectivity
journal, May 2010
- Karve, Shrirang; Bandekar, Amey; Ali, Md. R.
- Biomaterials, Vol. 31, Issue 15
Polymeric anticancer drugs with pH-controlled activation
journal, June 2004
- Ulbrich, K.; Etrych, T.; Chytil, P.
- International Journal of Pharmaceutics, Vol. 277, Issue 1-2
N-Boc-Histidine-Capped PLGA-PEG-PLGA as a Smart Polymer for Drug Delivery Sensitive to Tumor Extracellular pH
journal, June 2010
- Chang, Guangtao; Li, Chong; Lu, Weiyue
- Macromolecular Bioscience, Vol. 10, Issue 10
In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles
journal, January 2010
- Koo, Heebeom; Lee, Hyejung; Lee, Sojin
- Chemical Communications, Vol. 46, Issue 31
Doxorubicin loaded pH-sensitive micelle targeting acidic extracellular pH of human ovarian A2780 tumor in mice
journal, August 2005
- Gao, Z. G.; Lee, D. H.; Kim, D. I.
- Journal of Drug Targeting, Vol. 13, Issue 7
Physicochemical characteristics of pH-sensitive poly(l-Histidine)-b-poly(ethylene glycol)/poly(l-Lactide)-b-poly(ethylene glycol) mixed micelles
journal, March 2008
- Yin, Haiqing; Lee, Eun Seong; Kim, Dongin
- Journal of Controlled Release, Vol. 126, Issue 2
Tumor pH-responsive flower-like micelles of poly(l-lactic acid)-b-poly(ethylene glycol)-b-poly(l-histidine)
journal, October 2007
- Lee, Eun Seong; Oh, Kyung Taek; Kim, Dongin
- Journal of Controlled Release, Vol. 123, Issue 1
Functional Supramolecular Polymers
journal, February 2012
- Aida, T.; Meijer, E. W.; Stupp, S. I.
- Science, Vol. 335, Issue 6070
Self-assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials
journal, January 2010
- Cui, Honggang; Webber, Matthew J.; Stupp, Samuel I.
- Biopolymers, Vol. 94, Issue 1, p. 1-18
Nanostructure-templated control of drug release from peptide amphiphile nanofiber gels
journal, January 2012
- Matson, John B.; Newcomb, Christina J.; Bitton, Ronit
- Soft Matter, Vol. 8, Issue 13
Fine-Tuning the pH Trigger of Self-Assembly
journal, February 2012
- Ghosh, Arijit; Haverick, Mark; Stump, Keith
- Journal of the American Chemical Society, Vol. 134, Issue 8
Structural properties of soluble peptide amphiphile micelles
journal, January 2011
- Trent, Amanda; Marullo, Rachel; Lin, Brian
- Soft Matter, Vol. 7, Issue 20
Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles
journal, January 2006
- Kokkoli, Efrosini; Mardilovich, Anastasia; Wedekind, Alison
- Soft Matter, Vol. 2, Issue 12
Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials
journal, April 2002
- Hartgerink, J. D.; Beniash, E.; Stupp, S. I.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 8, p. 5133-5138
Molecular Simulation Study of Peptide Amphiphile Self-Assembly
journal, February 2008
- Velichko, Yuri S.; Stupp, Samuel I.; de la Cruz, Monica Olvera
- The Journal of Physical Chemistry B, Vol. 112, Issue 8
pH-responsive branched peptide amphiphile hydrogel designed for applications in regenerative medicine with potential as injectable tissue scaffolds
journal, January 2012
- Lin, Brian F.; Megley, Katie A.; Viswanathan, Nickesh
- Journal of Materials Chemistry, Vol. 22, Issue 37
Induction of Cancer Cell Death by Self-assembling Nanostructures Incorporating a Cytotoxic Peptide
journal, March 2010
- Standley, Stephany M.; Toft, Daniel J.; Cheng, Hao
- Cancer Research, Vol. 70, Issue 8
Antitumor Activity of Peptide Amphiphile Nanofiber-Encapsulated Camptothecin
journal, October 2011
- Soukasene, Stephen; Toft, Daniel J.; Moyer, Tyson J.
