Dielectrokinetic chromatography and devices thereof

Chirica, Gabriela S; Fiechtner, Gregory J; Singh, Anup K

Title: Dielectrokinetic chromatography and devices thereof

Patent · Tue Apr 22 00:00:00 EDT 2014

OSTI ID:1129393

Chirica, Gabriela S; Fiechtner, Gregory J; Singh, Anup K

Disclosed herein are methods and devices for dielectrokinetic chromatography. As disclosed, the devices comprise microchannels having at least one perturber which produces a non-uniformity in a field spanning the width of the microchannel. The interaction of the field non-uniformity with a perturber produces a secondary flow which competes with a primary flow. By decreasing the size of the perturber the secondary flow becomes significant for particles/analytes in the nanometer-size range. Depending on the nature of a particle/analyte present in the fluid and its interaction with the primary flow and the secondary flow, the analyte may be retained or redirected. The composition of the primary flow can be varied to affect the magnitude of primary and/or secondary flows on the particles/analytes and thereby separate and concentrate it from other particles/analytes.

View Patent

Cite

Export

Save

Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Number(s):: 8,702,946

Application Number:: 12/128,913

OSTI ID:: 1129393

Resource Relation:: Patent File Date: 2008 May 29

Country of Publication:: United States

Language:: English

References (34)

