Amphiphiles for protein solubilization and stabilization

Gellman, Samuel Helmer; Chae, Pil Seok; Laible, Phillip D; Wander, Marc J

Title: Amphiphiles for protein solubilization and stabilization

Patent · Tue Nov 04 00:00:00 EST 2014

OSTI ID:1163212

Gellman, Samuel Helmer; Chae, Pil Seok; Laible, Phillip D; Wander, Marc J

The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.

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Research Organization:: Wisconsin Aumni Research Foundation, Madison, WI (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-31-109-ENG38

Assignee:: Wisconsin Aumni Research Foundation (Madison, WI)

Patent Number(s):: 8,877,906

Application Number:: 13/608,385

OSTI ID:: 1163212

Resource Relation:: Patent File Date: 2012 Sep 10

Country of Publication:: United States

Language:: English

References (6)

Amphiphilic agents for membrane protein solubilization McQuade, D. Tyler; Gellman, Samuel H. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6172262 US Patent Document 6,172,262	patent	January 2001
Synthetic Amphiphiles for Membrane Protein Manipulation Gellman, Samuel Helmer; Chae, Pil Seok; Kobilka, Brian https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100311956 US Patent Application 12/731000; 20100311956	patent-application	December 2010
A Straightforward Synthesis of 1-Adamantylmethyl Glycosides, and Their Binding to Cyclodextrins Charbonnier, Florence; Penadés, Soledad European Journal of Organic Chemistry, Vol. 2004, Issue 17 https://doi.org/10.1002/ejoc.200400141	journal	September 2004
Synthesis of some aglycon analogs of globotriosylceramide Hansen, Henrik C.; Magnusson, Göran Carbohydrate Research, Vol. 322, Issue 3-4, p. 181-189 https://doi.org/10.1016/S0008-6215(99)00230-X	journal	December 1999
Synthesis and mesogenic properties of a Y-shaped glyco-glycero-lipid Milkereit, G.; Garamus, V. M.; Veermans, K. Chemistry and Physics of Lipids, Vol. 131, Issue 1, p. 51-61 https://doi.org/10.1016/j.chemphyslip.2004.03.011	journal	August 2004
Glycotripod Amphiphiles for Solubilization and Stabilization of a Membrane‐Protein Superassembly: Importance of Branching in the Hydrophilic Portion Chae, Pil S.; Wander, Marc J.; Bowling, Aaron P. ChemBioChem, Vol. 9, Issue 11, p. 1706-1709 https://doi.org/10.1002/cbic.200800169	journal	July 2008

Cited By (1)

Amphiphiles for protein solubilization and stabilization Gellman, Samuel H.; Chae, Pil Seok; Laible, Phillip D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8877906 US Patent Document 8,877,906	patent	November 2014

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