- ACS Nano, Vol. 5, Issue 11
Switching of self-assembly in a peptide nanostructure with a specific enzyme
journal, January 2011
- Webber, Matthew J.; Newcomb, Christina J.; Bitton, Ronit
- Soft Matter, Vol. 7, Issue 20
Responsive Vesicles from Dynamic Covalent Surfactants
journal, March 2011
- Minkenberg, Christophe B.; Li, Feng; van Rijn, Patrick
- Angewandte Chemie, Vol. 123, Issue 15
Light-induced self-assembly of nanofibers inside liposomes
journal, January 2008
- Lee, Hyung-Kun; Soukasene, Stephen; Jiang, Hongzhou
- Soft Matter, Vol. 4, Issue 5
Light-Triggered Bioactivity in Three Dimensions
journal, July 2009
- Muraoka, Takahiro; Koh, Chung-Yan; Cui, Honggang
- Angewandte Chemie, Vol. 121, Issue 32
Prediction of “Aggregation-prone” and “Aggregation-susceptible” Regions in Proteins Associated with Neurodegenerative Diseases
journal, July 2005
- Pawar, Amol P.; DuBay, Kateri F.; Zurdo, Jesús
- Journal of Molecular Biology, Vol. 350, Issue 2
Self-Assembly of Peptide−Amphiphile Nanofibers: The Roles of Hydrogen Bonding and Amphiphilic Packing
journal, June 2006
- Paramonov, Sergey E.; Jun, Ho-Wook; Hartgerink, Jeffrey D.
- Journal of the American Chemical Society, Vol. 128, Issue 22
Tuning Supramolecular Rigidity of Peptide Fibers through Molecular Structure
journal, May 2010
- Pashuck, E. Thomas; Cui, Honggang; Stupp, Samuel I.
- Journal of the American Chemical Society, Vol. 132, Issue 17
Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis -Diols
journal, January 2012
- Li, Yuanpei; Xiao, Wenwu; Xiao, Kai
- Angewandte Chemie, Vol. 124, Issue 12
Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours
journal, October 2013
- Yim, Hyeona; Park, Sin-jung; Bae, You Han
- Biomaterials, Vol. 34, Issue 31
Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model
journal, August 2012
- Stylianopoulos, Triantafyllos; Soteriou, Konstantinos; Fukumura, Dai
- Annals of Biomedical Engineering, Vol. 41, Issue 1
Self-assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials
journal, January 2010
- Cui, Honggang; Webber, Matthew J.; Stupp, Samuel I.
- Biopolymers, Vol. 94, Issue 1, p. 1-18
N-Boc-Histidine-Capped PLGA-PEG-PLGA as a Smart Polymer for Drug Delivery Sensitive to Tumor Extracellular pH
journal, June 2010
- Chang, Guangtao; Li, Chong; Lu, Weiyue
- Macromolecular Bioscience, Vol. 10, Issue 10
Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model
journal, August 2012
- Stylianopoulos, Triantafyllos; Soteriou, Konstantinos; Fukumura, Dai
- Annals of Biomedical Engineering, Vol. 41, Issue 1
The pH-dependent association with cancer cells of tunable functionalized lipid vesicles with encapsulated doxorubicin for high cell-kill selectivity
journal, May 2010
- Karve, Shrirang; Bandekar, Amey; Ali, Md. R.
- Biomaterials, Vol. 31, Issue 15
Prediction of “Aggregation-prone” and “Aggregation-susceptible” Regions in Proteins Associated with Neurodegenerative Diseases
journal, July 2005
- Pawar, Amol P.; DuBay, Kateri F.; Zurdo, Jesús
- Journal of Molecular Biology, Vol. 350, Issue 2
Self-Assembly of Peptide−Amphiphile Nanofibers: The Roles of Hydrogen Bonding and Amphiphilic Packing
journal, June 2006
- Paramonov, Sergey E.; Jun, Ho-Wook; Hartgerink, Jeffrey D.
- Journal of the American Chemical Society, Vol. 128, Issue 22
Fine-Tuning the pH Trigger of Self-Assembly
journal, February 2012
- Ghosh, Arijit; Haverick, Mark; Stump, Keith
- Journal of the American Chemical Society, Vol. 134, Issue 8
Tuning Supramolecular Rigidity of Peptide Fibers through Molecular Structure
journal, May 2010
- Pashuck, E. Thomas; Cui, Honggang; Stupp, Samuel I.
- Journal of the American Chemical Society, Vol. 132, Issue 17
Molecular Simulation Study of Peptide Amphiphile Self-Assembly
journal, February 2008
- Velichko, Yuri S.; Stupp, Samuel I.; de la Cruz, Monica Olvera
- The Journal of Physical Chemistry B, Vol. 112, Issue 8
Antitumor Activity of Peptide Amphiphile Nanofiber-Encapsulated Camptothecin
journal, October 2011
- Soukasene, Stephen; Toft, Daniel J.; Moyer, Tyson J.
