skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Arterial endothelial function measurement method and apparatus

Patent ·
OSTI ID:1126883
;

A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
8,666,472
Application Number:
11/362,326
OSTI ID:
1126883
Country of Publication:
United States
Language:
English

References (36)

Method of and apparatus for analyzing propagation of arterial pulse waves through the circulatory system patent July 1991
Oscillometric blood pressure monitor which acquires blood pressure signals from composite arterial pulse signal patent October 1997
Method and apparatus for calculating blood pressure of an artery patent August 1998
Apparatus and method for non-invasively monitoring a subject's arterial blood pressure patent December 1998
Calibrated measurement of blood vessels and endothelium after reactive hyperemia and method therefor patent November 2000
Sensor for non-invasive and continuous determination of the duration of arterial pulse waves patent March 2001
Apparatus and method for non-invasively monitoring a subjects arterial blood pressure patent May 2001
Method and apparatus for the non-invasive detection of medical conditions by monitoring peripheral arterial tone patent November 2001
Method and system for detecting vascular conditions using an occlusive arm cuff plethysmograph patent January 2002
Diagnostic apparatus for analyzing arterial pulse waves patent April 2002
Ultrasonic sensors for monitoring the condition of flow through a cardiac valve patent June 2002
Intravascular ultrasound imaging apparatus and method patent July 2003
Method and system for detecting vascular conditions using an occlusive arm cuff plethysmograph patent September 2003
Method of measuring endothelial function in a person patent June 2005
Method for diagnosing, monitoring and treating hypertension and other cardiac problems patent-application August 2001
Effect of Gemfibrozil ± Niacin ± Cholestyramine on Endothelial Function in Patients With Serum Low-Density Lipoprotein Cholesterol Levels <160 mg/dl and High-Density Lipoprotein Cholesterol Levels <40 mg/dl journal October 1997
Dispersion and Attenuation of Small Artificial Pressure Waves in the Canine Aorta journal October 1968
Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction journal November 1994
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis journal November 1992
Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans. journal September 1989
Replacement of Dietary Saturated Fatty Acids by Trans Fatty Acids Lowers Serum HDL Cholesterol and Impairs Endothelial Function in Healthy Men and Women journal July 2001
Reproducibility of brachial ultrasonography and flow-mediated dilatation (FMD) for assessing endothelial function journal December 1997
Regular Aerobic Exercise Augments Endothelium-Dependent Vascular Relaxation in Normotensive As Well As Hypertensive Subjects: Role of Endothelium-Derived Nitric Oxide journal September 1999
A Method Using Induced Waves to Study Pressure Propagation in Human Arteries journal November 1957
The Role of Duplex Scanning in the Selection of Patients with Critical Lower-Limb Ischemia for Infrainguinal Percutaneous Transluminal Angioplasty journal July 2001
Validation of a device to measure arterial pulse wave velocity by a photoplethysmographic method journal July 2002
Instrument for the noninvasive evaluation of human arterial endothelial function via measurement of changes in the transit time of an artificial pulse
  • Maltz, J. S.; Budinger, T. F.
  • Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439) https://doi.org/10.1109/IEMBS.2003.1280806
conference January 2003
Early evidence of endothelial vasodilator dysfunction at coronary branch points. journal October 1990
The pathogenesis of atherosclerosis: a perspective for the 1990s journal April 1993
Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level. journal January 1994
Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. journal September 1995
Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. journal February 1990
Impaired endothelial function following a meal rich in used cooking fat journal March 1999
Duplex ultrasound scanning versus computed tomographic angiography for postoperative evaluation of endovascular abdominal aortic aneurysm repair journal December 2000
Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis. journal February 1990
Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. journal February 1991

Cited By (1)

Arterial endothelial function measurement method and apparatus patent March 2014

Similar Records

Benefits of Synchrotron Microangiography for Dynamic Studies of Smooth Muscle and Endothelial Roles in the Pathophysiology of Vascular Disease
Journal Article · Fri Jul 23 00:00:00 EDT 2010 · AIP Conference Proceedings · OSTI ID:1126883
+8 more
Diesel exhaust particles induce endothelial dysfunction in apoE{sup -/-} mice
Journal Article · Thu Feb 15 00:00:00 EST 2007 · Toxicology and Applied Pharmacology · OSTI ID:1126883
+4 more
Statins attenuate the development of atherosclerosis and endothelial dysfunction induced by exposure to urban particulate matter (PM{sub 10})
Journal Article · Tue Oct 01 00:00:00 EDT 2013 · Toxicology and Applied Pharmacology · OSTI ID:1126883
+4 more

Related Subjects

47 OTHER INSTRUMENTATION