Apparatus for continuous electrochromatographic separation Karlson, Eskil L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4315812 US Patent Document 4,315,812	patent	February 1982
Polyether-polycarbonates for dialysis membranes Schreckenberg, Manfred; Dhein, Rolf; Lange, Ralf https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4563516 US Patent Document 4,563,516	patent	January 1986
Microlithographic array for macromolecule and cell fractionation Austin, Robert H.; Volkmuth, Wayne; Rathburn, Lynn C. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5427663 US Patent Document 5,427,663	patent	June 1995
Electrokinetic concentration of charged molecules Singh, Anup K.; Neyer, David W.; Schoeniger, Joseph S. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6428666 US Patent Document 6,428,666	patent	August 2002
Device and method for the manipulation of a fluid sample Christel, Lee A.; Kovacs, Gregory T. A.; McMillan, William A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20020175079 US Patent Application 10/118810; 20020175079	patent-application	November 2002
Continuous flow dielectrophoretic particle concentrator Cummings, Eric B. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030010637 US Patent Application 10/176322; 20030010637	patent-application	January 2003
Acute treatment of headache with phenothiazine antipsychotics Hale, Ron L.; Llyod, Peter M.; Lu, Amy T. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040101481 US Patent Application 10/719763; 20040101481	patent-application	May 2004
Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields Huang, Lotien Richard; Sturm, James Christopher https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040144651 US Patent Application 10/693091; 20040144651	patent-application	July 2004
Frit material and bonding method for microfluidic separation devices Koeher, Jeffrey A.; Patel, Paren P. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050006293 US Patent Application 10/916565; 20050006293	patent-application	January 2005
Microfluidic devices comprising biochannels Blackburn, Gary https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050009101 US Patent Application 10/886408; 20050009101	patent-application	January 2005
Microliter scale solid phase extraction devices Chirica, Gabriela S.; Renzi, Ronald F.; Simmons, Blake A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060163143 US Patent Application 11/044788; 20060163143	patent-application	July 2006
Cell separation method using hydrophobic solid supports Lim, Hee-Kyum; Hwang, Kyu-youn; Kim, Joon-ho https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060234379 US Patent Application 11/405106; 20060234379	patent-application	October 2006
Coherent nonlinear chromatography and methods and devices thereof Cummings, Eric B. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070084727 US Patent Application 11/249383; 20070084727	patent-application	April 2007
Coupling for conduits sealed in a recess of a housing Mueller, Jochen; Kraiczek, Karsten; Beigel, Bertram https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070132230 US Patent Application 11/302873; 20070132230	patent-application	June 2007
Planar quartz chips with submicron channels for two-dimensional capillary electrophoresis applications Becker, H.; Lowack, K.; Manz, A. Journal of Micromechanics and Microengineering, Vol. 8, Issue 1 https://doi.org/10.1088/0960-1317/8/1/004	journal	March 1998
Planar dielectrochromatography on non-wetted thin layers Kreibik, Stefan; Coman, Virginia; Măruțoiu, Constantin Journal of Planar Chromatography – Modern TLC, Vol. 14, Issue 4 https://doi.org/10.1556/JPC.14.2001.4.4	journal	August 2001
Dielectrophoretic chromatography with cross-flow injection Sano, H.; Kabata, H.; Kurosawa, O. Technical Digest. MEMS 2002 IEEE International Conference. Fifteenth IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.02CH37266) https://doi.org/10.1109/MEMSYS.2002.984043	conference	January 2002
CdSe nanowires with illumination-enhanced conductivity: Induced dipoles, dielectrophoretic assembly, and field-sensitive emission Zhou, Ronghui; Chang, Hsueh-Chia; Protasenko, Vladimir Journal of Applied Physics, Vol. 101, Issue 7 https://doi.org/10.1063/1.2714670	journal	April 2007
High-intensity, high-gradient electric separation and dielectric filtration of particulate and granular materials Lin, I. J.; Benguigui, L. Journal of Electrostatics, Vol. 13, Issue 3, p. 257-278 https://doi.org/10.1016/0304-3886(82)90046-8	journal	December 1982
Fabrication of microstructures with high aspect ratios and great structural heights by synchrotron radiation lithography, galvanoforming, and plastic moulding (LIGA process) Becker, E. W.; Ehrfeld, W.; Hagmann, P. Microelectronic Engineering, Vol. 4, Issue 1, p. 35-56 https://doi.org/10.1016/0167-9317(86)90004-3	journal	May 1986
Sorting by diffusion: An asymmetric obstacle course for continuous molecular separation Chou, C. -F.; Bakajin, O.; Turner, S. W. P. Proceedings of the National Academy of Sciences, Vol. 96, Issue 24 https://doi.org/10.1073/pnas.96.24.13762	journal	November 1999
Separating Microbes in the Manner of Molecules. 1. Capillary Electrokinetic Approaches Armstrong, Daniel W.; Schulte, Georg; Schneiderheinze, Jeffrey M. Analytical Chemistry, Vol. 71, Issue 24 https://doi.org/10.1021/ac990779z	journal	December 1999
Silicate entrapped columns — new columns designed for capillary electrochromatography Chirica, Gabriela; Remcho, Vincent T. Electrophoresis, Vol. 20, Issue 1, p. 50-56 https://doi.org/10.1002/(SICI)1522-2683(19990101)20:1<50::AID-ELPS50>3.0.CO;2-O	journal	January 1999
Separation of Long DNA Molecules in a Microfabricated Entropic Trap Array Han, J. Science, Vol. 288, Issue 5468 https://doi.org/10.1126/science.288.5468.1026	journal	May 2000
Determination of Cell Viability in Single or Mixed Samples Using Capillary Electrophoresis Laser-Induced Fluorescence Microfluidic Systems Armstrong, Daniel W.; He, Lingfeng Analytical Chemistry, Vol. 73, Issue 19 https://doi.org/10.1021/ac010449q	journal	October 2001
Electrochromatography in Microchips: Reversed-Phase Separation of Peptides and Amino Acids Using Photopatterned Rigid Polymer Monoliths Throckmorton, Daniel J.; Shepodd, Timothy J.; Singh, Anup K. Analytical Chemistry, Vol. 74, Issue 4 https://doi.org/10.1021/ac011077o	journal	February 2002
A DNA prism for high-speed continuous fractionation of large DNA molecules Huang, Lotien Richard; Tegenfeldt, Jonas O.; Kraeft, Jessica J. Nature Biotechnology, Vol. 20, Issue 10 https://doi.org/10.1038/nbt733	journal	September 2002
Dielectrophoretic filter for separation and recovery of biological cells in water Suehiro, J.; Imamura, M. IEEE Transactions on Industry Applications, Vol. 39, Issue 5 https://doi.org/10.1109/TIA.2003.816535	journal	September 2003
Electroporation of Mammalian Cells in a Microfluidic Channel with Geometric Variation Wang, Hsiang-Yu; Lu, Chang Analytical Chemistry, Vol. 78, Issue 14 https://doi.org/10.1021/ac060733n	journal	July 2006
Dielectrophoresis in Microchips Containing Arrays of Insulating Posts: Theoretical and Experimental Results Cummings, Eric B.; Singh, Anup K. Analytical Chemistry, Vol. 75, Issue 18 https://doi.org/10.1021/ac0340612	journal	September 2003
Insulator-based dielectrophoresis for the selective concentration and separation of live bacteria in water Lapizco-Encinas, Blanca H.; Simmons, Blake A.; Cummings, Eric B. ELECTROPHORESIS, Vol. 25, Issue 1011 https://doi.org/10.1002/elps.200405899	journal	June 2004
Dielectrophoretic Concentration and Separation of Live and Dead Bacteria in an Array of Insulators Lapizco-Encinas, Blanca H.; Simmons, Blake A.; Cummings, Eric B. Analytical Chemistry, Vol. 76, Issue 6 https://doi.org/10.1021/ac034804j	journal	March 2004
Streaming dielectrophoresis for continuous-flow microfluidic devices Cummings, E. B. IEEE Engineering in Medicine and Biology Magazine, Vol. 22, Issue 6 https://doi.org/10.1109/MEMB.2003.1266050	journal	November 2003
Microfluidic Cell Separation by 2-dimensional Dielectrophoresis Gasperis, Giovanni De; Yang, Jun; Becker,, Frederick F. Biomedical Microdevices, Vol. 2, Issue 1, p. 41-49 https://doi.org/10.1023/A:1009955200029	journal	January 1999

Cited By (1)

Dielectrokinetic chromatography devices Chirica, Gabriela S.; Fiechtner, Gregory J.; Singh, Anup K. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8911606 US Patent Document 8,911,606	patent	December 2014

Similar Records

Dielectrokinetic chromatography devices

Patent · Tue Dec 16 00:00:00 EST 2014 · OSTI ID:1129393

Chirica, Gabriela S; Fiechtner, Gregory J; Singh, Anup K

The inductively driven transmission line: A passively coupled device for diagnostic applications on the Z pulsed power facility

Journal Article · Mon Mar 01 00:00:00 EST 2021 · Review of Scientific Instruments · OSTI ID:1129393

Myers, Clayton E.; Lamppa, Derek C.; Jennings, Christopher A.; +6 more

Surface-Micromachined Microfluidic Devices

Patent · Tue Sep 28 00:00:00 EDT 2004 · OSTI ID:1129393

Galambos, Paul C; Okandan, Murat; Montague, Stephen; +5 more

Related Subjects

47 OTHER INSTRUMENTATION

Title: Dielectrokinetic chromatography and devices thereof

Citation Formats

References (34)

Cited By (1)

Similar Records

Related Subjects