- ACS Nano, Vol. 5, Issue 11
Nanocarriers as an emerging platform for cancer therapy
journal, December 2007
- Peer, Dan; Karp, Jeffrey M.; Hong, Seungpyo
- Nature Nanotechnology, Vol. 2, Issue 12
Shape effects of filaments versus spherical particles in flow and drug delivery
journal, March 2007
- Geng, Yan; Dalhaimer, Paul; Cai, Shenshen
- Nature Nanotechnology, Vol. 2, Issue 4
Light-induced self-assembly of nanofibers inside liposomes
journal, January 2008
- Lee, Hyung-Kun; Soukasene, Stephen; Jiang, Hongzhou
- Soft Matter, Vol. 4, Issue 5
Nanostructure-templated control of drug release from peptide amphiphile nanofiber gels
journal, January 2012
- Matson, John B.; Newcomb, Christina J.; Bitton, Ronit
- Soft Matter, Vol. 8, Issue 13
The effect of particle design on cellular internalization pathways
journal, August 2008
- Gratton, S. E. A.; Ropp, P. A.; Pohlhaus, P. D.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 33, p. 11613-11618
Functional Supramolecular Polymers
journal, February 2012
- Aida, T.; Meijer, E. W.; Stupp, S. I.
- Science, Vol. 335, Issue 6070
Works referencing / citing this record:
Sequence isomerism-dependent self-assembly of glycopeptide mimetics with switchable antibiofilm properties
journal, January 2019
- Chen, Limin; Feng, Jie; Yang, Dan
- Chemical Science, Vol. 10, Issue 35
A review on virus protein self-assembly
journal, November 2019
- Chaudhary, Abha; Yadav, Ram Dhan
- Journal of Nanoparticle Research, Vol. 21, Issue 11
A minimal length rigid helical peptide motif allows rational design of modular surfactants
journal, January 2017
- Mondal, Sudipta; Varenik, Maxim; Bloch, Daniel Nir
- Nature Communications, Vol. 8, Issue 1
Host Materials Transformable in Tumor Microenvironment for Homing Theranostics
journal, February 2017
- Yang, Pei-Pei; Luo, Qiang; Qi, Guo-Bin
- Advanced Materials, Vol. 29, Issue 15
Controlling the Self-Assembly of Biomolecules into Functional Nanomaterials through Internal Interactions and External Stimulations: A Review
journal, February 2019
- Wang, Li; Gong, Coucong; Yuan, Xinzhu
- Nanomaterials, Vol. 9, Issue 2
Impact of charge switching stimuli on supramolecular perylene monoimide assemblies
journal, January 2019
- Dannenhoffer, Adam; Sai, Hiroaki; Huang, Dongxu
- Chemical Science, Vol. 10, Issue 22
Self-assembly of mitochondria-specific peptide amphiphiles amplifying lung cancer cell death through targeting the VDAC1–hexokinase-II complex
journal, January 2019
- Liu, Dan; Angelova, Angelina; Liu, Jianwen
- Journal of Materials Chemistry B, Vol. 7, Issue 30
Dual-Controlled Macroscopic Motions in a Supramolecular Hierarchical Assembly of Motor Amphiphiles
journal, June 2019
- Leung, Franco King-Chi; Kajitani, Takashi; Stuart, Marc C. A.
- Angewandte Chemie International Edition, Vol. 58, Issue 32
Recent progress in supramolecular peptide assemblies as virus mimics for cancer immunotherapy
journal, January 2020
- Cai, Ying; Ran, Wei; Zhai, Yihui
- Biomaterials Science, Vol. 8, Issue 4
Self-Assembled Fluorescent Organic Nanomaterials for Biomedical Imaging
journal, August 2018
- Zhang, Kuo; Gao, Yu-Juan; Yang, Pei-Pei
- Advanced Healthcare Materials, Vol. 7, Issue 20
Peptide self-assembly: thermodynamics and kinetics
journal, January 2016
- Wang, Juan; Liu, Kai; Xing, Ruirui
- Chemical Society Reviews, Vol. 45, Issue 20
Surface-assisted assembly of a histidine-rich lipidated peptide for simultaneous exfoliation of graphite and functionalization of graphene nanosheets
journal, January 2019
- Zhang, Lei; Sheng, Yuebiao; Zehtab Yazdi, Alireza
- Nanoscale, Vol. 11, Issue 6
Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy
journal, February 2018
- Qi, Guo-Bin; Gao, Yu-Juan; Wang, Lei
- Advanced Materials, Vol. 30, Issue 22
pH-triggered morphological change in a self-assembling amphiphilic peptide used as an antitumor drug carrier
journal, January 2020
- Gong, Zhongying; Liu, Xiaoying; Wu, Jingliang
- Nanotechnology, Vol. 31, Issue 16
Functional Control of Peptide Amphiphile Assemblies via Modulation of Internal Cohesion and Surface Chemistry Switch
