DE-SC0002437 Final Report
- Vanderbilt University
We developed a SPECT/CT system for small-animal imaging utilizing a mechanically cooled, position-sensitive germanium detector for the SPECT camera. The detector offers better energy resolution than any other detector previously used for SPECT and demonstrates dual-isotope imaging capabilities superior to that of current commercial small-animal SPECT systems. We also explored a unique SPECT camera configuration consisting of a silicon detector and germanium detector stacked one behind the other and located behind a multi-pinhole collimator. This scheme is intended for imaging iodine-123 radiotracer distributions, with the ~30 keV x-ray emissions detected in the silicon detector and the 159 keV gamma-ray emissions passing through the silicon and detected in the germanium detector. Image reconstruction methods for combining this multi-energy, multi-magnification data were developed and it was shown that inclusion of the silicon data reduced artifacts in comparison to the germanium data alone.
- Research Organization:
- Vanderbilt Univ., Nashville, TN (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- Contributing Organization:
- Vanderbilt University
- DOE Contract Number:
- SC0002437
- OSTI ID:
- 1128937
- Report Number(s):
- DOE-VANDERBILT-0002437
- Country of Publication:
- United States
- Language:
- English
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