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Title: Systems and methods for laser assisted sample transfer to solution for chemical analysis

Patent ·
OSTI ID:1134059
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Systems and methods are described for laser ablation of an analyte from a specimen and capturing of the analyte in a dispensed solvent to form a testing solution. A solvent dispensing and extraction system can form a liquid microjunction with the specimen. The solvent dispensing and extraction system can include a surface sampling probe. The laser beam can be directed through the surface sampling probe. The surface sampling probe can also serve as an atomic force microscopy probe. The surface sampling probe can form a seal with the specimen. The testing solution including the analyte can then be analyzed using an analytical instrument or undergo further processing.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-000822725
Assignee:
UT-Battelle, LLC (Oak Ridge, TN); University of Tennessee Research Foundation (Knoxville, TN)
Patent Number(s):
8,742,338
Application Number:
13/949,777
OSTI ID:
1134059
Resource Relation:
Patent File Date: 2013 Jul 24
Country of Publication:
United States
Language:
English

References (10)

Miniaturized fluid transfer device patent November 2002
Sampling probe for microarray read out using electrospray mass spectrometry patent October 2004
Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry patent November 2011
Sampling probe for microarray read out using electrospray mass spectrometry patent-application October 2003
Scanning probe microscopy probe and method for scanning probe contact printing patent-application November 2004
Mass Spectrometry With Laser Ablation patent-application June 2008
Solid-Phase Extraction (SPE) Tips and Methods of Use patent-application June 2011
Spatially resolved thermal desorption/ionization coupled with mass spectrometry patent-application March 2012
Surface Sampling Concentration and Reaction Probe patent-application April 2012
Nanodispenser for attoliter volume deposition using atomic force microscopy probes modified by focused-ion-beam milling journal December 2004

Cited By (2)

System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis patent July 2016
Systems and methods for laser assisted sample transfer to solution for chemical analysis patent September 2015

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