journal, August 2018
- Lu, Sheng; Cui, Weijia; Li, Jason
- Chemistry - A European Journal, Vol. 24, Issue 52
A photo-degradable injectable self-healing hydrogel based on star poly(ethylene glycol)- b -polypeptide as a potential pharmaceuticals delivery carrier
journal, January 2018
- Zhao, Dinglei; Tang, Quan; Zhou, Qiang
- Soft Matter, Vol. 14, Issue 36
Luminescent platinum( ii ) complexes with self-assembly and anti-cancer properties: hydrogel, pH dependent emission color and sustained-release properties under physiological conditions
journal, January 2015
- Tsai, Johnson Lui-Lui; Zou, Taotao; Liu, Jia
- Chemical Science, Vol. 6, Issue 7
Therapeutic Peptide Amphiphile as a Drug Carrier with ATP-Triggered Release for Synergistic Effect, Improved Therapeutic Index, and Penetration of 3D Cancer Cell Spheroids
journal, September 2018
- Lu, Sheng; Zhao, Feng; Zhang, Qiuxin
- International Journal of Molecular Sciences, Vol. 19, Issue 9
Controlling supramolecular polymerization through multicomponent self-assembly
journal, October 2016
- Besenius, Pol
- Journal of Polymer Science Part A: Polymer Chemistry, Vol. 55, Issue 1
The influence of substituents on gelation and stacking order of oligoaramid – based supramolecular networks
journal, January 2019
- Drechsler, Susanne; Balog, Sandor; Kilbinger, Andreas F. M.
- Soft Matter, Vol. 15, Issue 36
Dual‐Controlled Macroscopic Motions in a Supramolecular Hierarchical Assembly of Motor Amphiphiles
journal, June 2019
- Leung, Franco King‐Chi; Kajitani, Takashi; Stuart, Marc C. A.
- Angewandte Chemie, Vol. 131, Issue 32
Ibuprofen loading and release in amphiphilic peptide FA32 and its derivatives: a coarse-grained molecular dynamics simulation study
text, January 2016
- Thota, Naresh; Hu, Zhongqiao; Jiang, Jianwen
- Taylor & Francis
Synthesis and Self‐assembly of a Helical Polymer Grafted from a Foldable Polyurethane Scaffold
journal, October 2019
- Barman, Ranajit; Dey, Pradip; Mondal, Tathagata
- Chemistry – An Asian Journal, Vol. 14, Issue 24
Secondary Structure-Driven Hydrogelation Using Foldable Telechelic Polymer-Peptide Conjugates
journal, July 2018
- Otter, Ronja; Henke, Nina Alexandra; Berac, Christian
- Macromolecular Rapid Communications, Vol. 39, Issue 17
Supramolecular Nanofibers of Curcumin for Highly Amplified Radiosensitization of Colorectal Cancers to Ionizing Radiation
journal, January 2018
- Xu, Huae; Wang, Tingting; Yang, Chengbiao
- Advanced Functional Materials, Vol. 28, Issue 14
Peptide supramolecular materials for therapeutics
journal, January 2018
- Sato, Kohei; Hendricks, Mark P.; Palmer, Liam C.
- Chemical Society Reviews, Vol. 47, Issue 20
Ibuprofen loading and release in amphiphilic peptide FA32 and its derivatives: a coarse-grained molecular dynamics simulation study
journal, August 2015
- Thota, Naresh; Hu, Zhongqiao; Jiang, Jianwen
- Molecular Simulation, Vol. 42, Issue 8
Ibuprofen loading and release in amphiphilic peptide FA32 and its derivatives: a coarse-grained molecular dynamics simulation study
text, January 2015
- Thota, Naresh; Hu, Zhongqiao; Jiang, Jianwen
- Taylor & Francis
Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation
journal, August 2015
- Ji, Tianjiao; Zhao, Ying; Ding, Yanping
- Angewandte Chemie International Edition, Vol. 55, Issue 3
Therapeutic Peptide Amphiphile as a Drug Carrier with ATP-Triggered Release for Synergistic Effect, Improved Therapeutic Index, and Penetration of 3D Cancer Cell Spheroids
journal, September 2018
- Lu, Sheng; Zhao, Feng; Zhang, Qiuxin
- International Journal of Molecular Sciences, Vol. 19, Issue 9
Controlling the Self-Assembly of Biomolecules into Functional Nanomaterials through Internal Interactions and External Stimulations: A Review
journal, February 2019
- Wang, Li; Gong, Coucong; Yuan, Xinzhu
- Nanomaterials, Vol. 9, Issue 2
MMP-2-Controlled Transforming Micelles for Heterogeneic Targeting and Programmable Cancer Therapy
journal, January 2019
- Wang, Zihua; Wang, Yuehua; Jia, Xiangqian
- Theranostics, Vol. 9, Issue 6